DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and CG43347

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001138185.2	Gene:	CG43347 / 31991	FlyBaseID:	FBgn0263072	Length:	2684	Species:	Drosophila melanogaster

Alignment Length:	454	Identity:	104/454 - (22%)
Similarity:	159/454 - (35%)	Gaps:	132/454 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 SVSKEHELHFRE--LAQILAVTELLNLYQLQPL-------GEAKEATEIPAPGEA---------- 149
            ||..|.|||..|  :..:.|.||:....:|.||       ||.:|.:::....|.
  Fly  1030 SVPAEFELHNVEPNVTGVFARTEVRAFTKLGPLIGQPVQTGEVREGSDMKWIFEMCEAGADKSYL 1094

  Fly   150 ----QPN---------PDP---EKKAEAVFENRQSYF----KLKNPRAV-------------KSS 181
                .||         |.|   |:....|..:||:||    .|:|...:             |.:
  Fly  1095 LCCDNPNASNWLRFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYWSDDCNTMWRKKHT 1159

  Fly   182 SKVNYCIGCDFKCYQVQKMIEHMGSCEPSHLICSLCEVGFLDWREYDTHLR-----RHSGDLRKP 241
            .|.| |.||:.|       .||     |.:               |.||..     ..|..:||
  Fly  1160 EKTN-CGGCNLK-------FEH-----PLY---------------YRTHCSVFHDPSMSLTIRK- 1195

  Fly   242 FFCLQCGIRFNTRAALLVH-QPKHSTETPHICPHCGKGFKWKQGLSNHILVH-------NPEK-Q 297
            :.|..||.....:..::.| ..||..:..:.|..|.|.|.    ..|::.:|       ||.: :
  Fly  1196 YHCKVCGEPVLGKDNIMKHAAEKHDGKGAYQCQFCSKFFL----RLNYLEMHRTYGCASNPNRSR 1256

  Fly   298 MLCDVCGYSTTHMKALKSH-KLLHTG-----EFFACTVSGCKHRANRKENLKLHI-ETHKQGRDF 355
            .:||.||......:.||:| |.:|:.     ..|.|.:  |......:..|:.|. |.|.:....
  Fly  1257 PVCDFCGRKFCQPQKLKAHIKRMHSDMAEVLRDFQCKL--CSKLLGSRAALQRHSKEVHSRNSTV 1319

  Fly   356 I-CEVCGCKFSQSKNLKRHALKHTENGPNRYKC--QLCGFSSHRSDKMKEHVQRVHT---EKPVQ 414
            : |..|...|....|||.|.|.|  :|...:||  ..|..:......::.|.::||.   |:..:
  Fly  1320 VSCPRCQKLFQNRSNLKIHMLTH--SGVRPFKCAEPECNAAFTTKQCLQFHYKKVHNYTQEQMPK 1382

  Fly   415 LELS-----ETVDSSFPDDF-------ELPVIETSPKKKPKS----VKSKTIRNVNPDKRLKTL 462
            :|.|     :........||       ..|....|.:.:|:.    |...:.....|.:|.|:|
  Fly  1383 IERSVAYTFDAYSGGMKVDFLGKQTATATPASAASAQAQPRPNAAVVSPSSFTEQAPRRRRKSL 1446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	53/233 (23%)
		C2H2 Zn finger	214..234	CDD:275368	3/24 (13%)
		C2H2 Zn finger	244..264	CDD:275368	4/20 (20%)
		C2H2 Zn finger	272..292	CDD:275368	5/19 (26%)
		C2H2 Zn finger	300..320	CDD:275368	8/20 (40%)
		C2H2 Zn finger	330..349	CDD:275368	4/19 (21%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		C2H2 Zn finger	387..408	CDD:275368	3/22 (14%)
CG43347	NP_001138185.2	NR_DBD_like	1198..>1268	CDD:295381	18/73 (25%)
		C2H2 Zn finger	1198..1219	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1227..1255	CDD:275368	8/31 (26%)
		C2H2 Zn finger	1259..1280	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1292..1313	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1322..1342	CDD:275368	8/19 (42%)
		zf-H2C2_2	1334..1361	CDD:290200	10/28 (36%)
		C2H2 Zn finger	1350..1373	CDD:275368	3/22 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100