DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plzf and ZBTB11

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_055230.2	Gene:	ZBTB11 / 27107	HGNCID:	16740	Length:	1053	Species:	Homo sapiens

Alignment Length:	579	Identity:	119/579 - (20%)
Similarity:	203/579 - (35%)	Gaps:	193/579 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PLHSK-VSNYLNNQRRTGQFCDLLLELDSDDSLSLSVHFCVLAAQSQFINSNQKQQQFSIHNPLK 79
            |.|.: |...||.||.:.||||:.|.::.::   ...|..||:|.|::......::.....:...
Human   194 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEE---YKAHKSVLSANSEYFRDLFIEKGAVSSHEAV 255

  Fly    80 ITIRNFSCTQCLHTIVDFFYEDLVSVSKEHELHFRELAQILAVTELLNLYQ-LQPLGEAKEAT-- 141
            :.:..| |......:::|.|..::|...........||:.|.::|:|.:.: :..|.|.|:.|
Human   256 VDLSGF-CKASFLPLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVY 319

  Fly   142 --------------------------------------------------EIPAP---GEAQPNP 153
                                                              |:|..   ||....|
Human   320 KKGEVQTVASTQDLRVQNGGTAPPVASSEGTTTSLPTELGDCEIVLLVNGELPEAEQNGEVGRQP 384

  Fly   154 DPEKKAEA----------------------VFENRQSYFKLKNPRA---------------VKSS 181
            :|:..:||                      :.:|.|:..:..|.|.               |.||
Human   385 EPQVSSEAESALSSVGCIADSHPEMESVDLITKNNQTELETSNNRENNTVSNIHPKLSKENVISS 449

  Fly   182 SKVNYCIGCDFKCYQV---------QKMIEHMGSCEPSHLICSLCEVGF----------LDWREY 227
            |..:..:|.|.....:         ||:.:.:...|  :|:.|..:..|          |..|..
Human   450 SPEDSGMGNDISAEDICAEDIPKHRQKVDQPLKDQE--NLVASTAKTDFGPDDDTYRSRLRQRSV 512

  Fly   228 D--THLRRHSG----------------------------DLRKP------------FFCLQCGIR 250
            :  .::|.|.|                            .:::|            ..|.:||:.
Human   513 NEGAYIRLHKGMEKKLQKRKAVPKSAVQQVAQKLVQRGKKMKQPKRDAKENTEEASHKCGECGMV 577

  Fly   251 FNTRAALLVHQPKHSTETPHICPHCGKGFKWKQGLSNHILVH----------------------- 292
            |..|.||::|:.||.....:.||.|.|.|::...|..|::.|
Human   578 FQRRYALIMHKLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPSSSSSNSTSNEASGTSS 642

  Fly   293 ---NPEKQMLCDVCGYSTTHMKALKSHKLLHTG-EFFACTVSGCKHRANRKENLKLHIETHKQGR 353
               ..:::.:|.:||.:...:.:|:.|.|.||| :..||.|  |......|..||||...|:..:
Human   643 EKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQV--CGKTFIYKHGLKLHQSLHQSQK 705

  Fly   354 DFICEVCGCKFSQSKNLKRHALKHTENGPNRYKCQLCGFSSHRSDKMKEHVQRVHTEKP 412
            .|.||:|...|...::|:.|...||  |.::|.|.:||.|.||...:.:|.:: |..||
Human   706 QFQCELCVKSFVTKRSLQEHMSIHT--GESKYLCSVCGKSFHRGSGLSKHFKK-HQPKP 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	66/297 (22%)
		C2H2 Zn finger	214..234	CDD:275368	5/31 (16%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..349	CDD:275368	6/18 (33%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	387..408	CDD:275368	7/20 (35%)
ZBTB11	NP_055230.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..173
		BTB	204..305	CDD:279045	24/104 (23%)
		BTB	215..306	CDD:197585	17/94 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..566		1/19 (5%)
		C2H2 Zn finger	571..591	CDD:275368	8/19 (42%)
		C2H2 Zn finger	599..619	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..643		1/23 (4%)
		C2H2 Zn finger	653..673	CDD:275368	6/19 (32%)
		zf-H2C2_2	665..690	CDD:290200	10/26 (38%)
		C2H2 Zn finger	681..701	CDD:275368	8/21 (38%)
		C2H2 Zn finger	709..729	CDD:275368	6/19 (32%)
		zf-H2C2_2	721..746	CDD:290200	10/26 (38%)
		C2H2 Zn finger	737..757	CDD:275368	7/20 (35%)
		C2H2 Zn finger	768..788	CDD:275368
		zf-H2C2_2	780..804	CDD:290200
		C2H2 Zn finger	796..816	CDD:275368
		C2H2 Zn finger	860..880	CDD:275368
		C2H2 Zn finger	888..908	CDD:275368
		zf-H2C2_2	900..923	CDD:290200
		C2H2 Zn finger	916..937	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000