DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tom70 and TTC1

DIOPT Version :9

Sequence 1:NP_609536.1 Gene:Tom70 / 34618 FlyBaseID:FBgn0032397 Length:589 Species:Drosophila melanogaster
Sequence 2:NP_001269429.1 Gene:TTC1 / 7265 HGNCID:12391 Length:292 Species:Homo sapiens


Alignment Length:279 Identity:71/279 - (25%)
Similarity:122/279 - (43%) Gaps:46/279 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IGSMKLTKWQLALILGTPLAIGLGTYA----VKSWTAASKELDGE-----------KKRPKA-KI 55
            :..:|:|..|.|...|.|:......::    ::...|..:|..||           ::.|.| |:
Human    15 LNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKV 79

  Fly    56 E-KQAISLDGTAPDQ----ELERNQKSAELGEKLSPLKEANNYKTEGNNCYRNGKYDEAIKFYDK 115
            | |....::.:..|:    |||:|....   ||....:|:...|.|||..::.|.|.||...|.:
Human    80 ENKSNEDVNSSELDEEYLIELEKNMSDE---EKQKRREESTRLKEEGNEQFKKGDYIEAESSYSR 141

  Fly   116 AIDKCPKEHRTDMAIFYQNRAASYEMLKKWSNVKEDCTASLEFNPRYAKAYYRRARAHEATKDMN 180
            |::.||...:.:.:|.:.||||:.....|......||:.:::.||.|.:|..|||..:|.|..::
Human   142 ALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLD 206

  Fly   181 ECLDDVTATCILE----MFQNNQTIMFADRVLKETG-RLDAE-----KGMRNRV--PV------- 226
            |.|:|..:  |||    :.|..:..|...:.::|.. ||..|     |.:.|.|  |.       
Human   207 EALEDYKS--ILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENF 269

  Fly   227 -VPSACFVNTYTRSFIADP 244
             :.......:|:.:|:.:|
Human   270 QIKQDSSTGSYSINFVQNP 288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tom70NP_609536.1 TPR_11 89..160 CDD:290150 21/70 (30%)
TPR repeat 90..118 CDD:276809 10/27 (37%)
TPR repeat 123..158 CDD:276809 8/34 (24%)
TPR repeat 296..324 CDD:276809
TPR_11 333..399 CDD:290150
TPR repeat 334..362 CDD:276809
TPR repeat 367..397 CDD:276809
TPR repeat 402..437 CDD:276809
TPR_16 413..477 CDD:290168
TPR repeat 443..471 CDD:276809
TPR repeat 476..507 CDD:276809
TPR_11 486..539 CDD:290150
TPR repeat 512..539 CDD:276809
TTC1NP_001269429.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 23..125 24/104 (23%)
TPR 1 116..149 12/32 (38%)
TPR_11 119..186 CDD:290150 20/66 (30%)
TPR repeat 119..144 CDD:276809 10/24 (42%)
TPR repeat 149..184 CDD:276809 8/34 (24%)
TPR_11 154..220 CDD:290150 23/67 (34%)
TPR 2 155..188 10/32 (31%)
TPR_1 158..188 CDD:278916 9/29 (31%)
TPR 3 189..222 12/34 (35%)
TPR 189..221 CDD:197478 12/33 (36%)
TPR repeat 189..217 CDD:276809 10/29 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D594913at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.