DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and Sry-delta

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	99/457 - (21%)
Similarity:	155/457 - (33%)	Gaps:	156/457 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FC---DLLLELDSDDSLSLSVHFCVLAAQSQFINSNQK-------------QQQFSIHNPLKITI 82
            ||   ||     ||...|.|:.:..|:|:   :.|:||             |.|..:....::
  Fly     6 FCGAVDL-----SDTGSSSSMRYETLSAK---VPSSQKTVSLVLTHLANCIQTQLDLKPGARL-- 60

  Fly    83 RNFSCTQCLHTIVDFFYEDLVSVSKEHELHFRELAQILAVTELLNLYQLQPLGEAKEATEIPAPG 147
                |.:|...:.|:   |.:.|:             |..|:.....||:  |..|...|:|..|
  Fly    61 ----CPRCFQELSDY---DTIMVN-------------LMTTQKRLTTQLK--GALKSEFEVPESG 103

  Fly   148 E-----------AQPNPDPEKKAEAVF-----ENRQSYFKLK----------------------- 173
            |           :....|.:.:|:|:|     :..:|..::|
  Fly   104 EDILVEEVEIPQSDVETDADAEADALFVELVKDQEESDTEIKREFVDEEEEEDDDDDDEFICEDV 168

  Fly   174 ---------------NPRAVKSSSKVNYCIGCD---FKCYQVQKMIEHMGSCEPSHLICSLCEVG 220
                           ..|..|...| ..|..|.   ...||:||.|....|.:|:| ||.:|.|.
  Fly   169 DVGDSEALYGKSSDGEDRPTKKRVK-QECTTCGKVYNSWYQLQKHISEEHSKQPNH-ICPICGVI 231

  Fly   221 FLDWREYDTHLRRHSGDL--------------------------RKPFFCLQCGIRFNTRAALLV 259
            ..|....:.|:..|.|..                          :|.:.|.:||:||:....|..
  Fly   232 RRDEEYLELHMNLHEGKTEKQCRYCPKSFSRPVNTLRHMRMHWDKKKYQCEKCGLRFSQDNLLYN 296

  Fly   260 HQPKH-STETPHICPHCGKGFKWKQGLSNHILVHNPEK-QMLCDVCGYSTTHMKALKSHKLLHTG 322
            |:.:| :.|.|.||..|...||.::..::|.|:|...: :..|.||..|.|....||.|...|.|
  Fly   297 HRLRHEAEENPIICSICNVSFKSRKTFNHHTLIHKENRPRHYCSVCPKSFTERYTLKMHMKTHEG 361

  Fly   323 EFFACTVSGCKHRANRKENL---KLHIET-------------HKQGRDFICEVCGCKFSQSKNLK 371
            :    .|.|.:..|...|..   :||::.             :.:...| |.:|...|...|.|:
  Fly   362 D----VVYGVREEAPADEQQVVEELHVDVDESEAAVTVIMSDNDENSGF-CLICNTNFENKKELE 421

  Fly   372 RH 373
            .|
  Fly   422 HH 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	58/225 (26%)
		C2H2 Zn finger	214..234	CDD:275368	5/19 (26%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	330..349	CDD:275368	5/34 (15%)
		C2H2 Zn finger	357..377	CDD:275368	6/17 (35%)
		C2H2 Zn finger	387..408	CDD:275368
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	43/155 (28%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		C2H2 Zn finger	253..273	CDD:275368	0/19 (0%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..327	CDD:275370	4/16 (25%)
		zf-C2H2	337..359	CDD:278523	8/21 (38%)
		C2H2 Zn finger	339..359	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100