DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JhI-21 and MUP3

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_011827.1	Gene:	MUP3 / 856349	SGDID:	S000001028	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	482	Identity:	119/482 - (24%)
Similarity:	212/482 - (43%)	Gaps:	110/482 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTESVGSSLL---IWLTCGILSTIGALCYAELGTC 100
            |.|.:.:.|.:.|..|:|||||..|:.:.:.|.  |:.|:   ||:....::..|...:.|.|:.
Yeast    63 RHLGVFSTVVLFVSRIMGSGIFAVPSVILLNTG--GNKLIYFAIWVFSAAIAFAGLYLFLEFGSW 125

  Fly   101 ITRSGGDYAYLLVSF-GPLVGFLRLWIALLIIRPTTQTIVALS----FAHYAVKPFFPECDPPQN 160
            |.:|||...:|..|| .|     ||.|:::....:..|..||:    |..|.:..|....|....
Yeast   126 IPKSGGRKNFLERSFERP-----RLLISVVFSCYSVLTGYALTGSIVFGKYVLSAFGVTDDSWSK 185

  Fly   161 AVKLLAAICLTLLTTINCLSVKVSMKVQDVFTVGKLLALIMIILSGLY----YMATGELENFRNP 221
            .|.:...|...|   |:.:||:..:.:|:.....||:.::::..:|||    |.:||::     .
Yeast   186 YVSISFIIFAVL---IHGVSVRHGVFIQNALGGLKLIMIVLMCFAGLYTLFFYKSTGQV-----A 242

  Fly   222 W---------EGIYTARNIGYAFYSGLFAFGGWNYLNFVTEELQDPYKNLPRAIWIAMPLVTSIY 277
            |         :.:.:..:|..||.|..|.|.||:.::.||.|:::|.|.|..:..:::.:....|
Yeast   243 WDLPVTQVEKDSLLSVSSIATAFISSFFCFSGWDTVHTVTSEIKNPVKTLKVSGPLSLIICFVCY 307

  Fly   278 VLVNLAYFAVVNKPEMLSS--LAVAVTFGNRVFGP------LAFMVPIFVALSTFGGVNGVLFTS 334
            .::|:||..|:...|::|:  |..:|.| .::|||      :||.    :|:|....:..|:::.
Yeast   308 TMMNVAYLKVLTYEEIVSAGPLVGSVLF-TKLFGPRVGGKFIAFS----IAISAASNILVVIYSI 367

  Fly   335 ARLFATGAQEGHLPKFFQLFHVKQ---QTPIPSLI---FTCLMSLLMLLTDNVYQLINYFSSV-- 391
            :|:.....:||:||  |.:...|.   ..|:||:.   |..:..:|:|..:.  :..||..|:
Yeast   368 SRVNQEIFKEGYLP--FSIHMSKNWPFDAPLPSISLCGFITIAWILILPKEG--ESFNYLVSMDG 428

  Fly   392 ----LWLSVVASIAGMLW-LRHKR------------------------------PDLPR-----P 416
                .:|.:|| |...:| .:||.                              |.|.|     |
Yeast   429 YGNQFFLLLVA-IGLFIWRFKHKNEVPEIRASTFGVLAIITLSLYMLMAPFFADPSLNRVGFLPP 492

  Fly   417 IKVHLALPITFMVSC-----VTLVLLP 438
            .::   :.:..:|:|     |..||||
Yeast   493 YQI---MSLLVIVACFFFWLVKFVLLP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	119/482 (25%)
MUP3	NP_011827.1	2A0308	40..538	CDD:273332	119/482 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I1105
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	139	1.000	Inparanoid score	I1189
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	1	1.000	-	-		mtm9156
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.970