Protein Alignment Tom70 and TOM71

DIOPT Version :10

• Sequence 1: NP_609536.1
• Gene: Tom70 / 34618
• FlyBaseID: FBgn0032397
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_011985.1
• Gene: TOM71 / 856517
• SGDID: S000001159
• Length: 639
• Species: Saccharomyces cerevisiae
• Alignment Length: 586
• Identity: 155/586 - (26%)
• Similarity: 248/586 - (42%)
• Gaps: 109/586 - (18%)

  Fly    47 EKKRPKAKIEKQAISLDG----TAPDQELERNQKSAELGEKLSPLKE---ANNYKTEGNNCYRNG 104
            :||:.|.|...:|.|.:|    :.|:.|.:..|...     |||.:.   |...|..||:.:...
Yeast    82 KKKKNKRKRNNKAKSGEGFDYPSLPNGEPDIAQLKG-----LSPSQRQAYAVQLKNRGNHFFTAK 141

  Fly   105 KYDEAIKFYDKAIDKCPKEHRTDMAIFYQNRAASYEMLKKWSNVKEDCTASLEFNPRYAKAYYRR 169
            .::||||:|..||:..|.|     .:||.|.:|.|........|.|..|.:||..|.::||..||
Yeast   142 NFNEAIKYYQYAIELDPNE-----PVFYSNISACYISTGDLEKVIEFTTKALEIKPDHSKALLRR 201

  Fly   170 ARAHEATKDMNECLDDVTATCI------------LEMFQNNQTIMFADRVLKETGRLDAEKGMRN 222
            |.|:|:..:..:.:.|::...:            ||...|.|    |.:||.|....|..:|.:
Yeast   202 ASANESLGNFTDAMFDLSVLSLNGDFDGASIEPMLERNLNKQ----AMKVLNENLSKDEGRGSQ- 261

  Fly   223 RVPVVPS----ACF------------VNTYTR-----SFIADPLQTMKVPAPKSDAPPKGFLRAH 266
               |:||    |.|            |||.:.     :.::|.||.:      ..|..:|:|.|:
Yeast   262 ---VLPSNTSLASFFGIFDSHLEVSSVNTSSNYDTAYALLSDALQRL------YSATDEGYLVAN 317

  Fly   267 --LAFLEEKYEEIIPACTEEIESSEAEAQYKVEALLMRGTFHLLCGSYVESQQDFDAIIANDYAD 329
              |....:.|..::.|.|.:....|..|.    ||...|.||.|..:.:::|......| |.:..
Yeast   318 DLLTKSTDMYHSLLSANTVDDPLRENAAL----ALCYTGIFHFLKNNLLDAQVLLQESI-NLHPT 377

  Fly   330 PNLRAYAYIKRAALYIQLDQREKGIADFAEAERLNPENPDVYHQRAQILLLLEQIEPALAEFEKA 394
            ||    :||..|......:..::....|.:|..||||.|..|:.|.|:..:|:..:.|..:|:||
Yeast   378 PN----SYIFLALTLADKENSQEFFKFFQKAVDLNPEYPPTYYHRGQMYFILQDYKNAKEDFQKA 438

  Fly   395 VSIAPNHAIAFVQKCYAEYRLSLLAGDQRRLESVMHTFQNAIERFPSCVECYSLTAQVLADQQQF 459
            .|:.|.:...::|       |:.|...|.:.......|.....:||:..|..:..|::|.|:..|
Yeast   439 QSLNPENVYPYIQ-------LACLLYKQGKFTESEAFFNETKLKFPTLPEVPTFFAEILTDRGDF 496

  Fly   460 TQA----------EEYYKKAMV-LAPTNPALIVHQAIMVLQWRGD--------INLAVQLLNKAI 505
            ..|          ||..:|..| :.|    ||....|:..|...|        .|.|::||.||.
Yeast   497 DTAIKQYDIAKRLEEVQEKIHVGIGP----LIGKATILARQSSQDPTQLDEEKFNAAIKLLTKAC 557

  Fly   506 EVDPKCELAYETLGTVEVQRAQLTRAVELFEKALLYAKSQAELVHVYSLRNAAVAQINVTKKLGI 570
            |:||:.|.|...|..:::|..::..|:||||.:.:.|::..|.:...:...||    .:.|:|..
Yeast   558 ELDPRSEQAKIGLAQLKLQMEKIDEAIELFEDSAILARTMDEKLQATTFAEAA----KIQKRLRA 618

  Fly   571 D 571
            |
Yeast   619 D 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tom70	NP_609536.1	3a0801s09	42..567	CDD:273380	152/580 (26%)
		TPR repeat	90..118	CDD:276809	10/27 (37%)
		TPR repeat	123..158	CDD:276809	10/34 (29%)
		TPR repeat	296..324	CDD:276809	7/27 (26%)
		TPR repeat	334..362	CDD:276809	5/27 (19%)
		TPR repeat	367..397	CDD:276809	9/29 (31%)
		TPR repeat	402..437	CDD:276809	5/34 (15%)
		TPR repeat	443..471	CDD:276809	9/37 (24%)
		TPR repeat	476..507	CDD:276809	11/38 (29%)
		TPR repeat	512..539	CDD:276809	9/26 (35%)
TOM71	NP_011985.1	3a0801s09	9..636	CDD:273380	155/586 (26%)
		TPR repeat	127..155	CDD:276809	10/27 (37%)
		TPR repeat	160..190	CDD:276809	10/34 (29%)
		TPR repeat	195..218	CDD:276809	7/22 (32%)
		TPR repeat	345..373	CDD:276809	9/32 (28%)
		TPR repeat	378..406	CDD:276809	7/31 (23%)
		TPR repeat	411..441	CDD:276809	9/29 (31%)
		TPR repeat	446..471	CDD:276809	5/31 (16%)
		TPR repeat	480..508	CDD:276809	6/27 (22%)
		TPR repeat	513..559	CDD:276809	14/49 (29%)
		TPR repeat	564..588	CDD:276809	7/23 (30%)