DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and CG31365

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	363	Identity:	83/363 - (22%)
Similarity:	128/363 - (35%)	Gaps:	94/363 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LNNQRRTGQFCDLLLELDSDDSLSLSVHFCVLAAQSQFINSNQKQQ---QFSIHNPLKI---TIR 83
            :|:.....|..|...|.|.|:.::               :.|.|:.   |||...|.:|   .:.
  Fly   334 INSASSEDQNQDSTPEFDQDNGIT---------------SYNIKEDGEIQFSGEKPEEIEDVVVF 383

  Fly    84 NFSCTQCLHTIVDFFYEDLVSVSKEHELHFRELAQILAVTELLNLYQLQPLGEAKEATEIPAPGE 148
            |..........|..|:|:::.|.||.                         .:..|.|.:..
  Fly   384 NLGEEISQEQQVFSFHENVIIVEKEQ-------------------------NDRDEQTPLKR--- 420

  Fly   149 AQPNPDPEKKAEAVFENRQSYFKLKNPR---AVKSSSKVNYCIGCDFKC------YQVQKM---- 200
                   ::.:|.||:...|..:.|..|   .|||           |:|      :..||:
  Fly   421 -------KRSSELVFKQESSCPQPKTGRITDTVKS-----------FQCHLCPVAFPTQKLLTRH 467

  Fly   201 ----IEHMGSCEPSHLICSLCEVGFLDWREYDTHLRRHSGDLRKPFFCLQCGIRFNTRAALLVHQ 261
                |:.:.|.:...|.|..|.:..........|:..|:|  .|||.|.:|.:.|:.|..|..|.
  Fly   468 HNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTG--LKPFKCSECELSFSQREVLKRHM 530

  Fly   262 PKHSTETPHICPHCGKGFKWKQGLSNHI-LVH-NPEKQMLCDVCGYSTTHMKALKSHKLLHTGEF 324
            ..|:....|.||.|...|..|..|..|| .|| ...:...|.:|..|..|:..|..|.:.|.|..
  Fly   531 DTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM 595

  Fly   325 FACTVSGCKHRANRKENLKLHIET-HK---QGRDFICE 358
            |:|  ..|..:.|.:..::.|:.| ||   :..|:|.|
  Fly   596 FSC--KQCGRQFNDRSAVQRHVTTMHKVKNKLTDYISE 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	51/186 (27%)
		C2H2 Zn finger	214..234	CDD:275368	3/19 (16%)
		C2H2 Zn finger	244..264	CDD:275368	6/19 (32%)
		C2H2 Zn finger	272..292	CDD:275368	8/20 (40%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..349	CDD:275368	4/19 (21%)
		C2H2 Zn finger	357..377	CDD:275368	1/2 (50%)
		C2H2 Zn finger	387..408	CDD:275368
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907
		RRF	<161..222	CDD:294170
		zf-C2H2_8	454..530	CDD:292531	18/77 (23%)
		C2H2 Zn finger	485..505	CDD:275368	3/19 (16%)
		zf-H2C2_2	497..522	CDD:290200	9/26 (35%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930