DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and MYNN

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001172047.1	Gene:	MYNN / 55892	HGNCID:	14955	Length:	610	Species:	Homo sapiens

Alignment Length:	519	Identity:	123/519 - (23%)
Similarity:	194/519 - (37%)	Gaps:	121/519 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MQSIPTLHQPLHSKVSNYLNNQRRTGQFCDLLLELD---------SDDSLSLSVHFCVLAAQS-- 60
            |:....:..|..:::|:...|.....|.|.|.|. |         |.|.:..:.....||.:|
Human   115 MEDFAFIANPSSTEISSITGNIELNQQTCLLTLR-DYNNREKSEVSTDLIQANPKQGALAKKSSQ 178

  Fly    61 -----QFINSNQKQQQFSIHNPLKI----TIRNFSCTQCLHTIVDFFYEDLVSVSKEHELHFREL 116
                 :..||.:..|..::..|..|    ::..|.....|.|.|   .|.:..::...||
Human   179 TKKKKKAFNSPKTGQNKTVQYPSDILENASVELFLDANKLPTPV---VEQVAQINDNSEL----- 235

  Fly   117 AQILAVTELLNLYQLQPLGEAKEATEIPAPGEAQPNPDPEKKAEAVFENRQSYFKLKN------P 175
             ::.:|.|  |.:..|.:  ....|.....|::|||...::.:.:...:.:|.::.:|      .
Human   236 -ELTSVVE--NTFPAQDI--VHTVTVKRKRGKSQPNCALKEHSMSNIASVKSPYEAENSGEELDQ 295

  Fly   176 RAVKSSSKVNYCIGCDFKCYQVQKMIEHM---GSCEPSHLICSLCEVGFLDWREYDTHLRRHSGD 237
            |..|:....|.| |..|.  :...:..||   ...:|  .:|.||...|....:..||:|.|:|:
Human   296 RYSKAKPMCNTC-GKVFS--EASSLRRHMRIHKGVKP--YVCHLCGKAFTQCNQLKTHVRTHTGE 355

  Fly   238 L---------------------------RKPFFCLQCGIRFNTRAALLVHQPKHSTETPHICPHC 275
            .                           .||:.|..|.::|.|.:.|.:|..|||.|.|::|..|
Human   356 KPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRC 420

  Fly   276 GKGFKWKQGLSNHILVHNPEKQMLCDVCGYSTTHMKALKSHKLLHTGEFFACTVSGCKHRANRKE 340
            |:.|.....|:.|:..|..||..:||.||.:.....:|.:|...||||
Human   421 GQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGE----------------- 468

  Fly   341 NLKLHIETHKQGRDFICEVCGCKFSQSKNLKRHALKHTENGPNRYKCQLCGFSSHRSDKMKEHVQ 405
                        :.:||.:||..|..|..|.:|...||  |...:.|:|||.|......:|:|..
Human   469 ------------KPYICGICGKSFISSGELNKHFRSHT--GERPFICELCGNSYTDIKNLKKHKT 519

  Fly   406 RVHTEKPVQLELSETVDSSFPDD--FELPVIETSPKKKPKSVKSKTIRNVNPDKRLKTLLPKET 467
            :||:      ...:|:|||..|.  .|...|:.||..:...||..       |..|...||..|
Human   520 KVHS------GADKTLDSSAEDHTLSEQDSIQKSPLSETMDVKPS-------DMTLPLALPLGT 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	61/239 (26%)
		C2H2 Zn finger	214..234	CDD:275368	7/19 (37%)
		C2H2 Zn finger	244..264	CDD:275368	6/19 (32%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..349	CDD:275368	0/18 (0%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	387..408	CDD:275368	7/20 (35%)
MYNN	NP_001172047.1	BTB	14..115	CDD:306997	123/519 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..197		6/27 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		3/15 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		0/4 (0%)
		C2H2 Zn finger	304..324	CDD:275368	6/22 (27%)
		zf-C2H2	304..324	CDD:306579	6/22 (27%)
		zf-H2C2_2	316..341	CDD:316026	7/26 (27%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..369	CDD:316026	5/23 (22%)
		SFP1	<354..438	CDD:227516	20/83 (24%)
		C2H2 Zn finger	360..380	CDD:275368	0/19 (0%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..437	CDD:275368	6/19 (32%)
		zf-H2C2_2	430..453	CDD:316026	9/22 (41%)
		SFP1	<439..522	CDD:227516	30/113 (27%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		C2H2 Zn finger	501..522	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..556		11/40 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960