DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JhI-21 and slc7a8a

DIOPT Version :9

Sequence 1:	NP_001245996.1	Gene:	JhI-21 / 34624	FlyBaseID:	FBgn0028425	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001258826.1	Gene:	slc7a8a / 100007704	ZFINID:	ZDB-GENE-121120-2	Length:	531	Species:	Danio rerio

Alignment Length:	514	Identity:	240/514 - (46%)
Similarity:	336/514 - (65%)	Gaps:	20/514 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTD--RYANGVTTSLVEPTNGCAAPGNPNPADGEEKIVLKRKLTLINGVAIIVGTIIGSGIFIAP 63
            |||  |.......|......|.|..||    ...:.:.||:::.|::...||||.|||||||::|
Zfish     1 MTDGPRQRGSAAPSTASEDGGAADTGN----TAGQSVALKKEIGLVSACGIIVGNIIGSGIFVSP 61

  Fly    64 TGVFIYTESVGSSLLIWLTCGILSTIGALCYAELGTCITRSGGDYAYLLVSFGPLVGFLRLWIAL 128
            .||.....|||.:|::|:..||::.||||||||||..|.:|||||:|:...||.|.||||||||:
Zfish    62 KGVLENASSVGLALIVWILTGIITAIGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAV 126

  Fly   129 LIIRPTTQTIVALSFAHYAVKPFFPECDPPQNAVKLLAAICLTLLTTINCLSVKVSMKVQDVFTV 193
            |:|.||.|.::||:|::|.::|.||.|.||:|.:::||||||.|||.:||.||:.:.:||||||.
Zfish   127 LVIYPTNQAVIALTFSNYVLQPLFPTCFPPENGLRILAAICLLLLTWVNCSSVRWATRVQDVFTA 191

  Fly   194 GKLLALIMIILSGLYYMATGE---LE--NFRNPWEGIYTARNIGYAFYSGLFAFGGWNYLNFVTE 253
            |||||||:||:.|:..:..||   ||  |...|::. |....|..||..|.||:||||:||:|||
Zfish   192 GKLLALILIIIMGIVQICKGEYYWLEPANAFEPFQD-YDVGLIALAFLQGSFAYGGWNFLNYVTE 255

  Fly   254 ELQDPYKNLPRAIWIAMPLVTSIYVLVNLAYFAVVNKPEMLSSLAVAVTFGNRVFGPLAFMVPIF 318
            ||.|||.||||||:|::||||.:||..|:||...::..|:|:|.|||||||.::.|.:::::||.
Zfish   256 ELVDPYVNLPRAIFISIPLVTFVYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMSWIMPIS 320

  Fly   319 VALSTFGGVNGVLFTSARLFATGAQEGHLPKFFQLFHVKQQTPIPSLIFTCLMSLLMLLTDNVYQ 383
            |||||||||||.||||:|||..||:|||||....:.|||:.||||:|:|||:.:||||.|.::|.
Zfish   321 VALSTFGGVNGSLFTSSRLFFAGAREGHLPSLLAMIHVKRCTPIPALLFTCISTLLMLCTSDMYT 385

  Fly   384 LINYFSSVLWLSVVASIAGMLWLRHKRPDLPRPIKVHLALPITFMVSCVTLVLLPNLEEPQNLLI 448
            ||||...:.:|....::||.:.||.|:||:.||||:.|..|:.:::....|::.....||....|
Zfish   386 LINYVGFINYLFYGVTVAGQIVLRIKQPDMHRPIKISLVWPVIYLLFWAFLLIFSLYSEPVVCGI 450

  Fly   449 GIGITLAGIPFYYAFIARKKKPKCYGRLSNSVV----EICRAIFNTTII----ESNEAI 499
            |:.|.|.|:|.|:..:....||:|:....:.:.    :.|..::....:    ||.|.|
Zfish   451 GLAIMLTGVPVYFLGVYWDNKPQCFNTFVDKMTYLGQKFCVVVYPMEEVKKTDESAEGI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JhI-21	NP_001245996.1	AA_permease_2	27..494	CDD:330980	227/479 (47%)
slc7a8a	NP_001258826.1	2A0308	1..497	CDD:273332	236/500 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860