DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and ZNF142

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	469	Identity:	116/469 - (24%)
Similarity:	177/469 - (37%)	Gaps:	116/469 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 HFCVLAAQSQFINSNQKQQQFSIHNPLKITIRNFSCTQCLHTIVDFFYEDLVSVSKEHEL-HFRE 115
            |||.|...|.::..:..:...|.|.....    |:|:||   ...|..|   :..|:|.| ...|
Human  1457 HFCPLCDYSGYLRHDITRHVNSCHQGTPA----FACSQC---EAQFSSE---TALKQHALRRHPE 1511

  Fly   116 LAQILAVTELLNLYQLQPL-GEAKEATEIPAP----GEAQPNP----------DPEKKAEAVFEN 165
            .|              ||. |...|.||.|..    |...|:|          .|..:..|..|.
Human  1512 PA--------------QPAPGSPAETTEGPLHCSRCGLLCPSPASLRGHTRKQHPRLECGACQEA 1562

  Fly   166 RQSYFKLKNPRAVKSSSKVNYCIGCDFKCYQVQKMIEHM-----------------GSCEPSHLI 213
            ..|...|...|..:..|  :.|..|||...:...:::|.                 |......|.
Human  1563 FPSRLALDEHRRQQHFS--HRCQLCDFAARERVGLVKHYLEQHEETSAAVAASDGDGDAGQPPLH 1625

  Fly   214 CSLCEVGFLDWREYDTHLRRHSGDLRKPFFCLQCGIRFNTRAALLVHQPKHSTETP---HICPH- 274
            |..|:.........|.|::.|.|  .:.:.|..|......|..:..|...|:.|.|   |:||:
Human  1626 CPFCDFTCRHQLVLDHHVKGHGG--TRLYKCTDCAYSTKNRQKITWHSRIHTGEKPYHCHLCPYA 1688

  Fly   275 CGKGFKWKQGLSNHILVHNPEKQMLCDVCGYSTTHMKALKSHKLLHTG-EFFACTVSGCKHRANR 338
            |....:    |..|:.:|..|::.||..|||....:..||.|...||| :.:.|  ..|::..||
Human  1689 CADPSR----LKYHMRIHKEERKYLCPECGYKCKWVNQLKYHMTKHTGLKPYQC--PECEYCTNR 1747

  Fly   339 KENLKLHIET-HKQGRDFICEVCGCKF-------------SQSK---------------NLKRHA 374
            .:.|::|.|| |::.|.|:||.||..|             |::|               .|:.||
Human  1748 ADALRVHQETRHREARAFMCEQCGKAFKTRFLLRTHLRKHSEAKPYVCNVCHRAFRWAAGLRHHA 1812

  Fly   375 LKHTENGPNRYKCQLCGFSSHRSDKMKEHVQRVHTEKPVQLELSETV--DSSFP----DDFEL-- 431
            |.||:..|  :.|:||.:.:.:..::.:||:|.|   |.|.:.::.|  |.:.|    .|.:|
Human  1813 LTHTDRHP--FFCRLCNYKAKQKFQVVKHVRRHH---PDQADPNQGVGKDPTTPTVHLHDVQLED 1872

  Fly   432 --PVIETSPKKKPK 443
              |....:|...|:
Human  1873 PSPPAPAAPHTGPE 1886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	63/260 (24%)
		C2H2 Zn finger	214..234	CDD:275368	4/19 (21%)
		C2H2 Zn finger	244..264	CDD:275368	4/19 (21%)
		C2H2 Zn finger	272..292	CDD:275368	5/20 (25%)
		C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..349	CDD:275368	7/19 (37%)
		C2H2 Zn finger	357..377	CDD:275368	11/47 (23%)
		C2H2 Zn finger	387..408	CDD:275368	6/20 (30%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368
		C2H2 Zn finger	393..413	CDD:275368
		C2H2 Zn finger	421..438	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	545..566	CDD:275368
		C2H2 Zn finger	574..595	CDD:275368
		zf-H2C2_5	601..625	CDD:404746
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
		C2H2 Zn finger	714..731	CDD:275368
		PHA03247	928..>1219	CDD:223021
		C2H2 Zn finger	1306..1353	CDD:275368
		C2H2 Zn finger	1373..1394	CDD:275368
		C2H2 Zn finger	1402..1422	CDD:275368
		C2H2 Zn finger	1430..1451	CDD:275368
		C2H2 Zn finger	1626..1646	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1654..1674	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1682..1702	CDD:275368	6/23 (26%)
		C2H2 Zn finger	1710..1730	CDD:275368	7/19 (37%)
		zf-H2C2_2	1723..1747	CDD:404364	8/25 (32%)
		C2H2 Zn finger	1738..1759	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1767..1787	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1795..1815	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1823..1843	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100