DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plzf and ZBTB48

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001265576.1	Gene:	ZBTB48 / 3104	HGNCID:	4930	Length:	688	Species:	Homo sapiens

Alignment Length:	644	Identity:	131/644 - (20%)
Similarity:	203/644 - (31%)	Gaps:	244/644 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 HS-KVSNYLNNQRRTGQFCDLLLELDSDDSLSLSVHFCVLAAQSQFINSNQKQ-QQFSIHNPLKI 80
            || :|...||.||..||:||..|::   ..|....|:.|||..|.|..|.... ...|:..|.
Human     8 HSVRVLQELNKQREKGQYCDATLDV---GGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPA-- 67

  Fly    81 TIRNFSCTQCLHTIVDFFYEDLVSVSKEHELHFRELAQILAVTELLNLYQ--------------- 130
                 ...:....::||||...::::..:.......|:.|.|.|.:.|.|
Human    68 -----GFAEIFGLLLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSFKPKTSVGQAAGGQ 127

  Fly   131 ---------------LQPLG-EAKEATEI-----------------------PAPGEA------- 149
                           .:|.| |.:|.:..                       ||..|.
Human   128 SGLGPPASQNVNSHVKEPAGLEEEEVSRTLGLVPRDQEPRGSHSPQRPQLHSPAQSEGPSSLCGK 192

  Fly   150 -----QPNPDPEKK------------------------------------------AEAVFENRQ 167
                 :|.|..:||                                          .|||...|:
Human   193 LKQALKPCPLEDKKPEDCKVPPRPLEAEGAQLQGGSNEWEVVVQVEDDGDGDYMSEPEAVLTRRK 257

  Fly   168 S----------------------------------------------YFKLKNPRAVKSSSKVNY 186
            |                                              |.|:.|.:  .:..|...
Human   258 SNVIRKPCAAEPALSAGSLAAEPAENRKGTAVPVECPTCHKKFLSKYYLKVHNRK--HTGEKPFE 320

  Fly   187 CIGCDFKCY-QVQKMIEHMG-SC---EPSHLICSLCEVGFLDWREYDTHLRRHSGDL-------- 238
            |..|. ||| :.:.::||.. :|   ......||:|:..|....|...|:..|:|::
Human   321 CPKCG-KCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCS 384

  Fly   239 ------------------------------------------------RKPFFCLQCGIRFNTRA 255
                                                            .|.|.|.:||.|.::|.
Human   385 QQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEKLFVCEECGHRASSRN 449

  Fly   256 ALLVH-QPKHSTETPHICPHCGKGFKWKQGLSNHILVHNPEKQMLCDVCGYSTTHMKALKSHKLL 319
            .|.:| :.||..|.||:|..|...|..|..|:.|:..|..||...|.:||.:.....:|..|...
Human   450 GLQMHIKAKHRNERPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASLDKHNRT 514

  Fly   320 HTGEF-FACTVSGCKHRANRKENLKLHIET-HKQGRDFICEVCGCKFSQSKNLKRHALKHTENGP 382
            ||||. |:|..  |:.|...|..|..|:.: |::||...|::||..|...:.|:.|..:|  .|.
Human   515 HTGERPFSCEF--CEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHVRRH--KGV 575

  Fly   383 NRYKCQLCGFSSHRSDKMKEHVQ---RVHTEKPVQLELSETVDSSFPDDFELPVIETSP 438
            .:::|..||:...|...::.|::   ||....|.|.:|...:    .:|.::.|:...|
Human   576 RKFECTECGYKFTRQAHLRRHMEIHDRVENYNPRQRKLRNLI----IEDEKMVVVALQP 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	68/273 (25%)
		C2H2 Zn finger	214..234	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	7/20 (35%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..349	CDD:275368	5/19 (26%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	387..408	CDD:275368	6/23 (26%)
ZBTB48	NP_001265576.1	BTB	16..119	CDD:306997	29/112 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..140		0/20 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..192		3/30 (10%)
		C2H2 Zn finger	293..313	CDD:275368	3/21 (14%)
		zf-H2C2_2	305..328	CDD:316026	7/25 (28%)
		C2H2 Zn finger	321..372	CDD:275368	14/51 (27%)
		SFP1	<374..459	CDD:227516	10/84 (12%)
		C2H2 Zn finger	380..401	CDD:275368	0/20 (0%)
		C2H2 Zn finger	409..425	CDD:275370	0/15 (0%)
		C2H2 Zn finger	438..459	CDD:275368	7/20 (35%)
		COG5048	<464..612	CDD:227381	47/151 (31%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		C2H2 Zn finger	495..515	CDD:275368	5/19 (26%)
		C2H2 Zn finger	523..540	CDD:275368	5/18 (28%)
		C2H2 Zn finger	555..572	CDD:275368	5/16 (31%)
		C2H2 Zn finger	580..600	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000