DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom70 and ttc6

DIOPT Version :9

Sequence 1:	NP_609536.1	Gene:	Tom70 / 34618	FlyBaseID:	FBgn0032397	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_009291126.1	Gene:	ttc6 / 568208	ZFINID:	ZDB-GENE-090429-2	Length:	1760	Species:	Danio rerio

Alignment Length:	613	Identity:	125/613 - (20%)
Similarity:	223/613 - (36%)	Gaps:	167/613 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AKIEKQAISLDGTAPD--QELERNQKSAELGEKLSPLKEANNYKTEGNNCYRNGKYDEAIKFYDK 115
            |.:|:..:|.|....|  :.::....:|:|..:::.|.:|   .|||.|  ||
Zfish   737 AALEENQLSQDEDKLDMCEVVDEGLSTADLEHEVAKLTQA---LTEGGN--RN------------ 784

  Fly   116 AIDKCPKEHRTDMAIFYQNRAASYEMLKKWSNVKEDCTASLEFNPRYAKAYYRRARAHEATKDMN 180
            |.|:|             .|.|.|..|.......||.:|::...|....||:.|...:....|..
Zfish   785 AFDRC-------------RRGALYIKLGYLEQALEDLSAAISLEPHLLDAYWHRHSIYLLRNDPV 836

  Fly   181 ECLDDVTATCILEMFQNNQ----TIMFADRVLKETGRLDAEKGMRNRVPVVPSACFVNTYTRSFI 241
            ..|||:..     :..||:    ..|....:.|:.|.             ...|.|  :||
Zfish   837 RALDDLNV-----IVTNNKKHADAFMSRAEIYKQRGE-------------TTLALF--SYT---- 877

  Fly   242 ADPLQTMKVPAPKSDAPPKGFLRAHLAFLEEKYEEIIPACTEEIESSEAEAQYKVEALLMRGTFH 306
                |.:||   |.|.....|.||.   :.:|..||:.|..:..::...:.. :.:|:::.|..|
Zfish   878 ----QAIKV---KPDDAEIYFKRAK---MYDKMGEILLAMEDYAKTFTIDPT-RTDAMMLHGMHH 931

  Fly   307 LLCGSYVESQQDFDAIIANDYADPNLRAYAYIKRAALYIQLDQREKGIADFAEAERLNP------ 365
            .....:..|.:||..::..:..:...|.|    |..:|.:|...||.:.|.:.|..|||
Zfish   932 FNSSKWTVSLEDFSLLLKQEPDNAIARTY----RGRIYSKLGHFEKSVEDLSLAVHLNPADWLAF 992

  Fly   366 -----------------------------ENPDVYHQRAQILLLLEQIEPALAEFEKAVSIAPNH 401
                                         ||...:..|..:.:.|:..:.|:|:||..:.:..:.
Zfish   993 YHRGCLLREIMPHLALRDFSTSVLINDSAENWRAFLHRGMVYVTLQHWQQAIADFEAVIKLDRSA 1057

  Fly   402 AIAFVQKCYAEYRLSLLAGDQRRLESVMHTFQNAIERFPSCVECYSLTAQVLADQQQFTQAEEYY 466
            |:|.|..    ..:.:|..| |..|:: ..|.||::..|:.|:.|...|:...:....::|.:..
Zfish  1058 AVAHVNL----GMICMLKMD-RHYEAI-RRFNNALKADPTYVKAYVCRARAFYNVNNLSKAVKDL 1116

  Fly   467 KKAMVLAPTNPALIVHQ------------AIMVLQWRGDINLAVQL------------------- 500
            .:|:.|.|....|.:.:            |.:.:|:..::..|:.|
Zfish  1117 TRAIHLKPDAYDLYIMRGKFFYEMKCFDLAALCIQYAAEMKTALGLSAVQQAVIQSFLGNDANAI 1181

  Fly   501 --LNKAIEVDPKCELAYETLGTVEVQRAQLTRAVELFEKALLY----------AKSQAELVHVYS 553
              |.:|::..|...... .||...::..:.|.|||.|:|||.:          ||..||:.::
Zfish  1182 VCLEQAVDTQPSPPHLI-LLGRTLMKEHRFTEAVETFKKALSFLGSTKAKLSPAKETAEVFYL-- 1243

  Fly   554 LRNAAVAQINVTKKLGIDMNSVSAMAQS 581
                 :....||::|....:..|.:.|:
Zfish  1244 -----IGVCYVTQRLLFQESGDSLLLQA 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom70	NP_609536.1	TPR_11	89..160	CDD:290150	17/70 (24%)
		TPR repeat	90..118	CDD:276809	8/27 (30%)
		TPR repeat	123..158	CDD:276809	7/34 (21%)
		TPR repeat	296..324	CDD:276809	6/27 (22%)
		TPR_11	333..399	CDD:290150	20/100 (20%)
		TPR repeat	334..362	CDD:276809	8/27 (30%)
		TPR repeat	367..397	CDD:276809	7/29 (24%)
		TPR repeat	402..437	CDD:276809	10/34 (29%)
		TPR_16	413..477	CDD:290168	15/63 (24%)
		TPR repeat	443..471	CDD:276809	5/27 (19%)
		TPR repeat	476..507	CDD:276809	7/63 (11%)
		TPR_11	486..539	CDD:290150	14/73 (19%)
		TPR repeat	512..539	CDD:276809	8/26 (31%)
ttc6	XP_009291126.1	TPR_11	784..850	CDD:290150	20/95 (21%)
		TPR repeat	784..814	CDD:276809	11/54 (20%)
		TPR repeat	852..882	CDD:276809	8/52 (15%)
		TPR	871..1146	CDD:223533	61/301 (20%)
		TPR repeat	887..912	CDD:276809	7/27 (26%)
		TPR repeat	922..946	CDD:276809	6/23 (26%)
		TPR repeat	955..983	CDD:276809	9/31 (29%)
		TPR repeat	988..1017	CDD:276809	0/28 (0%)
		TPR repeat	1025..1052	CDD:276809	6/26 (23%)
		TPR repeat	1057..1088	CDD:276809	10/36 (28%)
		TPR repeat	1093..1120	CDD:276809	4/26 (15%)
		TPR repeat	1127..1155	CDD:276809	3/27 (11%)
		TPR_11	1154..1222	CDD:290150	14/68 (21%)
		TPR repeat	1161..1189	CDD:276809	3/27 (11%)
		TPR	1217..1486	CDD:223533	13/57 (23%)
		TPR repeat	1238..1275	CDD:276809	7/36 (19%)
		TPR repeat	1281..1308	CDD:276809
		TPR repeat	1314..1342	CDD:276809
		TPR repeat	1347..1377	CDD:276809
		TPR repeat	1382..1405	CDD:276809
		TPR repeat	1418..1448	CDD:276809
		TPR	1432..1721	CDD:223533
		TPR_2	1453..1484	CDD:285020
		TPR repeat	1453..1481	CDD:276809
		TPR repeat	1487..1517	CDD:276809
		TPR repeat	1526..1552	CDD:276809
		TPR repeat	1560..1586	CDD:276809
		TPR repeat	1593..1620	CDD:276809
		TPR	1626..1659	CDD:197478
		TPR repeat	1626..1654	CDD:276809
		TPR repeat	1659..1689	CDD:276809
		TPR_11	1693..1757	CDD:290150
		TPR repeat	1694..1721	CDD:276809
		TPR repeat	1728..1756	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303136at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920