DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and ZNF143

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_005253178.1	Gene:	ZNF143 / 7702	HGNCID:	12928	Length:	653	Species:	Homo sapiens

Alignment Length:	273	Identity:	75/273 - (27%)
Similarity:	113/273 - (41%)	Gaps:	42/273 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 DPEKKAEAVFENRQSYFKLKNPRAVKSSSKVNYCIGCDFKCYQVQKMIEHMGSCEPSHLICSLCE 218
            :.|||.:.|.:...:....|:.::.:.:.:..| .||. |.|..           ..||
Human   224 EQEKKMQIVLQGHATRVTAKSQQSGEKAFRCEY-DGCG-KLYTT-----------AHHL------ 269

  Fly   219 VGFLDWREYDTHLRRHSGDLRKPFFC--LQCGIRFNTRAALLVHQPKHSTETPHIC--PHCGKGF 279
                     ..|.|.|:||  :|:.|  ..||..|.|...|..|...|:.|.|:.|  .:|.|.|
Human   270 ---------KVHERSHTGD--RPYQCEHAGCGKAFATGYGLKSHVRTHTGEKPYRCSEDNCTKSF 323

  Fly   280 KWKQGLSNHILVHNPEKQMLC--DVCGYSTTHMKALKSHKLLHTGEF-FACTVSGCKHRANRKEN 341
            |....|..||..|..|:...|  :.||.|.|.....|.|...||||. :.||..||........|
Human   324 KTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHVRTHTGERPYYCTEPGCGRAFASATN 388

  Fly   342 LKLHIETHKQGRDFICEVCGC--KFSQSKNLKRHALKHTENGPNRYKCQLCGFSSHRSDKMKEHV 404
            .|.|:..|...:.::|.|.||  :|::..:|.:|.:.||.:.|  |.|..||.:..:...:..|.
Human   389 YKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKP--YNCNHCGKTYKQISTLAMHK 451

  Fly   405 QRVHTE-KPVQLE 416
            :..|.: :|::.|
Human   452 RTAHNDTEPIEEE 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	63/218 (29%)
		C2H2 Zn finger	214..234	CDD:275368	2/19 (11%)
		C2H2 Zn finger	244..264	CDD:275368	7/21 (33%)
		C2H2 Zn finger	272..292	CDD:275368	8/21 (38%)
		C2H2 Zn finger	300..320	CDD:275368	7/21 (33%)
		C2H2 Zn finger	330..349	CDD:275368	5/18 (28%)
		C2H2 Zn finger	357..377	CDD:275368	7/21 (33%)
		C2H2 Zn finger	387..408	CDD:275368	4/20 (20%)
ZNF143	XP_005253178.1	Trp-synth-beta_II	<97..207	CDD:294246
		C2H2 Zn finger	254..276	CDD:275368	9/49 (18%)
		zf-H2C2_2	268..295	CDD:290200	12/43 (28%)
		COG5048	279..>337	CDD:227381	20/59 (34%)
		C2H2 Zn finger	284..306	CDD:275368	7/21 (33%)
		zf-H2C2_2	299..325	CDD:290200	9/25 (36%)
		zf-C2H2_8	314..429	CDD:292531	38/114 (33%)
		C2H2 Zn finger	314..336	CDD:275368	8/21 (38%)
		zf-H2C2_2	328..355	CDD:290200	9/26 (35%)
		C2H2 Zn finger	344..366	CDD:275368	7/21 (33%)
		zf-H2C2_2	360..385	CDD:290200	10/24 (42%)
		C2H2 Zn finger	374..396	CDD:275368	7/21 (33%)
		zf-H2C2_2	388..414	CDD:290200	8/25 (32%)
		C2H2 Zn finger	404..426	CDD:275368	7/21 (33%)
		C2H2 Zn finger	434..453	CDD:275368	4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000