DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JhI-21 and SLC7A13

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_620172.2	Gene:	SLC7A13 / 157724	HGNCID:	23092	Length:	470	Species:	Homo sapiens

Alignment Length:	485	Identity:	156/485 - (32%)
Similarity:	254/485 - (52%)	Gaps:	34/485 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DGEEKIVLKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYT-ESVGSSLLIWLTCGILSTIGALC 93
            |..|||.|||......|.:.::..|||:|||::|.||..|: .:||.||.:|..|.||:....||
Human     2 DRGEKIQLKRVFGYWWGTSFLLINIIGAGIFVSPKGVLAYSCMNVGVSLCVWAGCAILAMTSTLC 66

  Fly    94 YAELGTCITRSGGDYAYLLVSFGPLVGFLRLWIALLIIRPTTQTIV---ALSFAHYAVKPFFPEC 155
            .||:......||..|.:|...||..|.||.||.:|.:    ...:|   ||..|.|:::||||.|
Human    67 SAEISISFPCSGAQYYFLKRYFGSTVAFLNLWTSLFL----GSGVVAGQALLLAEYSIQPFFPSC 127

  Fly   156 DPPQNAVKLLAAICLTLLTTINCLSVKVSMKVQDVFTVGKLLALIMIILSGLYYMATGELEN--- 217
            ..|:...|.||...|.::..:....||....:|...:|.|:..|..|.|:|:.::..|:.||
Human   128 SVPKLPKKCLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVER 192

  Fly   218 FRNPWEG-IYTARNIGYAFYSGLFAFGGWNYLNFVTEELQDPYKNLPRAIWIAMPLVTSIYVLVN 281
            |:|.::. :....::..|.:.|.||:.|......:..||:.|...:|:.|:.|:||||.:|:|||
Human   193 FQNAFDAELPDISHLIQAIFQGYFAYSGGACFTLIAGELKKPRTTIPKCIFTALPLVTVVYLLVN 257

  Fly   282 LAYFAVVNKPEMLSSLAVAVTFGNRVFGPLAFMVPIFVALSTFGGVNGVLFTSARLFATGAQEGH 346
            ::|..|:...|:|||.|||:|:.:|.|..||:::|..::.|.|..:...:|.|:|.....:|||.
Human   258 ISYLTVLTPREILSSDAVAITWADRAFPSLAWIMPFAISTSLFSNLLISIFKSSRPIYLASQEGQ 322

  Fly   347 LPKFFQLFHVKQQTPIPSLIFTCLMSLLMLLTDNVYQLINY--FSSVLWLSVVASIAGMLWLRHK 409
            ||..|...: ...:|..:::....:..|.::..::..||||  |:..|| |::..| |:|..|::
Human   323 LPLLFNTLN-SHSSPFTAVLLLVTLGSLAIILTSLIDLINYIFFTGSLW-SILLMI-GILRRRYQ 384

  Fly   410 RPDLPRPIKVHLALPITFMVSCVTLVLLPNLEEPQ-NLLIGIGITLAGIPFYYAFIARK------ 467
            .|:|..|.||.|:.|:..:|..|.||::|.::.|. :.:..:.:.|:|:.||...|..|
Human   385 EPNLSIPYKVFLSFPLATIVIDVGLVVIPLVKSPNVHYVYVLLLVLSGLLFYIPLIHFKIRLAWF 449

  Fly   468 KKPKCYGRLSNSVVEICRAIFNTTIIESNE 497
            :|..||.:|          :||..:.:.:|
Human   450 EKMTCYLQL----------LFNICLPDVSE 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	155/480 (32%)
SLC7A13	NP_620172.2	AA_permease_2	16..398	CDD:290254	129/388 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820