DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JhI-21 and SLC7A5

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_016879224.1	Gene:	SLC7A5 / 8140	HGNCID:	11063	Length:	509	Species:	Homo sapiens

Alignment Length:	448	Identity:	238/448 - (53%)
Similarity:	319/448 - (71%)	Gaps:	5/448 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PADGEEKIVLKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTESVGSSLLIWLTCGILSTIGAL 92
            ||...|.:.|:|.:||:||||||||||||||||:.||||.....|.|.:|::|..||:.|.:|||
Human    37 PAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGAL 101

  Fly    93 CYAELGTCITRSGGDYAYLLVSFGPLVGFLRLWIALLIIRPTTQTIVALSFAHYAVKPFFPECDP 157
            |||||||.|::|||||||:|..:|.|..||:|||.||||||::|.||||.||.|.:||.||.|..
Human   102 CYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPV 166

  Fly   158 PQNAVKLLAAICLTLLTTINCLSVKVSMKVQDVFTVGKLLALIMIILSGLYYMATGELENFRNP- 221
            |:.|.||:|.:|:.|||.:||.|||.:.:|||.|...|||||.:|||.|...:..|::.|. :|
Human   167 PEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNL-DPN 230

  Fly   222 --WEGI-YTARNIGYAFYSGLFAFGGWNYLNFVTEELQDPYKNLPRAIWIAMPLVTSIYVLVNLA 283
              :||. ....||..|.||||||:||||||||||||:.:||:|||.||.|::|:||.:|||.|||
Human   231 FSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLA 295

  Fly   284 YFAVVNKPEMLSSLAVAVTFGNRVFGPLAFMVPIFVALSTFGGVNGVLFTSARLFATGAQEGHLP 348
            ||..::..:||||.||||.|||...|.:::::|:||.||.||.|||.||||:|||..|::|||||
Human   296 YFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLP 360

  Fly   349 KFFQLFHVKQQTPIPSLIFTCLMSLLMLLTDNVYQLINYFSSVLWLSVVASIAGMLWLRHKRPDL 413
            ....:.|.:..||:|||:|||:|:||...:.:::.:||:||...||.|..:|.||:||||::|:|
Human   361 SILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPEL 425

  Fly   414 PRPIKVHLALPITFMVSCVTLVLLPNLEEPQNLLIGIGITLAGIPFYYAFIARKKKPK 471
            .|||||:||||:.|:::|:.|:.:...:.|....||..|.|:|:|.|:..:..|.|||
Human   426 ERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPK 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	238/448 (53%)
SLC7A5	XP_016879224.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55759
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.860