Protein Alignment Tom70 and TOMM70

DIOPT Version :10

• Sequence 1: NP_609536.1
• Gene: Tom70 / 34618
• FlyBaseID: FBgn0032397
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_055635.3
• Gene: TOMM70 / 9868
• HGNCID: 11985
• Length: 608
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 235/592 - (39%)
• Similarity: 354/592 - (59%)
• Gaps: 41/592 - (6%)

  Fly     4 TLNIGSMKLTKWQLALILGTPLAIGLGTYAVKSWT-------------AASKELDGEKKRPKAKI 55
            |...|:..|.:|||||.:|.||.:|.|  |:..|:             |:..:.:.|:|.|:.:.
Human    28 TAGPGTGGLPRWQLALAVGAPLLLGAG--AIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRA 90

  Fly    56 EKQAISLDGTAPDQELERNQKSAELGEKLSPLKEANNYKTEGNNCYRNGKYDEAIKFYDKAIDKC 120
            .....|.....|...|:.|.           |..|...|.:||..::.|||::||:.|.:||..|
Human    91 SPAPGSGHPEGPGAHLDMNS-----------LDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLC 144

  Fly   121 PKEHRTDMAIFYQNRAASYEMLKKWSNVKEDCTASLEFNPRYAKAYYRRARAHEATKDMNECLDD 185
            |.|...|::.|||||||::|.|:||..|.:|||.::|.||:|.||.:|||:|||...:..|||:|
Human   145 PTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLED 209

  Fly   186 VTATCILEMFQNNQTIMFADRVLKETGRLDAEKGMRNRVPVVPSACFVNTYTRSFIADPLQTMKV 250
            |||.||||.|||.|:::.||:|||..|:..|::..:||.|::||..|:.:|..||..|.:....:
Human   210 VTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPML 274

  Fly   251 PAPKSDAPP------------KGFLRAHLAFLEEKYEEIIPACTEEIESSEAEAQYKVEALLMRG 303
            ...|||...            .|:|:|.....||.|::||..|::||   :||.:|..||||:|.
Human   275 KGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEI---DAEGKYMAEALLLRA 336

  Fly   304 TFHLLCGSYVESQQDFDAIIANDYADPNLRAYAYIKRAALYIQLDQREKGIADFAEAERLNPENP 368
            ||:||.|:...::.|.|.:|:...|:..|||.|.|||.::|:|..|......||..|..::|:|.
Human   337 TFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNA 401

  Fly   369 DVYHQRAQILLLLEQIEPALAEFEKAVSIAPNHAIAFVQKCYAEYRLSLLAGDQRRLESVMHTFQ 433
            ||||.|.|:.:||:|:|.|:|:|::.:.:.|..|:|..|||:|.||.:....:..::::.|..|:
Human   402 DVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFE 466

  Fly   434 NAIERFPSCVECYSLTAQVLADQQQFTQAEEYYKKAMVLAPTNPALIVHQAIMVLQWRGDINLAV 498
            ..|::||.|.|.|:|.||.|.|||||.:|:|.|.|.:.|.|.|....||:.::.|||:.|::..:
Human   467 EVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGL 531

  Fly   499 QLLNKAIEVDPKCELAYETLGTVEVQRAQLTRAVELFEKALLYAKSQAELVHVYSLRNAAVAQIN 563
            :|::||||:|.||:.||||:||:||||..:.:|:::|.||:..|||:.|:.|:|||.:||.||..
Human   532 ELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTE 596

  Fly   564 VTKKLGI 570
            |.||.|:
Human   597 VAKKYGL 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tom70	NP_609536.1	3a0801s09	42..567	CDD:273380	216/536 (40%)
		TPR repeat	90..118	CDD:276809	11/27 (41%)
		TPR repeat	123..158	CDD:276809	17/34 (50%)
		TPR repeat	296..324	CDD:276809	12/27 (44%)
		TPR repeat	334..362	CDD:276809	11/27 (41%)
		TPR repeat	367..397	CDD:276809	14/29 (48%)
		TPR repeat	402..437	CDD:276809	10/34 (29%)
		TPR repeat	443..471	CDD:276809	15/27 (56%)
		TPR repeat	476..507	CDD:276809	11/30 (37%)
		TPR repeat	512..539	CDD:276809	13/26 (50%)
TOMM70	NP_055635.3	3a0801s09	41..601	CDD:273380	228/575 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..107		6/39 (15%)
		TPR 1	114..147		14/32 (44%)
		TPR repeat	114..142	CDD:276809	11/27 (41%)
		TPR repeat	152..182	CDD:276809	15/29 (52%)
		TPR 2	153..186		18/32 (56%)
		TPR 3	294..327		13/35 (37%)
		TPR 4	329..362		13/32 (41%)
		TPR repeat	329..357	CDD:276809	12/27 (44%)
		TPR repeat	362..396	CDD:276809	13/33 (39%)
		TPR 5	367..400		12/32 (38%)
		TPR 6	401..434		14/32 (44%)
		TPR repeat	401..429	CDD:276809	13/27 (48%)
		TPR repeat	435..470	CDD:276809	10/34 (29%)
		TPR 7	440..475		11/34 (32%)
		TPR 8	476..509		17/32 (53%)
		TPR repeat	476..504	CDD:276809	15/27 (56%)
		TPR repeat	509..540	CDD:276809	11/30 (37%)
		TPR 9	511..544		12/32 (38%)
		TPR 10	545..578		16/32 (50%)
		TPR repeat	545..572	CDD:276809	13/26 (50%)