DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab3-GAP and rbg-2

DIOPT Version :9

Sequence 1:	NP_609544.2	Gene:	Rab3-GAP / 34626	FlyBaseID:	FBgn0027505	Length:	1341	Species:	Drosophila melanogaster
Sequence 2:	NP_001021631.1	Gene:	rbg-2 / 172574	WormBaseID:	WBGene00004318	Length:	1307	Species:	Caenorhabditis elegans

Alignment Length:	1308	Identity:	268/1308 - (20%)
Similarity:	481/1308 - (36%)	Gaps:	330/1308 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 VAVGLCSGMVTFYTDSGVKL-FSQCCQEDPVIGVKLQSAPRHSEADSLLYIIYPRCLCFIQGQDI 169
            :|:|...|.|.|:|:.|..| |.:....:||..::.:..    :......:::.:....|....:
Worm   162 IALGTLDGHVYFFTEQGTMLYFDRFSIFEPVNSLQFEVV----KTGQTFIVVFTKGFFMINPISL 222

  Fly   170 LPTLNNCRHNVQRGALERSSYPTADVVPFQKYKFKQEREAVINDAAISTTQRPPTYDYIVQQTIG 234
            ...|...:  |.....|::....::.:..|......:.:..|.....:...:|.|    ::|.|.
Worm   223 KSVLYQAK--VLIAKCEKTVKQISESIELQSELLAPDIKGNIIHVIFTGLHKPST----LEQYIS 281

  Fly   235 LGY---FAKVH-ATPPRSSQVLAAGAEPYLGF--FQAEEGYKTMSLGEVAKDVIGIAYKNLLG-- 291
            ..|   :|||. .:.|..|..:....:.:..|  ...||..|.:.      |||... |:|:.
Worm   282 ASYDSFYAKVEKPSLPLYSTFMVTTEKEFAVFVWHDREEQDKLID------DVIKYG-KSLVPSF 339

  Fly   292 GI---FRRAPEP--LPSPEESPLPVPTKEAPMRIRCRLYDGKRDGLTLSVAPGGRLAVVTDNLDR 351
            ||   |..:.||  :.|...|.:..||:...|..|.        ...:|.:|..:...|||.:.|
Worm   340 GIRKFFGISTEPARIASHMRSAVHAPTRSIIMETRV--------AQNVSRSPDCQYVAVTDRMAR 396

  Fly   352 VMLVDTHQAIILRVWKGYRDAQCAFVPVKEKSVRGIKTHKRKALFLVIYAPRMGCLDIWALQNGP 416
            |:::|.....::.::||||||..::|.|.|..        |.|.||.|:|||...|::|.:....
Worm   397 VLVIDIASRQVVLIFKGYRDASISWVSVTEDD--------RVAQFLTIFAPRRSLLEVWTVLGNV 453

  Fly   417 KVAAFNVSKSGQLMYNNHSPLGSGGSSGSGNSSSQSRKSLAINHC--------LFLDPSDGSLKE 473
            :|.|            .|.|      |...|..:.....:....|        .|:| ..|....
Worm   454 RVCA------------QHVP------SSECNVVTGGENKMLCGRCHVHTDSNSFFID-EKGEFHR 499

  Fly   474 IHIPFHYALSETSSQTSRDIHMLRRLRNQLRTINHGQAKDEALQEIGELASELQTLEVRQQCLEM 538
            |.:|||.||:..|.|...|..:|::|.|   |...|       ::..:..|:|:....|:...:.
Worm   500 IALPFHLALTSRSRQDQHDHLLLKQLEN---TKTGG-------EDWFQTFSDLKMATSRKTTFQN 554

  Fly   539 LLKSKKLQPQVFQSIINAFIKK-PLSESTGSEEFVNQIEN----YKRLTDLYLALSQANQREDNE 598
            .|.:.....:..|.|  |.|:. |.|.|.|  :..|..|.    |.|..            .:.:
Worm   555 ALHNLSTAEEAHQFI--ARIRSIPTSASLG--DLPNSAEKSIGFYARTV------------AETK 603

  Fly   599 PPV-EY--LELSDADLVTINKLVL------------LLDDGTEKDKPAATREVSFKLQAEHKTEE 648
            ||| ||  .:.|:..|.:|.:.:|            :|:|.          ||.       |..|
Worm   604 PPVGEYDDKDTSNYKLDSIVERILECHMQKFGERTDMLNDS----------EVM-------KVGE 651

  Fly   649 FVDYLSIFNIDSPDGISLLPEKSDKFGAVSIDLFSQFFAQ-----------GLCFGQFK--QWIN 700
            ::.|:.:...|                   ||:||:.:::           |..||.|:  ::.:
Worm   652 WLKYVDLSQED-------------------IDVFSEHWSEKQRHCLANLIFGPLFGSFEIDEYYD 697

  Fly   701 QACLPSRDLLKLIIWFWLEK-PFKYNNCDEVVEDMSRIAAMVQTICDLAGEHIHDYAYNAISPWW 764
            ..               ||| |.|..|          |..:.....:....||....:|.|...:
Worm   698 TV---------------LEKIPVKRKN----------IVKLFYMRFEKTTTHIDWRIFNRIVEMF 737

  Fly   765 -----------QEVRELLLESKQFS-GLLVAIVCKTVATNLWRNR-----KEGSCDESSQN---- 808
                       ::|.::.::||... |:::..:|       |..|     .:|:.::..:|
Worm   738 LNLEKSETGILEQVDQMAMDSKDVPLGMILLSIC-------WCARIQIRILKGNDEDEVENDHDL 795

  Fly   809 -EDDERWERISHDEAQWGLLTGKLEDVAVLGAILSKPLICRDPVGPEMSYEPPDCS---LKSIVS 869
             |:||:.:.|.    :|..::.:.|.:..:       ::|...|....|....|.:   :..:|.
Worm   796 EEEDEKNKTID----EWDAISPEAEHLDCI-------IMCLHCVSLAQSLLKDDSNILRISDVVP 849

  Fly   870 SGKGIVTELTAKWLISAQLHPSKVLEISP--PENELDDESKVKIKDEPTKESVDEDAESEEDLEM 932
            .....:.|..|||::|..:....:.::.|  |...|.::.                  :|||  .
Worm   850 RIDSYIRENVAKWIVSTPIDTDTIEKLFPRDPSENLAEKG------------------NEED--R 894

  Fly   933 AKEVYAASKEAHEPILERLALLRAHFPFSLESGVLLSLMSWQYMVQWSKQL-SSLDHLKAALLCL 996
            .|::.....:..|.:::|:..:   .|...|..::::.:.|:.|.||.::. .:..::|.....|
Worm   895 RKQMIIDFPDDKEVVIQRMYQI---IPRVFEHDLVVADVCWEMMSQWFREKDDNFSYIKDCTTLL 956

  Fly   997 NQFRTPDWALKHGICCMLWNATLKFPLQAAAKLIQKVGRLPVDKMCQQDLEMSAGKVPEFL---E 1058
            .| ...|..|:|||..::|:..:....|:...:::|.||.|.||..::::.....|:.|||   |
Worm   957 PQ-SIVDPRLRHGIARLIWDKFIFMVFQSIVNMVEKTGRRPKDKETRKEIGFGEVKLEEFLMECE 1020

  Fly  1059 LSLEFLQHFTASMEHD---KRELHFEQSLSEGALPL----------QF--LALQQ---------- 1098
            ..||.|......|...   |::|..|.:.|..|..|          ||  ||.:|
Worm  1021 KFLEVLMDSVRDMPPPIDFKQDLLVEMASSSFAAHLHQSKTAYRQDQFAILASRQPLVNFHLVLH 1085

  Fly  1099 HHAMPQLLRLQTELCSVLHFVSFFQLRIPKPLTTLFDSMSNKALLADINKELPYVLPAPDLVLQQ 1163
            |..:...||||  |.:.|.|         .||..||....|:|..|.::......|...|....:
Worm  1086 HQHLALALRLQ--LTTGLRF---------HPLRNLFCVTGNRAFFASLDSHPLIPLDRVDDATME 1139

  Fly  1164 QRTEFLCRLVTATMDLIREDLEQLYILDHVFYMGKICALADSWEVDKLPILRRQVVELYAFGYDA 1228
            :|..||.::..      :..:|:..:..|         |...|::....|...|.:..:..|.|.
Worm  1140 KRHAFLVKVAE------QGSMEERRLARH---------LEMEWKLTVNEISFMQALSSFRLGNDH 1189

  Fly  1229 EAQV-LLQDISDDEELGRLLLEIAGRRLNLYAQSSQ------STFLKIASVGHQ---LLAYLDNL 1283
            :..: |...:.||.....|...:|.|.:.|..::::      |.:| .|..|.:   :..|.::.
Worm  1190 QGSLELASCVRDDRSAVALARVLAARLIQLANEANKRYSTAHSQYL-CALAGEEAARVELYENSP 1253

  Fly  1284 KEPMTENN 1291
            .:|:.::|
Worm  1254 DDPLVDSN 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab3-GAP	NP_609544.2	RAB3GAP2_N	29..430	CDD:291327	76/337 (23%)
Rab3-GAP	NP_609544.2	RAB3GAP2_C	710..1319	CDD:291328	129/649 (20%)
rbg-2	NP_001021631.1	RAB3GAP2_N	88..465	CDD:291327	79/353 (22%)
rbg-2	NP_001021631.1	RAB3GAP2_C	786..1202	CDD:291328	97/476 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161033
Domainoid	1	1.000	62	1.000	Domainoid score	I6875
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I3102
Isobase	1	0.950	-	0	Normalized mean entropy	S7906
OMA	1	1.010	-	-		QHG52979
OrthoDB	1	1.010	-	-		D29182at33208
OrthoFinder	1	1.000	-	-		FOG0005758
OrthoInspector	1	1.000	-	-		oto19715
orthoMCL	1	0.900	-	-		OOG6_105335
Panther	1	1.100	-	-	LDO	PTHR12472
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2746
SonicParanoid	1	1.000	-	-		X4151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.980