DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tom70 and tomm34

DIOPT Version :9

Sequence 1:NP_609536.1 Gene:Tom70 / 34618 FlyBaseID:FBgn0032397 Length:589 Species:Drosophila melanogaster
Sequence 2:NP_955932.2 Gene:tomm34 / 323361 ZFINID:ZDB-GENE-030131-2081 Length:305 Species:Danio rerio


Alignment Length:337 Identity:90/337 - (26%)
Similarity:130/337 - (38%) Gaps:68/337 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 KTEGNNCYRNGKYDEAIKFYDKAI---DKCPKEHRTDMAIFYQNRAASYEMLKKWSNVKE---DC 152
            |..||.|::.|:|.||:..|.:||   :|..::...|:.|.|.||||||   .|..|..|   ||
Zfish    14 KQAGNECFKAGQYGEAVTLYSQAIQQLEKSGQKKTEDLGILYSNRAASY---LKDGNCNECIKDC 75

  Fly   153 TASLEFNPRYAKAYYRRARAHEATKDMNECLDDVTATCILEMFQNNQTIMFA----DRVLKETGR 213
            ||||:..|...||..|||.|.||.:...:...|...     :.|.:..|..|    :|:.|....
Zfish    76 TASLDLVPFGFKALLRRAAAFEALERYRQAYVDYKT-----VLQIDWNIPAAHDGVNRMTKALTE 135

  Fly   214 LDAEKGMRNRVPVVPSACFVNTYTRSFIADPLQTM--------KVPAPKSDAPPKGFLRAHLAFL 270
            :|. ...|.::|.:|:............|.|..:.        |..||..||..||      ..|
Zfish   136 MDG-PSWREKLPPIPTVPMSVKEKLGQAASPASSSQQNNVIDDKKKAPGPDAVKKG------RTL 193

  Fly   271 EEKYEEIIPACTEEIESSEAEAQYKVEALLMRGTFHLLCGSYVESQQDFDAIIANDYADPNLRAY 335
            :|                      :..||:.:|........|.:|       :|.|..:    ..
Zfish   194 KE----------------------EGNALVKKGEHKKAMEKYTQS-------LAQDPTE----VT 225

  Fly   336 AYIKRAALYIQLDQREKGIADFAEAERLNPENPDVYHQRAQILLLLEQIEPALAEFEKAVSIAPN 400
            .|..||..|:.|...:..|.|..||.||:..|....::|||....|:..:..:.:....:.|.||
Zfish   226 TYTNRALCYLALKMYKDAIRDCEEALRLDSANIKALYRRAQAYKELKNKKSCIEDLNSVLKIDPN 290

  Fly   401 HAIAFVQKCYAE 412
            :..  |||...|
Zfish   291 NTA--VQKLLQE 300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tom70NP_609536.1 TPR_11 89..160 CDD:290150 30/71 (42%)
TPR repeat 90..118 CDD:276809 11/26 (42%)
TPR repeat 123..158 CDD:276809 18/37 (49%)
TPR repeat 296..324 CDD:276809 5/27 (19%)
TPR_11 333..399 CDD:290150 17/65 (26%)
TPR repeat 334..362 CDD:276809 9/27 (33%)
TPR repeat 367..397 CDD:276809 5/29 (17%)
TPR repeat 402..437 CDD:276809 4/11 (36%)
TPR_16 413..477 CDD:290168 90/337 (27%)
TPR repeat 443..471 CDD:276809
TPR repeat 476..507 CDD:276809
TPR_11 486..539 CDD:290150
TPR repeat 512..539 CDD:276809
tomm34NP_955932.2 TPR_11 13..83 CDD:290150 30/71 (42%)
TPR repeat 13..38 CDD:276809 10/23 (43%)
TPR repeat 43..81 CDD:276809 18/40 (45%)
TPR_11 54..116 CDD:290150 27/69 (39%)
TPR repeat 86..114 CDD:276809 9/32 (28%)
TPR_11 191..254 CDD:290150 19/95 (20%)
TPR repeat 191..218 CDD:276809 7/55 (13%)
TPR repeat 223..253 CDD:276809 9/33 (27%)
TPR_11 226..289 CDD:290150 17/62 (27%)
TPR 226..257 CDD:197478 11/30 (37%)
TPR_1 258..291 CDD:278916 6/32 (19%)
TPR repeat 258..286 CDD:276809 4/27 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1535
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

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