DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab3-GAP and rab3gap2

DIOPT Version :9

Sequence 1:	NP_609544.2	Gene:	Rab3-GAP / 34626	FlyBaseID:	FBgn0027505	Length:	1341	Species:	Drosophila melanogaster
Sequence 2:	NP_001120595.1	Gene:	rab3gap2 / 100145752	XenbaseID:	XB-GENE-987874	Length:	1408	Species:	Xenopus tropicalis

Alignment Length:	1411	Identity:	391/1411 - (27%)
Similarity:	641/1411 - (45%)	Gaps:	263/1411 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NWLNAINHAISPTGELIAMAQGEKLAFLSTCWSSHGNGN---TYVLGWCGEL--ED------PNQ 81
            :||.....::|||.:|:.:|..:|..||:..|...|.|.   .|.:.|.|.|  ||      .::
Frog    88 HWLQDCVLSLSPTNDLMVIAHEQKAVFLAPKWKGSGKGKEEMQYEVVWSGSLTVEDGFLTIEDSE 152

  Fly    82 IVTSLTCLPM-TQNKSTDGAIEWTCVAVGLCSGMVTFYTDSGVKLFSQCCQEDPVIGVKLQS--A 143
            .::|..|:|: :|.:|:.|..:|||:..|..||.|.|||:|||.|.||...::.|:.:|.::  .
Frog   153 CISSALCIPLASQKRSSTGRPDWTCIVFGFTSGYVRFYTESGVLLLSQLLNQEAVLQLKCRTYEV 217

  Fly   144 PRH---SEADSLLYIIYPRCLCFIQGQDILPTLNNCRHNVQRGALERSSYPTADVVPFQKYKFKQ 205
            |||   :|....:.::||..:..|.|..:..:|..||:.|.|.|...|.......:.::|:.. |
Frog   218 PRHPGVTEQHEEMSLLYPSAVVTIDGFSLFQSLRACRNQVARAAASGSENVQPPPLAYKKWGL-Q 281

  Fly   206 EREAVINDAAISTTQRPPTYDYIVQQTIGLGYFAKVHATPPRSSQVLAAGAEPYLGFFQAEEGYK 270
            :.:.:::.|::......| :|.:...:|..|:.|.:.::||..||.:..|:.|:.|||.|.||..
Frog   282 DVDRIVDHASVGVMALSP-FDQMKTASILGGFNAAIKSSPPTMSQYITVGSNPFTGFFFALEGST 345

  Fly   271 TMSLGEVAKDVIGIAYKNLLGGIFRRAP---------EPLPSPEESPLPVPTKEAPMRIRCRLYD 326
            ...|..||   :.:|.| |...:|..|.         |..|..::.|...|..  |:.:|..|.|
Frog   346 QPLLSHVA---LAVASK-LTSALFSAASGWLGWKSKHEEEPQQKQKPKVEPAN--PLAVRFGLPD 404

  Fly   327 GKRDGLTLSVAPGGRLAVVTDNLDRVMLVDTHQAIILRVWKGYRDAQCAFVPVKE-----KSVRG 386
            .:|.|..:|::|...||.|||:..||:|:|..:.|.:|:||||||||..::.:.|     :|.||
Frog   405 SRRHGERVSLSPCNTLAAVTDDFGRVILLDVGRGIAIRMWKGYRDAQVGWMQIVEDLHERESERG 469

  Fly   387 -------IKTHKRKALFLVIYAPRMGCLDIWALQNGPKVAAFNVSKSGQLMYNNHSPLGSGGSSG 444
                   :|...|.|.||||||||.|.|::|:.|.||:|.||||.|..:|:|..:..:      |
Frog   470 HHSPFQNVKGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIM------G 528

  Fly   445 SGNSSSQSRKSLAINHCLFLDPSDGSLKEIHIPFHYALSETSSQTSRDIHMLRRLRNQL--RTIN 507
            ..|.:||..:......|| :||..|:::.::||||.||.:...:.::|:|::::|...|  :..:
Frog   529 LNNVTSQGWQPQTYQICL-IDPVSGNVRTVNIPFHLALRDKKCERAKDMHLVKKLSMLLKAKVPD 592

  Fly   508 HGQAKDEALQEIGELASELQTLEVRQQCLEMLLKSKKLQPQVFQSIINAFIKKPLSESTGSEEFV 572
            |.:.:.||    .|:..:::....::|.||.:|.|.::.   |.|:.:  |.:.|.:|..::|
Frog   593 HERLETEA----KEIILDIKYPATKKQALERILASDRVP---FSSLTS--ITQTLMDSLKNQE-- 646

  Fly   573 NQIENYKRLTDLYLALSQANQREDNEPPVEYLELSDADLVTI--NKLVLL---------LDDGTE 626
                                           ||..|.||:..  :||.||         ....||
Frog   647 -------------------------------LETVDEDLLAFCRDKLKLLHLYESVKRISSVATE 680

  Fly   627 KDKPAATREVSFKLQAEHKTEEFVDYLSIFNIDSPDGI------------SLLPEKS-------D 672
            .|...:.:|::..|:.:.  .||....|:.. :...||            |:||.|:       |
Frog   681 SDPSPSDKELAQLLRLDE--NEFARVQSLIR-NYKQGIPRAGVHFAEDEGSILPVKTFLEYLECD 742

  Fly   673 KFGAVSIDLFSQ---------FF---------AQGLCFGQFKQWINQACLPSRDLLKLIIWFWLE 719
            : .|:::...|:         ||         ||.:|     |.:..|.|..:.||.|::..||.
Frog   743 R-DAINVKKISEEEHIALGSFFFWKCLHGECSAQEMC-----QTLESAGLNPQLLLSLLLKVWLS 801

  Fly   720 KPFKYNNCDEVVEDMSR----IAAMVQTICDLAGEHIHDYAYNAISPWWQEVRELLLE-SKQFSG 779
            :       :....|..:    :.:|:..:.::.......:...::|||||::|...:: |...:.
Frog   802 R-------ERETADKKQWLRCLHSMLSLLSNMKVAIDESWDLQSVSPWWQQMRTTCVQSSSNGAA 859

  Fly   780 LLVAIVCKTVATNLWRNRKEGSCDESSQNEDDE----RWERISHDEAQWGLLTGKLEDVAVLGAI 840
            ||.|.|..:||.::.....|.....|.|::|.|    .||.:|.|...|.||..:|||..:|..:
Frog   860 LLCAHVGHSVAASITNALAERKFPSSGQDDDVESMTDSWEALSLDTEYWKLLLKQLEDCLILQTL 924

  Fly   841 LSKPLICRDPVGPEMSYEP-PDCSLKSIVSSGKGIVTELTAKWLISAQLHPSKVLEISPPENELD 904
            |....|........:..|| |..|:|:::..|||.|.:..|||:....:.|..:.|.
Frog   925 LHCKAIRPSARVSALQAEPLPRLSVKNLLEGGKGGVADTLAKWVFKQDISPDLLREA-------- 981

  Fly   905 DESKVKIKDEPTK-ESVDEDAESEEDLEMAKEVYAASKEAHEPILERLALLRAHFPFSLESGVLL 968
             :||.:::..|.: .::....||:.::            |.|.|...|.|...|||.||:..||.
Frog   982 -QSKREVEQVPMETNAIVLRTESQAEV------------AAEEIQALLYLAYQHFPSSLDLDVLH 1033

  Fly   969 SLMSWQYMVQWSKQ-------LSSLDHLKAALLCLNQFRTPDWALKHGICCMLWNATLKFPLQAA 1026
            :...|:|::||:|.       ..|:||||         |..:..::.|:..|:||..:.....||
Frog  1034 AHCCWEYVLQWNKDPEEVQFLARSIDHLK---------RISNAHVQFGLSLMMWNTFIIKRFSAA 1089

  Fly  1027 AKLIQKVGRLPVDKMCQQDLEMSAGKVPEFLELSLEFLQHFTASMEHDKRE-------LHFEQSL 1084
            |.||.|||:.|.|::|::|:.||...:..||....:.||   |.||.|...       |..|.|.
Frog  1090 AYLIDKVGKAPKDRLCRRDVGMSDTAMGSFLGSCSDLLQ---AMMEADVSSEEMQAPLLELEDSW 1151

  Fly  1085 --SEGALPLQFLALQQHHAMPQLLRLQTELCSVLHFVSFFQLRIPKPLTTLFDSMSNKALLADIN 1147
              .||...:..|||:|.|....|:..|..|.::|:.|..|.|:..||| .|:||....|...|:.
Frog  1152 VNMEGPSSIVELALEQKHIHYPLVEHQFVLSAILYSVMRFSLKSIKPL-ALYDSKGKNAFFKDLT 1215

  Fly  1148 KELPYVLPA----PDLV-LQQQRTEFLCRLVTATMDLIREDLEQLYILDH---------VFYMGK 1198
            .  ..:||:    |.|| |:||   ||.:::::.:..:.|..|... .:|         |.:...
Frog  1216 S--IQLLPSGDADPSLVSLRQQ---FLLKVISSAIQTLAETQEPTQ-SEHSAAEIPEKSVDWPEL 1274

  Fly  1199 ICALADSWEVDKLPILRRQVVELYAFGYDAEAQVLLQDISDDEELGRLLLEIAGRRLN---LYAQ 1260
            ...||...:|::..|.|..|.|||::|:|..|:..:..:.|.|.|...||.:.|:||.   |:.|
Frog  1275 AVGLARHLQVNEDTIWRHYVCELYSYGFDHLAEEAILRVLDKEVLASQLLVLTGQRLAYALLHTQ 1339

  Fly  1261 SSQSTFLKIASVGHQLLAYLD-------NLKEP--MTENNIQIAAT 1297
            :.:         |.:|||.|.       ...:|  :.:.|:.|.||
Frog  1340 TKE---------GMELLARLPPTLCTWIKAMDPQELQKTNVPIDAT 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab3-GAP	NP_609544.2	RAB3GAP2_N	29..430	CDD:291327	144/438 (33%)
Rab3-GAP	NP_609544.2	RAB3GAP2_C	710..1319	CDD:291328	176/641 (27%)
rab3gap2	NP_001120595.1	RAB3GAP2_N	89..520	CDD:291327	144/438 (33%)
rab3gap2	NP_001120595.1	RAB3GAP2_C	801..1388	CDD:291328	172/632 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2735
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40842
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1916
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29182at33208
OrthoFinder	1	1.000	-	-		FOG0005758
OrthoInspector	1	1.000	-	-		oto103669
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060