DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom70 and AIP

DIOPT Version :9

Sequence 1:	NP_609536.1	Gene:	Tom70 / 34618	FlyBaseID:	FBgn0032397	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_003968.3	Gene:	AIP / 9049	HGNCID:	358	Length:	330	Species:	Homo sapiens

Alignment Length:	169	Identity:	42/169 - (24%)
Similarity:	67/169 - (39%)	Gaps:	28/169 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ELDGEKKRPKAKI---EKQAISLDGT-APDQELERNQKSAELGEKLSPLKEANNYKTEGNNCYRN 103
            :||..::.|:..|   |...:...|| ..|.....:::.|    |..||     ...|||..||.
Human   137 DLDALQQNPQPLIFHMEMLKVESPGTYQQDPWAMTDEEKA----KAVPL-----IHQEGNRLYRE 192

  Fly   104 GKYDE-AIKFYD----------KAIDKCPKEHRTDMAI--FYQNRAASYEMLKKWSNVKEDCTAS 155
            |...| |.|:||          |.....|:..:.|..|  ...|......:::::..|.:.|::.
Human   193 GHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQLDQQITPLLLNYCQCKLVVEEYYEVLDHCSSI 257

  Fly   156 LEFNPRYAKAYYRRARAHEATKDMNECLDDVTATCILEM 194
            |.......|||::|.:||.|..:..|...|...  :||:
Human   258 LNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAK--VLEL 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom70	NP_609536.1	TPR_11	89..160	CDD:290150	19/83 (23%)
		TPR repeat	90..118	CDD:276809	12/38 (32%)
		TPR repeat	123..158	CDD:276809	6/36 (17%)
		TPR repeat	296..324	CDD:276809
		TPR_11	333..399	CDD:290150
		TPR repeat	334..362	CDD:276809
		TPR repeat	367..397	CDD:276809
		TPR repeat	402..437	CDD:276809
		TPR_16	413..477	CDD:290168
		TPR repeat	443..471	CDD:276809
		TPR repeat	476..507	CDD:276809
		TPR_11	486..539	CDD:290150
		TPR repeat	512..539	CDD:276809
AIP	NP_003968.3	FKBP_C	29..>90	CDD:327575
		TPR 1. /evidence=ECO:0000255, ECO:0000269\|PubMed:23300914	179..212		13/37 (35%)
		TPR repeat	183..225	CDD:276809	13/41 (32%)
		TPR repeat	230..260	CDD:276809	5/29 (17%)
		TPR 2. /evidence=ECO:0000269\|PubMed:23300914	231..264		4/32 (13%)
		TPR 3. /evidence=ECO:0000255, ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:23300914	265..298		11/32 (34%)
		TPR repeat	265..293	CDD:276809	9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030