DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JhI-21 and Slc7a8

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_058668.1	Gene:	Slc7a8 / 50934	MGIID:	1355323	Length:	531	Species:	Mus musculus

Alignment Length:	484	Identity:	234/484 - (48%)
Similarity:	330/484 - (68%)	Gaps:	23/484 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PGNPNPADGEEK-----IVLKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTESVGSSLLIWLT 82
            ||:....:.|..     :.||:::.|::...||||.|||||||::|.||.....|||.:|::|:.
Mouse    16 PGSDTSPEAEASSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIV 80

  Fly    83 CGILSTIGALCYAELGTCITRSGGDYAYLLVSFGPLVGFLRLWIALLIIRPTTQTIVALSFAHYA 147
            .||::.:|||||||||..|.:|||||:|:...||.|.||||||||:|:|.||.|.::||:|::|.
Mouse    81 TGIITAVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYV 145

  Fly   148 VKPFFPECDPPQNAVKLLAAICLTLLTTINCLSVKVSMKVQDVFTVGKLLALIMIILSGLYYMAT 212
            ::|.||.|.||::.::|||||||.|||.:||.||:.:.:|||:||.||||||.:||:.|:..:..
Mouse   146 LQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICK 210

  Fly   213 GE---------LENFRNPWEGIYTARNIGYAFYSGLFAFGGWNYLNFVTEELQDPYKNLPRAIWI 268
            ||         .|||:.|..|:     :..||..|.||:||||:||:|||||.||||||||||:|
Mouse   211 GEFFWLEPKNAFENFQEPDIGL-----VALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFI 270

  Fly   269 AMPLVTSIYVLVNLAYFAVVNKPEMLSSLAVAVTFGNRVFGPLAFMVPIFVALSTFGGVNGVLFT 333
            ::||||.:||..|:||...::..|:|:|.|||||||.::.|.:|:::||.|||||||||||.|||
Mouse   271 SIPLVTFVYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFT 335

  Fly   334 SARLFATGAQEGHLPKFFQLFHVKQQTPIPSLIFTCLMSLLMLLTDNVYQLINYFSSVLWLSVVA 398
            |:|||..||:|||||....:.|||:.||||:|:||||.:||||:|.::|.||||...:.:|....
Mouse   336 SSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCLSTLLMLVTSDMYTLINYVGFINYLFYGV 400

  Fly   399 SIAGMLWLRHKRPDLPRPIKVHLALPITFMVSCVTLVLLPNLEEPQNLLIGIGITLAGIPFYYAF 463
            ::||.:.||.|:||:||||||.|..||.:::....|::.....||....||:.|.|.|:|.|:..
Mouse   401 TVAGQIVLRWKKPDIPRPIKVSLLFPIIYLLFWAFLLIFSLWSEPVVCGIGLAIMLTGVPVYFLG 465

  Fly   464 IARKKKPKCYGRLSNSVV----EICRAIF 488
            :..:.||||:.....|:.    ::|..::
Mouse   466 VYWQHKPKCFNDFIKSLTLVSQKMCVVVY 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	232/480 (48%)
Slc7a8	NP_058668.1	2A0308	1..497	CDD:273332	234/484 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.860