DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plzf and ZNF131

DIOPT Version :9

Sequence 1:NP_001285862.1 Gene:Plzf / 34622 FlyBaseID:FBgn0032401 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_001284477.1 Gene:ZNF131 / 7690 HGNCID:12915 Length:623 Species:Homo sapiens


Alignment Length:540 Identity:129/540 - (23%)
Similarity:196/540 - (36%) Gaps:131/540 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QTMQSIPTLHQPLHSK-VSNYLNNQRRTGQFCDLLLELDSDDSLSLSVHFCVLAAQSQFINSNQK 68
            :||:.:...  |.|.| :.:.||.||...:|.|:.|.:|..   ....|..||||.|:|.  .:.
Human     5 ETMECLQEF--PEHHKMILDRLNEQREQDRFTDITLIVDGH---HFKAHKAVLAACSKFF--YKF 62

  Fly    69 QQQFSIHNPLKITIRNFSCTQCLHTIVDFFYEDLVSVSKEHELH-------FRELAQILAVTELL 126
            .|:|: ..|| :.|...|.....| :::|.|...:.:..|.|.:       |.::.:.:...|:.
Human    63 FQEFT-QEPL-VEIEGVSKMAFRH-LIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKALEVR 124

  Fly   127 NLYQLQPL-------GEAKE---------ATEIPAPGEAQPNPDPEKKAEAVFE-NRQSYFKLKN 174
            |.....||       .|||:         .||.....|::|.....:.||...| ..:....|:.
Human   125 NKENSAPLEENTTGKNEAKKRKIAETSNVITESLPSAESEPVEIEVEIAEGTIEVEDEGIETLEE 189

  Fly   175 PRAVKSSSKVNYCIGCDFKCYQVQKMIEHMGSCEPSHLICSLCEVGFLDWREYD----------- 228
            ..:.|.|                .|.|:..||.:.|.| ..|.:: ...:|:.|           
Human   190 VASAKQS----------------VKYIQSTGSSDDSAL-ALLADI-TSKYRQGDRKGQIKEDGCP 236

  Fly   229 -------------THLR-RHSGDLRKPFFCLQCGIRFNTRAALLVHQPKHSTETPHICPHCGKGF 279
                         ..|: .|..||   |.|.:|...|........|...||||: ..|..|.|.:
Human   237 SDPTSKQVEGIEIVELQLSHVKDL---FHCEKCNRSFKLFYHFKEHMKSHSTES-FKCEICNKRY 297

  Fly   280 ----KWKQGLSNHILVHN--PEKQM------LCDVCGYSTTHMKALKSHKLLHTGEF-FACTVSG 331
                .|||.|:.:.|...  .:||.      :|..|.....|....|.|...||||. |.|  ..
Human   298 LRESAWKQHLNCYHLEEGGVSKKQRTGKKIHVCQYCEKQFDHFGHFKEHLRKHTGEKPFEC--PN 360

  Fly   332 CKHRANRKENLKLHIET------HKQGRD--FICEVCGCKFSQSKNLKRHALKHTENGPNRYKCQ 388
            |..|..|...||.|:..      .|:||.  :.|:||...|:.....|.|.:.||.:.||.  |.
Human   361 CHERFARNSTLKCHLTACQTGVGAKKGRKKLYECQVCNSVFNSWDQFKDHLVIHTGDKPNH--CT 423

  Fly   389 LCGFSSHRSDKMKEHVQRVH-------TEKPVQLE--------LSETVDSSFPDDFELPVIETSP 438
            ||.....:.::::.|:...|       ||:.:.:|        .|.|:.........||:::.  
Human   424 LCDLWFMQGNELRRHLSDAHNISERLVTEEVLSVETRVQTEPVTSMTIIEQVGKVHVLPLLQV-- 486

  Fly   439 KKKPKSVKSK--TIRNVNPD 456
                 .|.|.  |:..|:||
Human   487 -----QVDSAQVTVEQVHPD 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlzfNP_001285862.1 COG5048 <193..403 CDD:227381 65/255 (25%)
C2H2 Zn finger 214..234 CDD:275368 4/44 (9%)
C2H2 Zn finger 244..264 CDD:275368 4/19 (21%)
C2H2 Zn finger 272..292 CDD:275368 8/23 (35%)
C2H2 Zn finger 300..320 CDD:275368 5/19 (26%)
C2H2 Zn finger 330..349 CDD:275368 6/24 (25%)
C2H2 Zn finger 357..377 CDD:275368 6/19 (32%)
C2H2 Zn finger 387..408 CDD:275368 4/20 (20%)
ZNF131NP_001284477.1 BTB 24..122 CDD:279045 27/105 (26%)
BTB 35..122 CDD:197585 22/94 (23%)
Nuclear localization signal 1. /evidence=ECO:0000269|PubMed:17306895 137..148 3/10 (30%)
COG5048 <262..444 CDD:227381 52/186 (28%)
C2H2 Zn finger 263..283 CDD:275368 4/19 (21%)
C2H2 Zn finger 290..311 CDD:275368 7/20 (35%)
Nuclear localization signal 2. /evidence=ECO:0000269|PubMed:17306895 317..328 2/10 (20%)
C2H2 Zn finger 330..350 CDD:275368 5/19 (26%)
zf-H2C2_2 342..367 CDD:290200 10/26 (38%)
C2H2 Zn finger 358..375 CDD:275368 6/18 (33%)
C2H2 Zn finger 394..414 CDD:275368 6/19 (32%)
C2H2 Zn finger 422..439 CDD:275370 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 573..623
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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