DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and pita

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	89/408 - (21%)
Similarity:	154/408 - (37%)	Gaps:	72/408 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NNQRRTGQFCDLLLELDSDDSLSLSVHFCVLAAQSQFINSNQKQQQFSIHNPLKITIRNFSCTQC 90
            |||           ||..||..|: :.......:.:|.:..||.      :|:|..:.|.|..:.
  Fly   183 NNQ-----------ELSMDDVQSM-LEDMASELEKEFPDIPQKA------SPVKPKVLNKSSIRI 229

  Fly    91 LHTIVDFFYEDLVSVSKEHELHFRELAQILAVTELLNLYQLQPLGEAKEATEIPAPGEAQPNPDP 155
            |:.......|..::..|   :...:...:..|||:|:             :::|...:..|..:.
  Fly   230 LNKGPAAPVEPRLATPK---VKRDDSGNVAIVTEVLD-------------SDLPLDDQDDPTKNA 278

  Fly   156 EKKAEAVFENRQSYFKLKNPRAVKSSSKVNYCIGCDFKCYQVQKMIE--HMGSCEPSHLICSLCE 218
            ||.|..||.                      |..|: :.:.:|:::|  .:.........|.|||
  Fly   279 EKVATDVFP----------------------CPDCE-RSFPLQQLLEIHRLNHTRSRSFQCLLCE 320

  Fly   219 VGFLDWREYDTHLRRHSGDLRKPFFCLQCGIRFNTRAALLVHQPKHSTETPHICPHCGKGFKWKQ 283
            ..|....:...|...|:|:  :||.|..|...|..:|.|..|:..|:.....||.:|.|.|..:|
  Fly   321 KSFFSKYDLAKHNFVHTGE--RPFKCAICSKAFTRKALLHRHERTHTDVPKFICVYCEKPFLSRQ 383

  Fly   284 GLSNHILVHNPEKQMLCDVCGYSTTHMKALKSHKLLHTGEF-FACTVSGCKHRANRKENLKLHIE 347
            .:..|...|..::...|.||..|....:.|:.|:.:|:... |.|  ..|:...:....|..|:.
  Fly   384 EMEKHAERHQKKRPFQCGVCTKSFAFKQGLERHETVHSTNLPFPC--QHCERSFSTASKLARHLV 446

  Fly   348 THKQGRDFICEVCGCKFSQSKNLKRHALKHTENGPNRYKCQLCGFSSHRSDKMKEHVQRVHTEKP 412
            .|...|.:.|:.|...:..|.:|.||...||:.....:.|..|..|....:.:.:|. .:|....
  Fly   447 AHAGKRAYPCKYCHKSYMLSHHLSRHLRTHTQTSDASFVCSECKVSYSNYNDLLDHA-LIHATAS 510

  Fly   413 V-------QLELSETVDS 423
            :       |:|..::|:|
  Fly   511 LKCPMCRKQIEDIDSVES 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	52/212 (25%)
		C2H2 Zn finger	214..234	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	6/19 (32%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..349	CDD:275368	3/18 (17%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	387..408	CDD:275368	4/20 (20%)
pita	NP_611806.3	zf-AD	17..92	CDD:214871
		COG5048	<281..506	CDD:227381	58/252 (23%)
		C2H2 Zn finger	288..308	CDD:275368	4/20 (20%)
		C2H2 Zn finger	316..336	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..353	CDD:290200	8/26 (31%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		C2H2 Zn finger	372..388	CDD:275370	5/15 (33%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	428..448	CDD:275368	4/21 (19%)
		C2H2 Zn finger	456..476	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..506	CDD:275368	4/20 (20%)
		HARE-HTH	<566..625	CDD:294801
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446664
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930