DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tom70 and TOMM70

DIOPT Version :9

Sequence 1:NP_609536.1 Gene:Tom70 / 34618 FlyBaseID:FBgn0032397 Length:589 Species:Drosophila melanogaster
Sequence 2:NP_055635.3 Gene:TOMM70 / 9868 HGNCID:11985 Length:608 Species:Homo sapiens


Alignment Length:592 Identity:235/592 - (39%)
Similarity:354/592 - (59%) Gaps:41/592 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 TLNIGSMKLTKWQLALILGTPLAIGLGTYAVKSWT-------------AASKELDGEKKRPKAKI 55
            |...|:..|.:|||||.:|.||.:|.|  |:..|:             |:..:.:.|:|.|:.:.
Human    28 TAGPGTGGLPRWQLALAVGAPLLLGAG--AIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRA 90

  Fly    56 EKQAISLDGTAPDQELERNQKSAELGEKLSPLKEANNYKTEGNNCYRNGKYDEAIKFYDKAIDKC 120
            .....|.....|...|:.|.           |..|...|.:||..::.|||::||:.|.:||..|
Human    91 SPAPGSGHPEGPGAHLDMNS-----------LDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLC 144

  Fly   121 PKEHRTDMAIFYQNRAASYEMLKKWSNVKEDCTASLEFNPRYAKAYYRRARAHEATKDMNECLDD 185
            |.|...|::.|||||||::|.|:||..|.:|||.::|.||:|.||.:|||:|||...:..|||:|
Human   145 PTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLED 209

  Fly   186 VTATCILEMFQNNQTIMFADRVLKETGRLDAEKGMRNRVPVVPSACFVNTYTRSFIADPLQTMKV 250
            |||.||||.|||.|:::.||:|||..|:..|::..:||.|::||..|:.:|..||..|.:....:
Human   210 VTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPML 274

  Fly   251 PAPKSDAPP------------KGFLRAHLAFLEEKYEEIIPACTEEIESSEAEAQYKVEALLMRG 303
            ...|||...            .|:|:|.....||.|::||..|::||   :||.:|..||||:|.
Human   275 KGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEI---DAEGKYMAEALLLRA 336

  Fly   304 TFHLLCGSYVESQQDFDAIIANDYADPNLRAYAYIKRAALYIQLDQREKGIADFAEAERLNPENP 368
            ||:||.|:...::.|.|.:|:...|:..|||.|.|||.::|:|..|......||..|..::|:|.
Human   337 TFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNA 401

  Fly   369 DVYHQRAQILLLLEQIEPALAEFEKAVSIAPNHAIAFVQKCYAEYRLSLLAGDQRRLESVMHTFQ 433
            ||||.|.|:.:||:|:|.|:|:|::.:.:.|..|:|..|||:|.||.:....:..::::.|..|:
Human   402 DVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFE 466

  Fly   434 NAIERFPSCVECYSLTAQVLADQQQFTQAEEYYKKAMVLAPTNPALIVHQAIMVLQWRGDINLAV 498
            ..|::||.|.|.|:|.||.|.|||||.:|:|.|.|.:.|.|.|....||:.::.|||:.|::..:
Human   467 EVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGL 531

  Fly   499 QLLNKAIEVDPKCELAYETLGTVEVQRAQLTRAVELFEKALLYAKSQAELVHVYSLRNAAVAQIN 563
            :|::||||:|.||:.||||:||:||||..:.:|:::|.||:..|||:.|:.|:|||.:||.||..
Human   532 ELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTE 596

  Fly   564 VTKKLGI 570
            |.||.|:
Human   597 VAKKYGL 603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tom70NP_609536.1 TPR_11 89..160 CDD:290150 32/70 (46%)
TPR repeat 90..118 CDD:276809 11/27 (41%)
TPR repeat 123..158 CDD:276809 17/34 (50%)
TPR repeat 296..324 CDD:276809 12/27 (44%)
TPR_11 333..399 CDD:290150 27/65 (42%)
TPR repeat 334..362 CDD:276809 11/27 (41%)
TPR repeat 367..397 CDD:276809 14/29 (48%)
TPR repeat 402..437 CDD:276809 10/34 (29%)
TPR_16 413..477 CDD:290168 25/63 (40%)
TPR repeat 443..471 CDD:276809 15/27 (56%)
TPR repeat 476..507 CDD:276809 11/30 (37%)
TPR_11 486..539 CDD:290150 25/52 (48%)
TPR repeat 512..539 CDD:276809 13/26 (50%)
TOMM70NP_055635.3 3a0801s09 41..601 CDD:273380 228/575 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 67..107 6/39 (15%)
TPR 1 114..147 14/32 (44%)
TPR repeat 114..142 CDD:276809 11/27 (41%)
TPR repeat 152..182 CDD:276809 15/29 (52%)
TPR 2 153..186 18/32 (56%)
TPR 3 294..327 13/35 (37%)
TPR 4 329..362 13/32 (41%)
TPR repeat 329..357 CDD:276809 12/27 (44%)
TPR repeat 362..396 CDD:276809 13/33 (39%)
TPR 5 367..400 12/32 (38%)
TPR 6 401..434 14/32 (44%)
TPR repeat 401..429 CDD:276809 13/27 (48%)
TPR repeat 435..470 CDD:276809 10/34 (29%)
TPR 7 440..475 11/34 (32%)
TPR 8 476..509 17/32 (53%)
TPR repeat 476..504 CDD:276809 15/27 (56%)
TPR repeat 509..540 CDD:276809 11/30 (37%)
TPR 9 511..544 12/32 (38%)
TPR 10 545..578 16/32 (50%)
TPR repeat 545..572 CDD:276809 13/26 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143578
Domainoid 1 1.000 153 1.000 Domainoid score I4307
eggNOG 1 0.900 - - E1_KOG0547
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H40112
Inparanoid 1 1.050 446 1.000 Inparanoid score I1645
Isobase 1 0.950 - 0 Normalized mean entropy S2975
OMA 1 1.010 - - QHG59169
OrthoDB 1 1.010 - - D303136at2759
OrthoFinder 1 1.000 - - FOG0004725
OrthoInspector 1 1.000 - - oto91575
orthoMCL 1 0.900 - - OOG6_104251
Panther 1 1.100 - - LDO PTHR46208
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1535
SonicParanoid 1 1.000 - - X5061
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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