DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JhI-21 and SLC7A14

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_066000.2	Gene:	SLC7A14 / 57709	HGNCID:	29326	Length:	771	Species:	Homo sapiens

Alignment Length:	506	Identity:	110/506 - (21%)
Similarity:	205/506 - (40%)	Gaps:	102/506 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SLVEPTNGCAAPGNPNPADGEEKIVLKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTESVGSS 76
            |::|.|....|.|..          |.:.||.::.:::.||:.:|:|:::. :|: :..|..|..
Human    34 SMLEGTGTTTAHGTK----------LAQVLTTVDLISLGVGSCVGTGMYVV-SGL-VAKEMAGPG 86

  Fly    77 LLI-WLTCGILSTIGALCYAELGTCITR-SGGDYAYLLVSFGPLVGFLRLW-IALLIIRPTTQTI 138
            ::: ::...:.|.:..:||||.|..:.: :|..|.|..|:.|..|.|...| :.|..:..|....
Human    87 VIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGA 151

  Fly   139 VAL-----SFAHYAVKPFFPECDPPQNAV--------KLLAAICLTLLTTINCLSVKVSMKVQDV 190
            .||     |.|::.:..:..:.....|.:        .|||.:...::|.|..|.||.|:...:|
Human   152 SALSSMFDSLANHTISRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNV 216

  Fly   191 FTVGKLLALIMIILSGLY-----YMATGELENFRNPWEGIYTARNIGYAFYSGLFAFGGWNYLNF 250
            ..|..|...:.|:::||:     |.|.|:.  ..:.|.|:  .:.....||    ||.|::.:..
Human   217 LNVLNLAVWVFIMIAGLFFINGKYWAEGQF--LPHGWSGV--LQGAATCFY----AFIGFDIIAT 273

  Fly   251 VTEELQDPYKNLPRAIWIAMPLVTSIYVLVN-----LAYFAVVNKPEMLSSLAVAVTFGNRVFGP 310
            ..||.::|..::|.||..::.:..:.||.|:     :..:..::....|..:.||..|
Human   274 TGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLMEMFVAHGF------- 331

  Fly   311 LAFMVPIFVALSTFGGVN----GVLFTSARLFATGAQEGHLPKFFQLFHVKQQTPIPSLIFTCLM 371
              :.....||:.:..|:.    |.||...|:....|.:|.|.:|  |.||...|..|  :..|::
Human   332 --YAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRF--LAHVSSYTETP--VVACIV 390

  Fly   372 SLLMLLTDNVYQLINYFSSVLWLSVVASIAGMLWLRHKRPDLPRPIKVHLALPITFMVSCVTLVL 436
            |                         ..:|.:|.|.....||...:.:...|..|.:..||.|:.
Human   391 S-------------------------GFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLR 430

  Fly   437 LPNLEEPQNLLIGIGITLAGIPFYYAFIARKKKPKCYGRLSNSVVEICRAI 487
            .    :|::.:.|          :..|::.:...|..|.|::...|.|..:
Human   431 Y----QPESDIDG----------FVKFLSEEHTKKKEGILADCEKEACSPV 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	105/491 (21%)
SLC7A14	NP_066000.2	2A0303	48..677	CDD:273330	105/492 (21%)
		AA_permease_C	627..677	CDD:290617
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950