DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JhI-21 and Slc7a9

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001185944.1	Gene:	Slc7a9 / 30962	MGIID:	1353656	Length:	487	Species:	Mus musculus

Alignment Length:	451	Identity:	206/451 - (45%)
Similarity:	304/451 - (67%)	Gaps:	10/451 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTESVGSSLLIWLTCGILSTIGALCYAELGTCI 101
            |::::.|::|:.|||||||||||||:|..|...|||||..|:||..||||:|:||||:|||||.|
Mouse    26 LQKEVGLLSGICIIVGTIIGSGIFISPKSVLANTESVGPCLIIWAACGILATLGALCFAELGTMI 90

  Fly   102 TRSGGDYAYLLVSFGPLVGFLRLWIALLIIRPTTQTIVALSFAHYAVKPFFPECDPPQNAVKLLA 166
            |:|||:|.||:.:|||:..:|..|.:|::::|::..|:.|||:.|....|:..|.||...|||||
Mouse    91 TKSGGEYPYLMEAFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYSGCKPPAVVVKLLA 155

  Fly   167 AICLTLLTTINCLSVKVSMKVQDVFTVGKLLALIMIILSGLYYMATGELENFRNPWEGIYTARN- 230
            |..:..:||:|.|||::...||:|||..|::.:.:||:|||.::|.|.::||:|.:||..|:..
Mouse   156 AAAILFITTVNALSVRLGSYVQNVFTAAKMVIVAIIIISGLVFLAQGNVKNFQNSFEGTQTSVGA 220

  Fly   231 IGYAFYSGLFAFGGWNYLNFVTEELQDPYKNLPRAIWIAMPLVTSIYVLVNLAYFAVVNKPEMLS 295
            |..|||:||:|:.|||.||::||||::||:|||.||.|.:||||..|:|:|:|||.|:...|:|.
Mouse   221 ISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFTVMTPTELLQ 285

  Fly   296 SLAVAVTFGNRVFGPLAFMVPIFVALSTFGGVNGVLFTSARLFATGAQEGHLPKFFQLFHVKQQT 360
            |.|||||||:||..|.:::||:|||.||.|..||..||:.||.....:|||:.|......||:.|
Mouse   286 SQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVKRLT 350

  Fly   361 PIPSLIFTCLMSLLMLLTDNVYQLINYFSSVLWLSVVASIAGMLWLRHKRPDLPRPIKVHLALPI 425
            |.|:|||..:::::.::..::..|:||||...||....:|.|::.:|..|.||.|||||.|.:||
Mouse   351 PAPALIFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILGLVVMRFTRKDLERPIKVPLFIPI 415

  Fly   426 TFMVSCVTLVLLPNLEEPQ-NLLIGIGITLAGIPFYYAFIARKKKPKCYG---RLSNSVVE 482
            ..::..:.|:|.|.:.||. ..|..:...|:|:.||:.|:..|     :|   |:|..|.:
Mouse   416 IVILVSLFLILAPIISEPAWEYLYCVLFILSGLIFYFLFVYYK-----FGWAQRISRPVTK 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	206/451 (46%)
Slc7a9	NP_001185944.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
Slc7a9	NP_001185944.1	2A0308	26..484	CDD:273332	206/451 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1752
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.710