DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JhI-21 and Slc7a3

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_058913.1	Gene:	Slc7a3 / 29485	RGDID:	68342	Length:	619	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	122/454 - (26%)
Similarity:	186/454 - (40%)	Gaps:	116/454 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GEEKIVLKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTESVGSSLLI-WLTCGILSTIGALCY 94
            ||.:  |.|.|:.::.||:.||:.:|:|:::....|  ..|..|.|::| :|...:.|.:..|||
  Rat    24 GETR--LARCLSTLDLVALGVGSTLGAGVYVLAGEV--AKEKAGPSIVICFLVAALSSVLAGLCY 84

  Fly    95 AELGTCITRSGGDYAYLLVSFGPLVGFLRLWIALLI-----------------------IRPTTQ 136
            ||.|..:..||..|.|..|:.|.|..|...|..:|.                       |..|.:
  Rat    85 AEFGARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISQTLK 149

  Fly   137 TIVALSFAHYAVKPFFPECDPPQNAVKLLAAICLTLLTTINCLSVKVSMKVQDVFTVGKLLALIM 201
            ..:.|:..|...:  :|:         ..|...:.|||.:..|....|..|..|||...||.|..
  Rat   150 GTILLNMPHVLAE--YPD---------FFALALVLLLTGLLVLGANESGLVTKVFTGMNLLVLGF 203

  Fly   202 IILSGLYYMATGELENFR---------------------------NPW--EGIYTARNIGYAFYS 237
            :|:||   ...|||.|::                           .|:  |||  .|.....||
  Rat   204 VIISG---FIKGELRNWKLTKEDYCLTMSESNGTCSLDSMGSGGFMPFGLEGI--LRGAATCFY- 262

  Fly   238 GLFAFGGWNYLNFVTEELQDPYKNLPRAIWIAMPLVTSIYVLVNLAYFAVVN-----------KP 291
               ||.|::.:....||.|:|.:::|..|.|::.:..       ||||.|.:           :|
  Rat   263 ---AFVGFDCIATTGEEAQNPQRSIPMGIVISLSICF-------LAYFGVSSALTLMMPYYKLQP 317

  Fly   292 EMLSSLAVAVTFGNRVFGPLAFMVPI--FVALSTFGGVNGVLFTSARLFATGAQEGHLPKFFQLF 354
            |  |.|..|.|:..  :.|..::|.|  ..||||  .:.|.:|...|:....|::|.|.:.....
  Rat   318 E--SPLPEAFTYVG--WEPARYLVAIGSLCALST--SLLGSMFPMPRVIYAMAEDGLLFRVLARV 376

  Fly   355 HVKQQTPI----PSLIFTCLMSLLMLLTDNVYQLINYFS--SVLWLSVVASIAGMLWLRHKRPD 412
            |....|||    .|.:....|:.|..|||    |::..|  ::|..|:| ||. :|.||: :||
  Rat   377 HNGTHTPIVATVVSGVIAAFMAFLFELTD----LVDLMSIGTLLAYSLV-SIC-VLILRY-QPD 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	122/454 (27%)
Slc7a3	NP_058913.1	2A0303	4..591	CDD:273330	122/454 (27%)
Slc7a3	NP_058913.1	AA_permease_C	<551..589	CDD:290617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010