Protein Alignment Tom70 and Stip1

DIOPT Version :10

• Sequence 1: NP_609536.1
• Gene: Tom70 / 34618
• FlyBaseID: FBgn0032397
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_477354.1
• Gene: Stip1 / 33202
• FlyBaseID: FBgn0024352
• Length: 490
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 106/584 - (18%)
• Similarity: 199/584 - (34%)
• Gaps: 188/584 - (32%)

  Fly    87 LKEANNYKTEGNNCYRNGKYDEAIKFYDKAIDKCPKEHRTDMAIFYQNRAASYEMLKKWSNVKED 151
            :.:.|..|.:||......|:|||:..|.:||....:.|     :.|.||:|::....|:....||
  Fly     1 MDKVNELKEKGNQALSAEKFDEAVAAYTEAIALDDQNH-----VLYSNRSAAFAKAGKFQEALED 60

  Fly   152 CTASLEFNPRYAKAYYRRARAHEATKDM-------NECLD-DVTATCILEMFQNNQTIMFADRVL 208
            ...:::.||.:.|.|.|:..|.....|.       ||.|. |.|...:|:  ...:|...|...:
  Fly    61 AEKTIQLNPTWPKGYSRKGAAAAGLNDFMKAFEAYNEGLKYDPTNAILLQ--GRMETTASALSFM 123

  Fly   209 KETGRL----DAEKGMRNRVPVVPSACFVNTYTRSFIADPLQTMKVPAPK-----SDAPPKGFLR 264
            :..|.:    |.::....|.|..|.            |.|.:..|...|:     .:...|.|.|
  Fly   124 QSQGDIPMDVDPQQARSRRAPSPPP------------AKPAEPPKPAEPRVEDMTEEQKNKYFAR 176

  Fly   265 ---------------------------------------AHLAFLEEKYEEIIPACTEEIE-SSE 289
                                                   |.:.|..::|||.|..|.:.|| ..|
  Fly   177 KEKELGNAAYKKKDFETALKHYHAAIEHDPTDITFYNNIAAVHFERKEYEECIKQCEKGIEVGRE 241

  Fly   290 AEAQYKV--EALLMRGTFHLLCGSYVESQQDFDAIIANDYADPNLRA--------------YAYI 338
            :.|.:|:  ::....|..:....:|.:::..::..: :::..|.::.              .|||
  Fly   242 SRADFKLIAKSFARIGNTYRKLENYKQAKVYYEKAM-SEHRTPEIKTSLSEVEAKIKEEERMAYI 305

  Fly   339 ---------KRAALYIQLDQREKGIADFAEAERLNPENPDVYHQRAQILLLLEQIEPALAEFEKA 394
                     ::..|:.:.......:..:.||.:.||::|.:|..||.....|...:..|.:.:..
  Fly   306 NPEKAEEEKEQGNLFFKKGDYSTAVKHYTEAIKRNPDDPKLYSNRAACYTKLAAFDLGLKDCDTC 370

  Fly   395 VSIAPNHAIAFVQKCYAEYRLSLLAGDQRRLESVMHTFQNAIERFPSCVECYSLTAQVLADQQQF 459
            :.:.                                      |:|   ::.|....::|...||.
  Fly   371 IKLD--------------------------------------EKF---IKGYIRKGKILQGMQQQ 394

  Fly   460 TQAEEYYKKAMVLAPTNPALIVHQAIMVLQWRGDINLAVQLLNKAIEVDPKCELAYETLGTVEVQ 524
            ::|:..|:||:.|.|.|.                         :|||...:|.:.:        |
  Fly   395 SKAQAAYQKALELDPNNA-------------------------EAIEGYRQCSMNF--------Q 426

  Fly   525 RAQLTRAVELFEKALLYAKSQAELVHVYSLRNAAVAQINVTKKLGIDMNSVSAMAQSGLMAQGV 588
            |..        ::.|..|.|..|:..:  |::.|:..|  .:::..|.|:|....|:..:|..:
  Fly   427 RNP--------QEVLKNAMSDPEIQQI--LKDPAMRMI--LEQMQSDPNAVKEHLQNPAIADKI 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tom70	NP_609536.1	3a0801s09	42..567	CDD:273380	101/561 (18%)
		TPR repeat	90..118	CDD:276809	10/27 (37%)
		TPR repeat	123..158	CDD:276809	8/34 (24%)
		TPR repeat	296..324	CDD:276809	2/29 (7%)
		TPR repeat	334..362	CDD:276809	6/50 (12%)
		TPR repeat	367..397	CDD:276809	6/29 (21%)
		TPR repeat	402..437	CDD:276809	0/34 (0%)
		TPR repeat	443..471	CDD:276809	8/27 (30%)
		TPR repeat	476..507	CDD:276809	3/30 (10%)
		TPR repeat	512..539	CDD:276809	2/26 (8%)
Stip1	NP_477354.1	TPR repeat	7..32	CDD:276809	9/24 (38%)
		TPR	10..276	CDD:440225	58/284 (20%)
		TPR repeat	37..67	CDD:276809	8/34 (24%)
		TPR repeat	72..100	CDD:276809	7/27 (26%)
		LapB	173..415	CDD:442196	44/308 (14%)
		TPR repeat	175..203	CDD:276809	1/27 (4%)
		TPR repeat	208..238	CDD:276809	8/29 (28%)
		TPR repeat	250..278	CDD:276809	2/28 (7%)
		TPR repeat	310..338	CDD:276809	3/27 (11%)
		TPR repeat	343..373	CDD:276809	6/29 (21%)
		TPR repeat	378..406	CDD:276809	8/27 (30%)
		STI1	429..482	CDD:436075	12/62 (19%)