DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and Neu2

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	407	Identity:	93/407 - (22%)
Similarity:	128/407 - (31%)	Gaps:	122/407 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 QFSIHNPLKITIRNFSCTQCLHTIVDFFYEDLVSVSKEHELHFRELAQILAVTELLNLYQLQPLG 135
            |...|:||..||    |..||....:.|  |::...:.....:|.|..:
  Fly    26 QVEKHDPLSNTI----CKSCLEDAQNAF--DIIETYERSHQFYRFLKDV---------------- 68

  Fly   136 EAKEATEIPAPGEAQPNPDPEKKAEAVFENRQSYFKLKNPRAVKSSSK--VNYCIGCDFKCYQVQ 198
             .:|.:|....|.::       :.||...:.|.     ....|.|.::  :|   .||.|
  Fly    69 -REEESENDGSGCSE-------EVEAAERDLQD-----GADDVDSGNEPDIN---ECDIK----- 112

  Fly   199 KMIEHMGSCEPSHLICSLCEVGFLDWREYDTHLRRHSGDLRKPFFCLQCGIRFNTRAALLVHQPK 263
                   :.|.....||.|...|........|:|.|:|:  :||.|..|...|...:.|..|...
  Fly   113 -------AKEKPGFSCSHCPKSFQVKSNLKVHMRSHTGE--RPFTCSLCPKSFGYSSGLQNHMRT 168

  Fly   264 HSTETPHICPHCGKGFKWKQGLSNHILVHNPEKQMLCDVCGYSTTHMKALKSHKLLHTGEF-FAC 327
            |:.|.|..|.||.:.|.....|..||.:|.....:.|..|.........||.|...||.|. |.|
  Fly   169 HTGERPFQCSHCPRSFTAGHHLKAHIQMHERRGSLRCPYCQKCFLTSLILKQHLATHTDETQFKC 233

  Fly   328 TVSGCKHRANRKENLKLHIETHKQGRDFICEVCGCKFSQSKNLKRH------------------- 373
              |.|......:..|.:|:..| |.|.|.|..|...|:....||||
  Fly   234 --SQCSKSFQVEHELWMHMRVH-QERLFTCGHCSKDFALHAYLKRHLSRNARCSQSSKASAHKTL 295

  Fly   374 ----ALK--------------------HTENGP--------------------NRYKCQLCGFSS 394
                |||                    ||:|.|                    ..:||..|..:.
  Fly   296 GHSKALKCGKCPKTFTDRSALSTHLKSHTKNKPLLEGPCKSSGSKPAHSNAQRKPFKCSSCPRTF 360

  Fly   395 HRSDKMKEHVQRVHTEK 411
            .|...:..|:| .||.|
  Fly   361 SRKSALLTHLQ-THTGK 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	64/273 (23%)
		C2H2 Zn finger	214..234	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	5/19 (26%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..349	CDD:275368	4/18 (22%)
		C2H2 Zn finger	357..377	CDD:275368	10/62 (16%)
		C2H2 Zn finger	387..408	CDD:275368	5/20 (25%)
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	11/42 (26%)
		COG5048	<119..241	CDD:227381	38/125 (30%)
		C2H2 Zn finger	121..141	CDD:275368	6/19 (32%)
		zf-H2C2_2	133..158	CDD:290200	9/26 (35%)
		C2H2 Zn finger	149..169	CDD:275368	5/19 (26%)
		zf-H2C2_2	162..185	CDD:290200	8/22 (36%)
		C2H2 Zn finger	177..197	CDD:275368	7/19 (37%)
		C2H2 Zn finger	205..225	CDD:275368	5/19 (26%)
		zf-C2H2_8	206..286	CDD:292531	24/82 (29%)
		C2H2 Zn finger	233..253	CDD:275368	5/21 (24%)
		C2H2 Zn finger	260..297	CDD:275368	7/36 (19%)
		C2H2 Zn finger	303..323	CDD:275368	0/19 (0%)
		C2H2 Zn finger	353..373	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030