DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JhI-21 and Slc7a5

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_059049.1	Gene:	Slc7a5 / 50719	RGDID:	620639	Length:	512	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	242/467 - (51%)
Similarity:	324/467 - (69%)	Gaps:	8/467 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ADGE-EKIVLKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTESVGSSLLIWLTCGILSTIGAL 92
            ||.| |.:.|:|.:|||||||||||||||||||:.||||.....|.|.||::|..||:.|.:|||
  Rat    38 ADPEGEGVTLQRNITLINGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGAL 102

  Fly    93 CYAELGTCITRSGGDYAYLLVSFGPLVGFLRLWIALLIIRPTTQTIVALSFAHYAVKPFFPECDP 157
            |||||||.|::|||||||:|..:|.|..||:|||.||||||::|.||||.||.|.:||.||.|..
  Rat   103 CYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPV 167

  Fly   158 PQNAVKLLAAICLTLLTTINCLSVKVSMKVQDVFTVGKLLALIMIILSGLYYM----ATGELENF 218
            |:.|.||:|.:|:.|||.:||.|||.:.:|||.|...|||||.:|||.|...|    ..|:..|.
  Rat   168 PEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDIGQGDASNL 232

  Fly   219 RN--PWEGI-YTARNIGYAFYSGLFAFGGWNYLNFVTEELQDPYKNLPRAIWIAMPLVTSIYVLV 280
            ..  .:||. ....||..|.||||||:||||||||||||:.:||:|||.||.|::|:||.:|||.
  Rat   233 HQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLT 297

  Fly   281 NLAYFAVVNKPEMLSSLAVAVTFGNRVFGPLAFMVPIFVALSTFGGVNGVLFTSARLFATGAQEG 345
            |||||..::..:||:|.||||.|||...|.:::::|:||.||.||.|||.||||:|||..|::||
  Rat   298 NLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREG 362

  Fly   346 HLPKFFQLFHVKQQTPIPSLIFTCLMSLLMLLTDNVYQLINYFSSVLWLSVVASIAGMLWLRHKR 410
            |||....:.|.:..||:|||:|||:|:|:...:.:::.:||:||...||.|..:|.||:|||.|:
  Rat   363 HLPSILSMIHPQLLTPVPSLVFTCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKK 427

  Fly   411 PDLPRPIKVHLALPITFMVSCVTLVLLPNLEEPQNLLIGIGITLAGIPFYYAFIARKKKPKCYGR 475
            |:|.|||||:||||:.|:::|:.|:.:...:.|....||..|.|:|:|.|:..:..|.|||...:
  Rat   428 PELERPIKVNLALPVFFILACLFLIAVSFWKTPLECGIGFAIILSGLPVYFFGVWWKNKPKWILQ 492

  Fly   476 LSNSVVEICRAI 487
            :..||..:|:.:
  Rat   493 VIFSVTVLCQKL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	242/467 (52%)
Slc7a5	NP_059049.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		3/4 (75%)
Slc7a5	NP_059049.1	2A0308	23..511	CDD:273332	242/467 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55759
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.830