DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JhI-21 and Slc7a12

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_543128.1	Gene:	Slc7a12 / 140918	MGIID:	2156159	Length:	465	Species:	Mus musculus

Alignment Length:	480	Identity:	121/480 - (25%)
Similarity:	222/480 - (46%)	Gaps:	40/480 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LKRKLTLINGVAIIVGTIIGSGIFIAPTGVFIYTE-SVGSSLLIWLTCGILSTIGALCYAELGTC 100
            |.|.|.:.:...|:....:|:|||:.|..|..|:. ::..||.||..||:||.:.|||.||:.|.
Mouse     3 LLRALGVFHVSMILFSATLGTGIFVTPKAVLKYSSLNIPVSLSIWAGCGLLSIMSALCNAEIATT 67

  Fly   101 ITRSGGDYAYLLVSFGPLVGFLRLWIALLIIRPTTQTIVALSFAHY-------------AVKPFF 152
            ...||..|.:|..:.|..|.||.|||.|              |||:             .::.|:
Mouse    68 YPLSGASYYFLKRTLGSSVAFLSLWIKL--------------FAHFLGIGAQCLLIATSVIQCFY 118

  Fly   153 PECDPPQNAVKLLAAICLTLLTTINCLSVKVSMKVQDVFTVGKLLALIMIILSGLYYMATGELEN 217
            ..|..|:...|.||...|.....::...:|.......|.:..||..|.:|.|:.|  :..|:.||
Mouse   119 SGCPAPELPTKCLALAILWSFGIVSARGIKTVAWFNTVSSFIKLSVLCLISLTVL--LVNGKKEN 181

  Fly   218 ---FRNPWEG-IYTARNIGYAFYSGLFAFGGWNYLNFVTEELQDPYKNLPRAIWIAMPLVTSIYV 278
               |.|..:. :..|..|..|.....:::.|.:.|..:..|::.|.:.:|:.:...:.:||.:|:
Mouse   182 VSRFENALDAELPNASQIADAILQVSYSYLGSSVLIVIAGEIKRPTETIPKTLIYGISIVTVLYL 246

  Fly   279 LVNLAYFAVVNKPEMLSSLAVAVTFGNRVFGPLAFMVPIFVALSTFGGVNGVLFTSARLFATGAQ 343
            |.|::|.||:...|::.|.:|.||:.||||..:.::....::....|.|:..:.:::|:|.:.:|
Mouse   247 LTNISYLAVLTSQEIIFSDSVGVTWMNRVFPSIQWISSFLISAFLLGSVSCGIVSASRVFYSASQ 311

  Fly   344 EGHLPKFFQLFHVKQQTPIPSLIFTCLMSLLMLLTDNVYQLINYFSSVLWLSVVASIAGMLWLRH 408
            ||..|..:.:.: ...:|..:.|...::|.:.:::.::..|:.|.|...:...:..:.|:|.:|:
Mouse   312 EGEFPSIYSMLN-DHHSPAVADIQIVILSSVAIISSSIIYLVKYVSLGSFCINLLQMIGLLKIRY 375

  Fly   409 KRPDLPRPIKVHLALPITFMVSCVTLVLLPNLEEPQ-NLLIGIGITLAGIPFYYAFIARKKKPKC 472
            :.||:|||.||.|......:...:.|:..|.::.|. ..:..:.....|...|:..........|
Mouse   376 QNPDIPRPYKVWLPFIFGSIALSLFLIFTPVIQSPSIEHVYQVVFLFCGFLCYWLQANLNGHATC 440

  Fly   473 YGRLSNSVVEICRAIFNTTIIESNE 497
            :    :::...|:.:||.:..|..|
Mouse   441 F----DTITCYCQLLFNISPSEDPE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	119/475 (25%)
Slc7a12	NP_543128.1	AA_permease_2	7..412	CDD:290254	111/421 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820