DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and Zbtb25

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_955790.1	Gene:	Zbtb25 / 314245	RGDID:	735076	Length:	438	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	106/496 - (21%)
Similarity:	166/496 - (33%)	Gaps:	166/496 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 HSKV-SNYLNNQRRTGQFCDLLLELDSDDSLSLSVHFCVLAAQSQF---INSNQKQQQFSIHNPL 78
            ||.| ...||.||..|..||..:.:   ..:....|..||||.|.:   |..:|..:...| .|.
  Rat     6 HSLVLLQQLNMQREFGFLCDCTVAI---GDVYFKAHRAVLAAFSNYFKMIFIHQTSECIKI-QPA 66

  Fly    79 KITIRNFSCTQCLH---------TIVD---------FFYEDLVSVSKEHELHF-RELAQILA--V 122
            .|....||  ..||         .|||         |.:.|.:|       |. .|:.|:.:  .
  Rat    67 DIQPDIFS--YLLHIMYTGKGPKQIVDHSRLEEGIRFLHADYLS-------HIATEMNQVFSPET 122

  Fly   123 TELLNLYQLQ-------PLGEAKEATEIP---------APGE-----------------AQPNPD 154
            .:..|||.:|       .:.:..|..:.|         |||:                 .|....
  Rat   123 VQTSNLYGIQISTTQKTAVKQGLEIKDTPPSSSGNRAAAPGDHPQLQLSLAIGLDDGGAEQQRAH 187

  Fly   155 PEKKAEAVFENRQSYFKLK----NPRAV------KSSSKVNYCIGCDFKCYQVQKMIEHMGSCEP 209
            |  .|:|:.|:::....:|    :|.:|      .|||:|.   |..|....|:
  Rat   188 P--AAQALEEHQKPPVTIKQERCDPESVISQSHSSSSSEVT---GSSFTENSVK----------- 236

  Fly   210 SHLICSLCEVGFLDWREYDTHLRRH-SGDLRKPFFCLQCGIRFNTRAALL-------VHQPKHST 266
            .|| |..|...|........||..| ||.|           .|...|::|       ||....|:
  Rat   237 VHL-CHYCGERFESRSNLRQHLHTHVSGSL-----------PFGVPASILESNDLGEVHPLSGSS 289

  Fly   267 ET-----------------PHICPHCGKGFKWKQGLSNHILVHNPEKQMLCDVCGYSTTHMKALK 314
            |.                 |....|.|:|......:|...::....:.:..: |.:|.:..:.:
  Rat   290 EALECRRLGSFLAEEDGQQPRPPEHSGRGPSEPLQISQVSVISKDTEPVELN-CNFSFSRKRKI- 352

  Fly   315 SHKLLHTGEFFACTVSGCKHRANRKENLKLHIETHKQGRDFICEVCGCKFSQSKNLKRHALKHTE 379
                       :||:  |.|:..||..|..|:.||| |:.:....|. :|..|  |.:...::.:
  Rat   353 -----------SCTI--CGHKFLRKSQLLEHMYTHK-GKSYRYNRCQ-RFGNS--LAQRFQQYCD 400

  Fly   380 NGPNRYKCQLCGFSSHRSDKMKEHVQRVHTEKPVQLELSET 420
            :.|:         .|.::.::.:.    |.:.|..||...|
  Rat   401 SWPD---------VSLKTSRLSQE----HLDLPCALESEMT 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	44/234 (19%)
		C2H2 Zn finger	214..234	CDD:275368	5/19 (26%)
		C2H2 Zn finger	244..264	CDD:275368	5/26 (19%)
		C2H2 Zn finger	272..292	CDD:275368	4/19 (21%)
		C2H2 Zn finger	300..320	CDD:275368	2/19 (11%)
		C2H2 Zn finger	330..349	CDD:275368	6/18 (33%)
		C2H2 Zn finger	357..377	CDD:275368	4/19 (21%)
		C2H2 Zn finger	387..408	CDD:275368	1/20 (5%)
Zbtb25	NP_955790.1	BTB_POZ_ZBTB25_ZNF46_KUP	3..130	CDD:349522	36/136 (26%)
		C2H2 Zn finger	238..260	CDD:275369	7/22 (32%)
		zf-C2H2	240..260	CDD:395048	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000