DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JhI-21 and SLC7A1

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_016876202.1	Gene:	SLC7A1 / 6541	HGNCID:	11057	Length:	643	Species:	Homo sapiens

Alignment Length:	512	Identity:	121/512 - (23%)
Similarity:	212/512 - (41%)	Gaps:	117/512 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EKIVLKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTESVGSSLLI-WLTCGILSTIGALCYAE 96
            |:..|.|.|...:.||:.||:.:|:|:::....|  ..|:.|.:::| :|...:.|.:..|||.|
Human    24 EETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAV--ARENAGPAIVISFLIAALASVLAGLCYGE 86

  Fly    97 LGTCITRSGGDYAYLLVSFGPLVGFLRLWIALLIIRPTTQTIV---ALSFAHYAVKPF--FPECD 156
            .|..:.::|..|.|..|:.|.|..|:..|..:|.....|.::.   :.:|.....:|.  |....
Human    87 FGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTH 151

  Fly   157 PPQNAVKLL-------AAICLTLLTTINCLSVKVSMKVQDVFTVGKLLALIMIILSGLYYMATGE 214
            ...||..:|       |.|.:.:||.:..|.||.|..|..:||...:|.|..|::||   ...|.
Human   152 MTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSG---FVKGS 213

  Fly   215 LENFRNPWEGIYTARNIGYAF-----------------------YSGL--------FAFGGWNYL 248
            ::|    |:  .|..:.|...                       :||:        :||.|::.:
Human   214 VKN----WQ--LTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCI 272

  Fly   249 NFVTEELQDPYKNLPRAIWIAMPLVTSIYVLVNLA------YFAVVNK---PEML-------SSL 297
            ....||:::|.|.:|..|..::.:....|..|:.|      ||.:.|.   |:..       :..
Human   273 ATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKY 337

  Fly   298 AVAVTFGNRVFGPLAFMVPIFVALSTFGGVNGVLFTSARLFATGAQEGHLPKFFQLFHVKQQTPI 362
            ||||       |.|.       |||  ..:.|.:|...|:....|::|.|.||....:.:.:|||
Human   338 AVAV-------GSLC-------ALS--ASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPI 386

  Fly   363 PSLIFTCLMSLLMLLTDNVYQLINYFS--SVLWLSVVASIAGMLWLRHKRPDLPRPI-------- 417
            .:.:.:..::.:|....::..|::..|  ::|..|:||  |.:|.||: :|:.|..:
Human   387 IATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVA--ACVLVLRY-QPEQPNLVYQMASTSD 448

  Fly   418 ------KVHLA---------LPITFMVSCVTLVLLPNLEEPQ--NLLIGIGITLAGI 457
                  :..||         ||...|.|..|::...|:|..:  .|::.|..:|..:
Human   449 ELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEPSKISGLIVNISTSLIAV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	121/512 (24%)
SLC7A1	XP_016876202.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920