DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and CG14710

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster

Alignment Length:	323	Identity:	77/323 - (23%)
Similarity:	131/323 - (40%)	Gaps:	53/323 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LHQPLHSKVSNYLNNQRRTGQFCDLLLELDSDDSLSLSVHFCVLAAQSQFIN-SNQKQQQFSIHN 76
            |::.||.|:..  .||.:     :.:..::..|.........||......|| |.::.::.:..:
  Fly   104 LYENLHLKLGT--ENQEK-----EEITAIEEGDEQQEDQSQEVLDFNGFIINESIEEDEEPNTES 161

  Fly    77 PLKITIRNFSCTQCLHTIVDFFYEDLVSVSKEHELHFRELAQIL-----AVTELLN---LYQLQP 133
            |.:|.|.:          :|.:.:|            :::.:::     .|.||.|   .|:::.
  Fly   162 PEQILISH----------MDSYVDD------------QQMEELIDDKGELVEELSNANTFYEVEY 204

  Fly   134 LGEAKEATEIPAP------GEAQPNPDPEKKAEAVFENRQSYFKLK-NPRAVKSSSKVNYCIGCD 191
            ..|....:..|:|      .:.:|....:..||..|:.:....|.: |....|...|. .||.|.
  Fly   205 GDEELLMSSAPSPHPSFKMDKQKPGRPRKPDAELKFKRKDINAKERGNQPKCKEEEKF-MCILCG 268

  Fly   192 FKCYQVQKMIEHM---GSCEPSHLICSLCEVGFLDWREYDTHLRRHSGDLRKPFFCLQCGIRFNT 253
            ...|:......||   ...:|..  |.:|...|....|...|:|||:||  :|:.|:.|...|..
  Fly   269 NVFYKKSVFTAHMMTHSEYKPHQ--CEICNKSFRQMGELRAHIRRHTGD--RPYKCMYCDRHFYD 329

  Fly   254 RAALLVHQPKHSTETPHICPHCGKGFKWKQGLSNHILVHNPEKQMLCDVCGYSTTHMKALKSH 316
            |:..:.|:..|:...|:.|..|||.|.....|.||||.|:.:|...|.:|..|.|.:..||:|
  Fly   330 RSERVRHERVHTNTRPYACQECGKTFTHTAILKNHILSHSAQKNYNCGICCKSFTLLHQLKAH 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	41/127 (32%)
		C2H2 Zn finger	214..234	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	5/19 (26%)
		C2H2 Zn finger	272..292	CDD:275368	10/19 (53%)
		C2H2 Zn finger	300..320	CDD:275368	7/17 (41%)
		C2H2 Zn finger	330..349	CDD:275368
		C2H2 Zn finger	357..377	CDD:275368
		C2H2 Zn finger	387..408	CDD:275368
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071
		COG5048	<261..395	CDD:227381	45/137 (33%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-C2H2	290..312	CDD:278523	6/23 (26%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		zf-H2C2_2	304..327	CDD:290200	10/24 (42%)
		C2H2 Zn finger	320..340	CDD:275368	5/19 (26%)
		zf-H2C2_2	335..357	CDD:290200	8/21 (38%)
		C2H2 Zn finger	348..368	CDD:275368	10/19 (53%)
		C2H2 Zn finger	376..395	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453403
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930