DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom70 and Tomm70a

DIOPT Version :9

Sequence 1:	NP_609536.1	Gene:	Tom70 / 34618	FlyBaseID:	FBgn0032397	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_613065.2	Gene:	Tomm70a / 28185	MGIID:	106295	Length:	611	Species:	Mus musculus

Alignment Length:	590	Identity:	232/590 - (39%)
Similarity:	351/590 - (59%)	Gaps:	45/590 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GSMKLTKWQLALILGTPLAIGLGTYAVKSWT-------------AASKELDGEKKRPKAKIEKQA 59
            |:..|.:|.:||.:|.||.:|.|  |:..|:             |:..:.:.|:|.|:.:.....
Mouse    35 GAGTLPRWHVALAIGAPLLLGAG--AMYLWSRRRRRREAGGRGDASGLKRNSERKTPEGRASPAL 97

  Fly    60 IS--LDGTAPDQELERNQKSAELGEKLSPLKEANNYKTEGNNCYRNGKYDEAIKFYDKAIDKCPK 122
            .|  .||:....|             :|.|..|...|.:||..::.|||::||:.|.:||..||.
Mouse    98 GSGHHDGSGDSLE-------------MSSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPT 149

  Fly   123 EHRTDMAIFYQNRAASYEMLKKWSNVKEDCTASLEFNPRYAKAYYRRARAHEATKDMNECLDDVT 187
            |...|::.|||||||::|.|:||..|.:|||.::|.||:|.||.:|||:|||...:..|||:|||
Mouse   150 EKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVT 214

  Fly   188 ATCILEMFQNNQTIMFADRVLKETGRLDAEKGMRNRVPVVPSACFVNTYTRSFIADPLQTMKVPA 252
            |.||||.|||.|:::.||:|||..|:.:|::..:||.|::||..|:.:|..||..|.:....:..
Mouse   215 AVCILEGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKG 279

  Fly   253 PKSDAPP------------KGFLRAHLAFLEEKYEEIIPACTEEIESSEAEAQYKVEALLMRGTF 305
            .|||...            .|:|:|.....||.|::||..|::||   :|:.:|..||||:|.||
Mouse   280 EKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEI---DAQGKYMAEALLLRATF 341

  Fly   306 HLLCGSYVESQQDFDAIIANDYADPNLRAYAYIKRAALYIQLDQREKGIADFAEAERLNPENPDV 370
            :||.||...::.|.|.:|:...|:..|||.|.|||..:.:|..|......||..|..::|.|.||
Mouse   342 YLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQPMLSTQDFNMAAEIDPMNSDV 406

  Fly   371 YHQRAQILLLLEQIEPALAEFEKAVSIAPNHAIAFVQKCYAEYRLSLLAGDQRRLESVMHTFQNA 435
            ||.|.|:.:||:.:|.|:|:|:..:.:.|..|:|..|||:|.||.:..|.:..::::.|..|:..
Mouse   407 YHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALYRQAYTANNSSQVQAAMKGFEEI 471

  Fly   436 IERFPSCVECYSLTAQVLADQQQFTQAEEYYKKAMVLAPTNPALIVHQAIMVLQWRGDINLAVQL 500
            |::||.|.|.|:|.||.|.|||||.:|:|.|.|.:.|.|.|....||:.::.|||:.|::..::|
Mouse   472 IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDKGLEL 536

  Fly   501 LNKAIEVDPKCELAYETLGTVEVQRAQLTRAVELFEKALLYAKSQAELVHVYSLRNAAVAQINVT 565
            ::||||:|.||:.||||:||:||||..:.:|:::|.||:..|||:.|:.|:|||.:||.||..|.
Mouse   537 ISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVA 601

  Fly   566 KKLGI 570
            ||.|:
Mouse   602 KKYGL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom70	NP_609536.1	TPR_11	89..160	CDD:290150	32/70 (46%)
		TPR repeat	90..118	CDD:276809	11/27 (41%)
		TPR repeat	123..158	CDD:276809	17/34 (50%)
		TPR repeat	296..324	CDD:276809	13/27 (48%)
		TPR_11	333..399	CDD:290150	25/65 (38%)
		TPR repeat	334..362	CDD:276809	10/27 (37%)
		TPR repeat	367..397	CDD:276809	13/29 (45%)
		TPR repeat	402..437	CDD:276809	11/34 (32%)
		TPR_16	413..477	CDD:290168	26/63 (41%)
		TPR repeat	443..471	CDD:276809	15/27 (56%)
		TPR repeat	476..507	CDD:276809	11/30 (37%)
		TPR_11	486..539	CDD:290150	25/52 (48%)
		TPR repeat	512..539	CDD:276809	13/26 (50%)
Tomm70a	NP_613065.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..110		7/40 (18%)
		PLN03088	<117..604	CDD:330826	208/489 (43%)
		TPR 1	117..150		14/32 (44%)
		TPR repeat	117..145	CDD:276809	11/27 (41%)
		TPR repeat	155..185	CDD:276809	15/29 (52%)
		TPR 2	156..189		18/32 (56%)
		TPR 3	297..330		12/35 (34%)
		TPR 4	332..365		14/32 (44%)
		TPR repeat	332..360	CDD:276809	13/27 (48%)
		TPR repeat	365..399	CDD:276809	12/33 (36%)
		TPR 5	370..403		11/32 (34%)
		TPR 6	404..437		13/32 (41%)
		TPR repeat	404..432	CDD:276809	12/27 (44%)
		TPR 7	445..478		10/32 (31%)
		TPR repeat	447..473	CDD:276809	6/25 (24%)
		TPR 8	479..512		17/32 (53%)
		TPR repeat	479..507	CDD:276809	15/27 (56%)
		TPR repeat	512..543	CDD:276809	11/30 (37%)
		TPR 9	514..547		12/32 (38%)
		TPR 10	548..581		16/32 (50%)
		TPR repeat	548..575	CDD:276809	13/26 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833733
Domainoid	1	1.000	182	1.000	Domainoid score	I3453
eggNOG	1	0.900	-	-		E1_KOG0547
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40112
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1666
Isobase	1	0.950	-	0	Normalized mean entropy	S2975
OMA	1	1.010	-	-		QHG59169
OrthoDB	1	1.010	-	-		D303136at2759
OrthoFinder	1	1.000	-	-		FOG0004725
OrthoInspector	1	1.000	-	-		oto95155
orthoMCL	1	0.900	-	-		OOG6_104251
Panther	1	1.100	-	-	LDO	PTHR46208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	1	1.000	-	-		X5061
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750