DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom70 and TOM70

DIOPT Version :9

Sequence 1:	NP_609536.1	Gene:	Tom70 / 34618	FlyBaseID:	FBgn0032397	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_014278.3	Gene:	TOM70 / 855602	SGDID:	S000005065	Length:	617	Species:	Saccharomyces cerevisiae

Alignment Length:	654	Identity:	152/654 - (23%)
Similarity:	261/654 - (39%)	Gaps:	135/654 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LALILGTPLAIGLGTYAVKSWTAASKELDGEKKRPKAKIEKQAISLDGTAPDQELERNQKS-AEL 80
            ||.:..|..|||...|    :....::....||....|.||:    |.....:|.|..:|| |..
Yeast    13 LATVAATGTAIGAYYY----YNQLQQQQQRGKKNTINKDEKK----DTKDSQKETEGAKKSTAPS 69

  Fly    81 GEKLSPL----------------KEANNY----KTEGNNCYRNGKYDEAIKFYDKAIDKCPKEHR 125
            ...:.|:                :|.:.|    |.:||..:||.|||:|||:|:.|:     |.:
Yeast    70 NPPIYPVSSNGEPDFSNKANFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWAL-----ELK 129

  Fly   126 TDMAIFYQNRAASYEMLKKWSNVKEDCTASLEFNPRYAKAYYRRARAHE------------ATKD 178
            .| .:||.|.:|.|..:.....|.|..|.:||..|.|:|...|||.|:|            :...
Yeast   130 ED-PVFYSNLSACYVSVGDLKKVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSVLS 193

  Fly   179 MNECLDDVTATCILEMFQNNQTIMFADRVLKETGRLDA---------------EKGMRNRVPVV- 227
            :|...:|.:...:||...|.|.:   .::.::.|.:|.               .|..:..:|.|
Yeast   194 LNGDFNDASIEPMLERNLNKQAM---SKLKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVT 255

  Fly   228 ----------PSACFVNTYTRSFIADP-----LQTMKVPAPKS-DAPPKGFLRAHLAFLEEKYEE 276
                      |...|.| |..|..||.     |..:...:|:| |...:.|.:|...|
Yeast   256 SMASFFGIFKPELTFAN-YDESNEADKELMNGLSNLYKRSPESYDKADESFTKAARLF------- 312

  Fly   277 IIPACTEEIESSEAEAQYKVE---ALLMRGTFHLLCGSYVESQQDFDAIIANDYADPNLRAYAYI 338
                 .|:::.:..:.:.|.:   :|...|.|..|....:.:.:|....|.   ..|.:.:|.|:
Yeast   313 -----EEQLDKNNEDEKLKEKLAISLEHTGIFKFLKNDPLGAHEDIKKAIE---LFPRVNSYIYM 369

  Fly   339 KRAALYIQLDQREKGIADFAEAERLNPENPDVYHQRAQILLLLEQIEPALAEFEKAVSIAPNHAI 403
              |.:....:...:....|.:|.:|:..|..||:.|.|:..:|:..:.|..:|:||..:.|.:..
Yeast   370 --ALIMADRNDSTEYYNYFDKALKLDSNNSSVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIF 432

  Fly   404 AFVQKCYAEYRLSLLAGDQRRLESVMHTFQNAIERFPSCVECYSLTAQVLADQQQFTQAEEYYKK 468
            .::|       |:.||..:.:.:.....|..|..:||...|..:..|::|.|:..|.:|.:.|..
Yeast   433 PYIQ-------LACLAYRENKFDDCETLFSEAKRKFPEAPEVPNFFAEILTDKNDFDKALKQYDL 490

  Fly   469 AMVLAPTNPALIVHQAIMVLQWRGDINL------------AVQLLNKAIEVDPKCELAYETLGTV 521
            |:.|......:.|..|.:|    |...|            |..||.||.::||:.|.|...|..:
Yeast   491 AIELENKLDGIYVGIAPLV----GKATLLTRNPTVENFIEATNLLEKASKLDPRSEQAKIGLAQM 551

  Fly   522 EVQRAQLTRAVELFEKALLYAKSQAELVHVYSLRNAAVAQINV------TKKLGIDMNSVSAMAQ 580
            ::|:..:..|:.|||::...|::..|.:...:...||..|..:      .||:   ..:::.:.:
Yeast   552 KLQQEDIDEAITLFEESADLARTMEEKLQAITFAEAAKVQQRIRSDPVLAKKI---QETLAKLRE 613

  Fly   581 SGLM 584
            .|||
Yeast   614 QGLM 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom70	NP_609536.1	TPR_11	89..160	CDD:290150	27/74 (36%)
		TPR repeat	90..118	CDD:276809	14/31 (45%)
		TPR repeat	123..158	CDD:276809	11/34 (32%)
		TPR repeat	296..324	CDD:276809	5/30 (17%)
		TPR_11	333..399	CDD:290150	16/65 (25%)
		TPR repeat	334..362	CDD:276809	5/27 (19%)
		TPR repeat	367..397	CDD:276809	10/29 (34%)
		TPR repeat	402..437	CDD:276809	6/34 (18%)
		TPR_16	413..477	CDD:290168	16/63 (25%)
		TPR repeat	443..471	CDD:276809	8/27 (30%)
		TPR repeat	476..507	CDD:276809	10/42 (24%)
		TPR_11	486..539	CDD:290150	18/64 (28%)
		TPR repeat	512..539	CDD:276809	8/26 (31%)
TOM70	NP_014278.3	3a0801s09	1..614	CDD:273380	149/649 (23%)
		TPR repeat	99..127	CDD:276809	13/32 (41%)
		TPR repeat	131..161	CDD:276809	10/30 (33%)
		TPR repeat	166..189	CDD:276809	6/22 (27%)
		TPR repeat	330..358	CDD:276809	5/27 (19%)
		TPR repeat	363..391	CDD:276809	5/29 (17%)
		TPR repeat	396..426	CDD:276809	10/29 (34%)
		TPR repeat	431..459	CDD:276809	6/34 (18%)
		TPR repeat	465..493	CDD:276809	8/27 (30%)
		TPR repeat	498..537	CDD:276809	10/42 (24%)
		TPR repeat	542..567	CDD:276809	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0547
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40112
Inparanoid	1	1.050	126	1.000	Inparanoid score	I1274
Isobase	1	0.950	-	0	Normalized mean entropy	S2975
OMA	1	1.010	-	-		QHG59169
OrthoFinder	1	1.000	-	-		FOG0004725
OrthoInspector	1	1.000	-	-		otm46953
orthoMCL	1	0.900	-	-		OOG6_104251
Panther	1	1.100	-	-	LDO	PTHR46208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.780