DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plzf and Zbtb24

DIOPT Version :9

Sequence 1:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_700447.2	Gene:	Zbtb24 / 268294	MGIID:	3039618	Length:	710	Species:	Mus musculus

Alignment Length:	614	Identity:	128/614 - (20%)
Similarity:	213/614 - (34%)	Gaps:	224/614 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHSQTMQSIPTLHQPLHS-KVSNYLNNQRRTGQFCDLLLELDSDDSLSLSVHF----CVLAAQS 60
            |:||.|           || .|...|.:||:.|..||:.|.::       :|||    .:|||.|
Mouse    13 MVHSDT-----------HSDTVLASLEDQRKKGFLCDITLIVE-------NVHFRAHKALLAASS 59

  Fly    61 QFINSNQKQQQFSIHNPL--KITIRNFSCTQCLHTIVDFFYEDLVSVSKEHELHFRELAQILAVT 123
            ::.:     ..|:....:  .|.:...........:::|.|...:..|:      :...||||..
Mouse    60 EYFS-----MMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGYLHASE------KTTEQILATA 113

  Fly   124 ELLNLYQL--------------------------------------------------------- 131
            :.|.:|.|
Mouse   114 QFLKVYDLVKAYADFQDNHSAPKPPALNCTGTPVVVISNKKNDPLKRKRGRPRKANGLQEGRSEL 178

  Fly   132 ----------------------------------------QPLGEAKEATEIPAPGEAQPNPDPE 156
                                                    :|.||.....|:||  |...|.||:
Mouse   179 AAEGELQLRVNNSVQNRQNFVFKEEDSVKLSEQTPEDKESEPAGEPGSVEEVPA--EKDENFDPK 241

  Fly   157 KKAEAVFENRQSYFKLKNPRAVK------------SSSKVNYC------IGCDFKCYQVQKMIEH 203
            .......::|.|..:::  |:||            .|:....|      .|.:.:|....::.::
Mouse   242 AGDGQESQSRCSRRRIR--RSVKLKDYKLLGDEDDQSTAKRLCGRKKRSSGPEARCKDCDRVFKY 304

  Fly   204 MGSCEPSHLICSLCEVGFLDWREYDTHLRRHSGDLRKPFFCLQCGIRFNTRAALLVHQPKHSTET 268
                  ||.:.              .|.|||:|:  :||.|.:||..|..:.:|.||...|:.|.
Mouse   305 ------SHFLA--------------IHQRRHTGE--RPFKCNECGKGFAQKHSLQVHTRMHTGER 347

  Fly   269 PHICPHCGKGFKWKQGLSNHILVHNPEKQMLCDVCGYSTTHMKALKSHKLLHTGEF--------- 324
            |:.|..|||....|..|..|:.:|:.:|...||.||...:..:.||||..:|||..
Mouse   348 PYTCTVCGKALTTKHSLLEHMSLHSGQKSFTCDQCGKYFSQKRQLKSHYRVHTGHSLPECSHCHR 412

  Fly   325 --------------------FACTVSGCKHRANRKENLKLHIETHKQGRDFICEVCGCKFSQSKN 369
                                |.|.:.|....|  |.:|:.||..|:..:.:.|.:||..||.|..
Mouse   413 KFMDVSQLKKHLRTHTGEKPFTCEICGKSFTA--KSSLQTHIRIHRGEKPYSCSICGKCFSDSSA 475

  Fly   370 LKRHALKHTENGPNRYKCQLCGFSSHRSDKMKEHVQRVHTEKPVQLELSETVDSSFPDD------ 428
            .:||.:.||  |...:.|..||....|.|.:|.|: ::|:::....: |.:|..|..|:
Mouse   476 KRRHCILHT--GKKPFSCPECGLQFARLDNLKAHL-KIHSKEKHTAD-SSSVSGSNVDEGRNILQ 536

  Fly   429 ---FELPVIETSPKKKPKSVKSKTIRNVN 454
               ::|   .||.:::.:.:.:.::.|:|
Mouse   537 LQPYQL---STSGEQEIQLLVTDSVHNIN 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	66/238 (28%)
		C2H2 Zn finger	214..234	CDD:275368	2/19 (11%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	330..349	CDD:275368	6/18 (33%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		C2H2 Zn finger	387..408	CDD:275368	7/20 (35%)
Zbtb24	NP_700447.2	BTB	27..128	CDD:279045	26/118 (22%)
		BTB	38..133	CDD:197585	21/112 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..176		0/41 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..256		12/55 (22%)
		C2H2 Zn finger	295..315	CDD:275368	5/39 (13%)
		zf-H2C2_2	308..332	CDD:290200	11/39 (28%)
		COG5048	<320..479	CDD:227381	47/160 (29%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..360	CDD:290200	10/24 (42%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	363..388	CDD:290200	8/24 (33%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		COG5048	406..>563	CDD:227381	37/166 (22%)
		C2H2 Zn finger	407..427	CDD:275368	0/19 (0%)
		zf-H2C2_2	420..443	CDD:290200	3/22 (14%)
		C2H2 Zn finger	435..455	CDD:275368	7/21 (33%)
		zf-H2C2_2	447..471	CDD:290200	7/23 (30%)
		C2H2 Zn finger	463..479	CDD:275368	6/15 (40%)
		zf-H2C2_2	477..500	CDD:290200	8/24 (33%)
		C2H2 Zn finger	491..511	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..676
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000