DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JhI-21 and SLC7A2

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001158243.1	Gene:	SLC7A2 / 6542	HGNCID:	11060	Length:	698	Species:	Homo sapiens

Alignment Length:	444	Identity:	111/444 - (25%)
Similarity:	193/444 - (43%)	Gaps:	95/444 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DGEEKIVLKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTESVGSSLLIWLTCGILSTIGALCY 94
            |..|...|.|.|:.::.:|:.||:.:|:|:::. .|.....:|..|.::.:|...:.|.:..|||
Human    63 DSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVL-AGEVAKADSGPSIVVSFLIAALASVMAGLCY 126

  Fly    95 AELGTCITRSGGDYAYLLVSFGPLVGFLRLWIALL--IIRPTT---------------------Q 136
            ||.|..:.::|..|.|..|:.|.|..|:..|..:|  :|..::                     :
Human   127 AEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLR 191

  Fly   137 TIVALSFAHYAVKP-FFPECDPPQNAVKLLAAICLTLLTT-INCLSVKVSMKVQDVFTVGKLLAL 199
            |...:::...|..| ||              |:||.||.. :....||.|..|..|||...:|.|
Human   192 TYFRMNYTGLAEYPDFF--------------AVCLILLLAGLLSFGVKESAWVNKVFTAVNILVL 242

  Fly   200 IMIILSGLYYMATGELENFRNPWE------------------GIYTARN-IGYAFYSGL------ 239
            :.::::|   ...|.:.|::...|                  .||.|.. :.|.|...|
Human   243 LFVMVAG---FVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATC 304

  Fly   240 -FAFGGWNYLNFVTEELQDPYKNLPRAIWIAMPLVTSIYVLVNLAYFAV-----VNKPEML---- 294
             :||.|::.:....||:::|.|.:|      :.:|||:.|.. :|||.|     :..|..|
Human   305 FYAFVGFDCIATTGEEVRNPQKAIP------IGIVTSLLVCF-MAYFGVSAALTLMMPYYLLDEK 362

  Fly   295 SSLAVAVTFGNRVFGPLAFMVPI--FVALSTFGGVNGVLFTSARLFATGAQEGHLPKFFQLFHVK 357
            |.|.||..:..  :||..::|..  ..||||  .:.|.:|...|:....|::|.|.|.....:.|
Human   363 SPLPVAFEYVG--WGPAKYVVAAGSLCALST--SLLGSIFPMPRVIYAMAEDGLLFKCLAQINSK 423

  Fly   358 QQTPIPSLIFTCLMSLLMLLTDNVYQLINYFS--SVLWLSVVASIAGMLWLRHK 409
            .:|||.:.:.:..::.||....::..|::..|  :::..|:||  |.:|.||::
Human   424 TKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVA--ACVLILRYQ 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	111/444 (25%)
SLC7A2	NP_001158243.1	2A0303	45..648	CDD:273330	111/444 (25%)
SLC7A2	NP_001158243.1	AA_permease_C	596..646	CDD:290617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920