DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and CG1529

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001138223.2	Gene:	CG1529 / 33077	FlyBaseID:	FBgn0031144	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	81/368 - (22%)
Similarity:	146/368 - (39%)	Gaps:	81/368 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 CTQCLHTIVDFFYEDLVSVSKEHELHFRELAQILAVTELLNLYQLQPLGEA------------KE 139
            |..|.:.:|  ::::|..|::|..   ::|.....|...::..:.:|..|.            :|
  Fly    55 CNLCHNAVV--YFDELRQVARESS---QKLIGWQPVDIAVDRVKEEPPDEGLKENHEENEHELEE 114

  Fly   140 ATEIPAPGEAQPNPDPEKKAE---AVFENRQ------SYFKLKNPRAVKSSSKVNYCIGCDFKCY 195
            ..|..|.|:   ..|..||.|   .:.::|:      .|...:...:..:.||....:.||....
  Fly   115 EHEKQADGQ---QVDLSKKQEDQKKILDDREDEEYPDEYENSQQQLSQGTGSKRRAGLACDQCGK 176

  Fly   196 QVQKM--IE------HMGSCEPSHLICSLCEVGFLDWREYDTHLRRHSGDLR------KPFFCLQ 246
            ||.|:  :|      |.|..:|  .:|..|:..|..:.:..:|:|.....|.      :...|..
  Fly   177 QVYKLPYLEAHIRSVHQGYSKP--FLCRSCDKSFTRYEQLRSHMRNAHPQLEQLQQELRDLICEL 239

  Fly   247 CGIRFNTRAALLVHQPKHSTETPHICPHCGKGFKWKQGLSNHILVHNPE-KQMLCDVCGYSTTHM 310
            |..:::|:.||..|..:|:....|:|.|||.....:..|..|:..|||. ::..|:.|.....|.
  Fly   240 CNRQYSTKNALGEHLKRHAQRKEHVCEHCGVAKVTRTELLTHLRTHNPTWERFKCEQCPQLFRHK 304

  Fly   311 KALKSH-KLLHTGE-FFACTVSGCKHR----ANRKENLKLHIETHKQGR-----DFIC----EVC 360
            .|:..| :::|.|: .|.|  ..|:.:    |::..:.:||.|:...|.     .|.|    :.|
  Fly   305 SAISRHVRVVHEGQRRFQC--GHCEKKFGTHASQVRHERLHTESTGSGEAAEEWPFACIHCQKPC 367

  Fly   361 GCKFSQSKNLKRHALKHTENGPNRYKCQLCGFSSHRSDKMKEH 403
            ..:.:...:|:||..:.|                ||  |.:||
  Fly   368 VSRQTLELHLRRHRARKT----------------HR--KRREH 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	55/239 (23%)
		C2H2 Zn finger	214..234	CDD:275368	5/19 (26%)
		C2H2 Zn finger	244..264	CDD:275368	6/19 (32%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	5/20 (25%)
		C2H2 Zn finger	330..349	CDD:275368	5/22 (23%)
		C2H2 Zn finger	357..377	CDD:275368	5/23 (22%)
		C2H2 Zn finger	387..408	CDD:275368	5/17 (29%)
CG1529	NP_001138223.2	zf-AD	11..79	CDD:285071	6/28 (21%)
		C2H2 Zn finger	171..192	CDD:275368	6/20 (30%)
		zf-C2H2_2	201..>257	CDD:289522	12/55 (22%)
		C2H2 Zn finger	201..222	CDD:275368	5/20 (25%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		C2H2 Zn finger	265..285	CDD:275368	6/19 (32%)
		zf-C2H2_8	268..349	CDD:292531	21/82 (26%)
		C2H2 Zn finger	294..315	CDD:275368	5/20 (25%)
		C2H2 Zn finger	323..343	CDD:275368	3/21 (14%)
		C2H2 Zn finger	360..380	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100