DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and Zbtb38

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001012489.2	Gene:	Zbtb38 / 315936	RGDID:	1310136	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	83/375 - (22%)
Similarity:	137/375 - (36%)	Gaps:	99/375 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 YQLQ----------------PLG--------------EAKEATEIPAPGEAQPNPDPEKKAEAVF 163
            ||:|                |||              |..:......|.....|..|:||::.:.
  Rat   860 YQMQEETLPRESDPETRGDSPLGLCQADCVEMSEAFDEVSDQDSTDKPWRPYYNYKPKKKSKQLR 924

  Fly   164 ENRQSYFKLKNPRAVKS---------------SSKVNYCIGCDFKCYQVQ----KMIEHMGSCEP 209
            :.|:  .|.:..|..:|               ..:..|....| :|.:|:    |..|...:.|.
  Rat   925 KIRK--VKWRKERGSRSPVGRRRYPAELDRAEMGRRRYPAELD-RCAEVKLPPDKASEEEENKEM 986

  Fly   210 SHLICSLCE------VGFLDWREYDTHLRRHSGDLRKPFFCLQCGIRFNTRAALLVHQPKHSTET 268
            ..|.|.||:      .|        ...:.|.....||:.|..|..:|.:.:.|.:|...|:.|.
  Rat   987 PKLQCELCDGDKAAGAG--------AEGKPHQHLTLKPYICELCAKQFQSSSTLKMHMRCHTGEK 1043

  Fly   269 PHICPHCGKGFKWKQGLSNHILVHNPEKQMLCDVCGYSTTHMKALKSHKLLHTGE-FFAC--TVS 330
            |:.|..||:.|..:..|..|..:|...|:.:|..|..:.|..:.||.|:.:|||| .:.|  ...
  Rat  1044 PYQCKTCGRRFSVQGNLQKHERIHLGVKEFICQYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQ 1108

  Fly   331 GCKHRANRKENLKLHIETHKQGRDFICEVCG--CK------FSQSKNLKRHALKHTENGPNRYKC 387
            |..:.:.::.:.:.|:..| .|:.|.|..|.  ||      ..|.|:|.:...|..|..
  Rat  1109 GFLYLSTKRNHERRHVREH-DGKGFACFQCPKICKTAAALRMHQKKHLFKTLTKQEETD------ 1166

  Fly   388 QLCGFSSHRSDKMKEHVQRVHTEKPVQLELSETVDSSFPDDFELPVIETS 437
            .||    |.:..:.|       .:|    .:::.||...||.:.|:::.|
  Rat  1167 DLC----HENSDLLE-------SQP----CTDSEDSDQKDDIKKPLLKMS 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	57/230 (25%)
		C2H2 Zn finger	214..234	CDD:275368	4/25 (16%)
		C2H2 Zn finger	244..264	CDD:275368	5/19 (26%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..349	CDD:275368	2/18 (11%)
		C2H2 Zn finger	357..377	CDD:275368	7/27 (26%)
		C2H2 Zn finger	387..408	CDD:275368	4/20 (20%)
Zbtb38	NP_001012489.2	BTB_POZ_ZBTB38_CIBZ	15..128	CDD:349532
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..334
		Interaction with CBFA2T3. /evidence=ECO:0000250\|UniProtKB:Q8NAP3	299..522
		zf-C2H2_8	308..401	CDD:406359
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	372..391	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	517..535	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..776
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..882		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..914		2/18 (11%)
		C2H2 Zn finger	1019..1039	CDD:275368	5/19 (26%)
		zf-H2C2_2	1032..1055	CDD:404364	8/22 (36%)
		zf-C2H2	1045..1067	CDD:395048	6/21 (29%)
		C2H2 Zn finger	1047..1067	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1075..1095	CDD:275368	6/19 (32%)
		zf-H2C2_2	1088..1112	CDD:404364	9/23 (39%)
		C2H2 Zn finger	1103..1123	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1134..1154	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1172..1203		8/41 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000