DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JhI-21 and SLC7A8

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_036376.2	Gene:	SLC7A8 / 23428	HGNCID:	11066	Length:	535	Species:	Homo sapiens

Alignment Length:	479	Identity:	233/479 - (48%)
Similarity:	328/479 - (68%)	Gaps:	17/479 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RYANGVTTSLVEPTNGCAAPGNPNPADGEEKIVLKRKLTLINGVAIIVGTIIGSGIFIAPTGVFI 68
            |:.|  .|....|..| .:..:|....|...:.||:::.|::...||||.|||||||::|.||..
Human     6 RHRN--NTEKKHPGGG-ESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLE 67

  Fly    69 YTESVGSSLLIWLTCGILSTIGALCYAELGTCITRSGGDYAYLLVSFGPLVGFLRLWIALLIIRP 133
            ...|||.:|::|:..|.::.:|||||||||..|.:|||||:|:...||.|.||||||||:|:|.|
Human    68 NAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYP 132

  Fly   134 TTQTIVALSFAHYAVKPFFPECDPPQNAVKLLAAICLTLLTTINCLSVKVSMKVQDVFTVGKLLA 198
            |.|.::||:|::|.::|.||.|.||::.::|||||||.|||.:||.||:.:.:|||:||.|||||
Human   133 TNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLA 197

  Fly   199 LIMIILSGLYYMATGE---------LENFRNPWEGIYTARNIGYAFYSGLFAFGGWNYLNFVTEE 254
            |.:||:.|:..:..||         .|||:.|..|:     :..||..|.||:||||:||:||||
Human   198 LALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGL-----VALAFLQGSFAYGGWNFLNYVTEE 257

  Fly   255 LQDPYKNLPRAIWIAMPLVTSIYVLVNLAYFAVVNKPEMLSSLAVAVTFGNRVFGPLAFMVPIFV 319
            |.||||||||||:|::||||.:||..|:||...::..|:|:|.|||||||.::.|.:|:::||.|
Human   258 LVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISV 322

  Fly   320 ALSTFGGVNGVLFTSARLFATGAQEGHLPKFFQLFHVKQQTPIPSLIFTCLMSLLMLLTDNVYQL 384
            ||||||||||.||||:|||..||:|||||....:.|||:.||||:|:|||:.:||||:|.::|.|
Human   323 ALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTL 387

  Fly   385 INYFSSVLWLSVVASIAGMLWLRHKRPDLPRPIKVHLALPITFMVSCVTLVLLPNLEEPQNLLIG 449
            |||...:.:|....::||.:.||.|:||:|||||::|..||.:::....|::.....||....||
Human   388 INYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIG 452

  Fly   450 IGITLAGIPFYYAFIARKKKPKCY 473
            :.|.|.|:|.|:..:..:.||||:
Human   453 LAIMLTGVPVYFLGVYWQHKPKCF 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	227/456 (50%)
SLC7A8	NP_036376.2	2A0308	1..497	CDD:273332	233/479 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..535
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.860