DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plzf and ZBTB24

DIOPT Version :9

Sequence 1:NP_001285862.1 Gene:Plzf / 34622 FlyBaseID:FBgn0032401 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_055612.2 Gene:ZBTB24 / 9841 HGNCID:21143 Length:697 Species:Homo sapiens


Alignment Length:583 Identity:126/583 - (21%)
Similarity:211/583 - (36%) Gaps:173/583 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LHQPLHS-KVSNYLNNQRRTGQFCDLLLELDSDDSLSLSVHF----CVLAAQSQFINSNQKQQQF 72
            :|...|| .|.....:||:.|..||:.|.::       :|||    .:|||.|::.:     ..|
Human    14 VHSDAHSDTVLASFEDQRKKGFLCDITLIVE-------NVHFRAHKALLAASSEYFS-----MMF 66

  Fly    73 SIHNPL--KITIRNFSCTQCLHTIVDFFYEDLVSVSKEHELHFRELAQILAVTELLNLYQL---- 131
            :....:  .|.:...........:::|.|...:..|:      :...||||..:.|.:|.|    
Human    67 AEEGEIGQSIYMLEGMVADTFGILLEFIYTGYLHASE------KSTEQILATAQFLKVYDLVKAY 125

  Fly   132 ----------------------------------QPLGEAK-------EATEIPAPGEAQ----- 150
                                              :..|..|       |.:|:.|..|.|     
Human   126 TDFQNNHSSPKPTTLNTAGAPVVVISNKKNDPPKRKRGRPKKVNTLQEEKSELAAEEEIQLRVNN 190

  Fly   151 ------------------------------PNPDPEKKAEAVFENRQSYF-KLKNPRAVKSS-SK 183
                                          |..:|.::.|...|..::|. |.::.:|.:|. ||
Human   191 SVQNRQNFVVKGDSGVLNEQIAAKEKEESEPTCEPSREEEMPVEKDENYDPKTEDGQASQSRYSK 255

  Fly   184 VNYCIGCDFKCYQVQKMIEHMGSCE--------PS--HLICSLCEVGFLDWREYD----THLRRH 234
            .........|.|::....|..||.:        |.  ...|..|...|    :|:    .|.|.|
Human   256 RRIWRSVKLKDYKLVGDQEDHGSAKRICGRRKRPGGPEARCKDCGKVF----KYNHFLAIHQRSH 316

  Fly   235 SGDLRKPFFCLQCGIRFNTRAALLVHQPKHSTETPHICPHCGKGFKWKQGLSNHILVHNPEKQML 299
            :|:  :||.|.:||..|..:.:|.||...|:.|.|:.|..|.|....|..|..|:.:|:.:|...
Human   317 TGE--RPFKCNECGKGFAQKHSLQVHTRMHTGERPYTCTVCSKALTTKHSLLEHMSLHSGQKSFT 379

  Fly   300 CDVCGYSTTHMKALKSHKLLHTGEF-----------------------------FACTVSGCKHR 335
            ||.||...:..:.||||..:|||..                             |.|.:.|....
Human   380 CDQCGKYFSQNRQLKSHYRVHTGHSLPECKDCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFT 444

  Fly   336 ANRKENLKLHIETHKQGRDFICEVCGCKFSQSKNLKRHALKHTENGPNRYKCQLCGFSSHRSDKM 400
            |  |.:|:.||..|:..:.:.|.:||..||.|...:||.:.||  |...:.|..|.....|.|.:
Human   445 A--KSSLQTHIRIHRGEKPYSCGICGKSFSDSSAKRRHCILHT--GKKPFSCPECNLQFARLDNL 505

  Fly   401 KEHVQRVHTEKPVQLELSETVDSSFPDD---------FELPVIETSPKKKPKSVKSKTIRNVN 454
            |.|: ::|:::....:.|....||..::         ::|   .||.:::.:.:.:.::.|:|
Human   506 KAHL-KIHSKEKHASDASSISGSSNTEEVRNILQLQPYQL---STSGEQEIQLLVTDSVHNIN 564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlzfNP_001285862.1 COG5048 <193..403 CDD:227381 70/252 (28%)
C2H2 Zn finger 214..234 CDD:275368 6/23 (26%)
C2H2 Zn finger 244..264 CDD:275368 7/19 (37%)
C2H2 Zn finger 272..292 CDD:275368 6/19 (32%)
C2H2 Zn finger 300..320 CDD:275368 8/19 (42%)
C2H2 Zn finger 330..349 CDD:275368 6/18 (33%)
C2H2 Zn finger 357..377 CDD:275368 8/19 (42%)
C2H2 Zn finger 387..408 CDD:275368 6/20 (30%)
ZBTB24NP_055612.2 BTB 27..133 CDD:306997 25/123 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 131..176 3/44 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..254 8/44 (18%)
C2H2 Zn finger 296..316 CDD:275368 6/23 (26%)
COG5048 <321..480 CDD:227381 46/160 (29%)
C2H2 Zn finger 324..344 CDD:275368 7/19 (37%)
C2H2 Zn finger 352..372 CDD:275368 6/19 (32%)
C2H2 Zn finger 380..400 CDD:275368 8/19 (42%)
C2H2 Zn finger 408..428 CDD:275368 0/19 (0%)
C2H2 Zn finger 436..456 CDD:275368 7/21 (33%)
C2H2 Zn finger 464..480 CDD:275368 6/15 (40%)
C2H2 Zn finger 492..512 CDD:275368 6/20 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 652..697
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 161 1.000 Inparanoid score I4231
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.050

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