DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom70 and TTC6

DIOPT Version :9

Sequence 1:	NP_609536.1	Gene:	Tom70 / 34618	FlyBaseID:	FBgn0032397	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_024305328.1	Gene:	TTC6 / 319089	HGNCID:	19739	Length:	1910	Species:	Homo sapiens

Alignment Length:	634	Identity:	143/634 - (22%)
Similarity:	227/634 - (35%)	Gaps:	167/634 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QAISLDGTAPDQELERNQKSAELGEKLSPLKEANN-------YKTEGNNCY-RNGKYDEAIKFYD 114
            :||.:|.......|.|    ||...||..||:|.|       .:.:|...| |.|:|...:|:||
Human  1231 EAIRIDPLCIQSYLCR----AETYFKLHKLKKAVNELSRAIHLQPDGIQLYIRRGQYLLMMKYYD 1291

  Fly   115 KA---------IDKCPKE-HRTDMAIFY---QNRAASYEMLK--KWSNVKEDCTASLEFNPRYAK 164
            .|         :||...| .....|:.|   :|...:.|:|.  .|:..:....|.|      ||
Human  1292 LAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCALL------AK 1350

  Fly   165 AYYRRARAHEATKDMNECLD---------DVTA----------TCILEMFQNNQTIMFADRVLKE 210
            ...:..|..||.:.:.:.||         |.||          .|.:|  :.|..:.|.......
Human  1351 VQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYME--EGNLQMAFDSFTKAV 1413

  Fly   211 TGRLDAEKGMRNRVPVVPSACFVNTYTRSFIADPLQTMKVPAPKSDAPPKGFLRAHL---AF--L 270
            ....|..:....|     ..|.|..:..|.|.|..:.:.:..........|.|.|:|   ||  |
Human  1414 KANPDFAESFYQR-----GLCKVKLHKDSSILDFNRAITLNPKHYQEMHTGGLGAYLSRVAFYGL 1473

  Fly   271 EEKYEEIIPACTEEI----ESSEAEAQYKVEALLMRG-------TFHL----------------- 307
            :.:|.:.|..|.:.|    ||        |.|.|.||       |:.|
Human  1474 KGRYSKAILNCNKAIKIYPES--------VRAYLYRGVLKYYNKTYKLAITDLTTAISMDKNSYT 1530

  Fly   308 ------LCGSYVESQQ----DFDAIIANDYADPNLRAYAYIKRAALYIQLDQREKGIADFAEAER 362
                  ||.:.:...|    |:..::..| |...::...::.|..:|::|.|....:.||.:|..
Human  1531 AFYNRALCYTKIRELQMALTDYGIVLLLD-ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAAL 1594

  Fly   363 LNPENPDVYHQRAQILLLLEQIEPALAEFEKAVSIAPNHAIAFVQK--CYAEYRLSLLAGDQRRL 425
            ::..|..:.|..|.....:.:.|.|:..|..|:.|.|....|:|.:  .|.||      |.....
Human  1595 ISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEY------GHDEAT 1653

  Fly   426 ESVMHTFQNAIERFPSCVEC-----YSLTAQVLADQQQFTQAEEYYKKAMVLAPTNPALIVHQAI 485
            :.....|..|:...|:.::.     |:|.|     |.:|.:|..::..|:...|.|......:|:
Human  1654 KQAQKDFLKALHINPAYIKARISFGYNLQA-----QGKFQKAWNHFTIAIDTDPKNYLAYEGRAV 1713

  Fly   486 MVLQWRG------DINLAVQ-------LLNK-------------------AIEVDPKCELAYETL 518
            :.||...      |||.|::       |.|:                   ||.::||..|||...
Human  1714 VCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1778

  Fly   519 GTVEVQRAQLTRAVELFEKALLYAKSQAELVHVYSLRNAAVAQINVTKK 567
            |.:.....|.::|.:.|.|||.:     :..:.|.|.|.|:.. .:.||
Human  1779 GNIYFHHRQFSQASDYFSKALKF-----DPENEYVLMNRAITN-TILKK 1821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom70	NP_609536.1	TPR_11	89..160	CDD:290150	22/93 (24%)
		TPR repeat	90..118	CDD:276809	11/44 (25%)
		TPR repeat	123..158	CDD:276809	9/40 (23%)
		TPR repeat	296..324	CDD:276809	11/61 (18%)
		TPR_11	333..399	CDD:290150	15/65 (23%)
		TPR repeat	334..362	CDD:276809	7/27 (26%)
		TPR repeat	367..397	CDD:276809	7/29 (24%)
		TPR repeat	402..437	CDD:276809	8/36 (22%)
		TPR_16	413..477	CDD:290168	13/68 (19%)
		TPR repeat	443..471	CDD:276809	7/32 (22%)
		TPR repeat	476..507	CDD:276809	12/62 (19%)
		TPR_11	486..539	CDD:290150	20/84 (24%)
		TPR repeat	512..539	CDD:276809	8/26 (31%)
TTC6	XP_024305328.1	TPR repeat	933..961	CDD:276809
		TPR_11	940..1832	CDD:330823	143/634 (23%)
		TPR repeat	966..996	CDD:276809
		TPR repeat	1002..1029	CDD:276809
		TPR repeat	1034..1063	CDD:276809
		TPR repeat	1069..1096	CDD:276809
		TPR repeat	1101..1131	CDD:276809
		TPR repeat	1173..1199	CDD:276809
		TPR repeat	1207..1234	CDD:276809	1/2 (50%)
		TPR repeat	1239..1269	CDD:276809	10/33 (30%)
		TPR repeat	1308..1333	CDD:276809	5/24 (21%)
		TPR repeat	1347..1370	CDD:276809	6/28 (21%)
		TPR repeat	1386..1414	CDD:276809	4/29 (14%)
		TPR repeat	1419..1448	CDD:276809	6/33 (18%)
		TPR repeat	1463..1489	CDD:276809	8/25 (32%)
		TPR repeat	1494..1524	CDD:276809	8/37 (22%)
		TPR repeat	1529..1552	CDD:276809	3/22 (14%)
		TPR repeat	1568..1594	CDD:276809	7/25 (28%)
		TPR repeat	1599..1629	CDD:276809	7/29 (24%)
		TPR repeat	1634..1664	CDD:276809	7/35 (20%)
		TPR repeat	1671..1699	CDD:276809	7/32 (22%)
		TPR repeat	1704..1734	CDD:276809	8/29 (28%)
		TPR repeat	1738..1766	CDD:276809	3/27 (11%)
		TPR repeat	1774..1800	CDD:276809	8/25 (32%)
		TPR repeat	1805..1835	CDD:276809	6/18 (33%)
		TPR	1840..1873	CDD:197478
		TPR repeat	1840..1868	CDD:276809
		TPR_11	<1855..>1903	CDD:330823
		TPR repeat	1874..1902	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303136at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920