DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tom70 and TOMM34

DIOPT Version :9

Sequence 1:NP_609536.1 Gene:Tom70 / 34618 FlyBaseID:FBgn0032397 Length:589 Species:Drosophila melanogaster
Sequence 2:NP_006800.2 Gene:TOMM34 / 10953 HGNCID:15746 Length:309 Species:Homo sapiens


Alignment Length:346 Identity:85/346 - (24%)
Similarity:135/346 - (39%) Gaps:72/346 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 KTEGNNCYRNGKYDEAIKFYDKAIDKCPKEHRTD---MAIFYQNRAASYEMLKKWSNVKE---DC 152
            :..||..:|||:|.||...|.:|:.....:..:|   .::.|.||||.:   .|..|.::   ||
Human    13 RAAGNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACH---LKDGNCRDCIKDC 74

  Fly   153 TASLEFNPRYAKAYYRRARAHEATK-------DMNECLD-DVTATCILEMFQNNQTIMFADRVLK 209
            |::|...|...|...|||.|:||.:       |....|. |...|..:|.. |..|....|.:..
Human    75 TSALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGI-NRMTRALMDSLGP 138

  Fly   210 ETGRLDAEKGMRNRVPVVPSACFVNTYTR--SFIADPLQTM------KVPAPKSDAPPKGFLRAH 266
            | .||....     :|:||    |:...|  |..::..:.|      :..|.|:..|..|.:...
Human   139 E-WRLKLPS-----IPLVP----VSAQKRWNSLPSENHKEMAKSKSKETTATKNRVPSAGDVEKA 193

  Fly   267 LAFLEEKYEEIIPACTEEIESSEAEAQYKVEALLMRGTFHLLCGSYVESQQDFDAIIANDYADPN 331
            ....||..|                       |:.:|........|.||      ::.:     |
Human   194 RVLKEEGNE-----------------------LVKKGNHKKAIEKYSES------LLCS-----N 224

  Fly   332 LRAYAYIKRAALYIQLDQREKGIADFAEAERLNPENPDVYHQRAQILLLLEQIEPALAEFEKAVS 396
            |.:..|..||..|:.|.|..:.:.|..||.:|:.:|...:::|||....|:..:.:.|:....:.
Human   225 LESATYSNRALCYLVLKQYTEAVKDCTEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQ 289

  Fly   397 IAPNHAIAFVQKCYAEYRLSL 417
            |.|.:..|  ||...|.:.:|
Human   290 IEPRNGPA--QKLRQEVKQNL 308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tom70NP_609536.1 TPR_11 89..160 CDD:290150 22/71 (31%)
TPR repeat 90..118 CDD:276809 10/23 (43%)
TPR repeat 123..158 CDD:276809 12/40 (30%)
TPR repeat 296..324 CDD:276809 5/27 (19%)
TPR_11 333..399 CDD:290150 17/65 (26%)
TPR repeat 334..362 CDD:276809 9/27 (33%)
TPR repeat 367..397 CDD:276809 6/29 (21%)
TPR repeat 402..437 CDD:276809 5/16 (31%)
TPR_16 413..477 CDD:290168 1/5 (20%)
TPR repeat 443..471 CDD:276809
TPR repeat 476..507 CDD:276809
TPR_11 486..539 CDD:290150
TPR repeat 512..539 CDD:276809
TOMM34NP_006800.2 TPR 1 9..42 10/28 (36%)
TPR repeat 9..37 CDD:276809 10/23 (43%)
PLN03088 <12..>294 CDD:330826 80/328 (24%)
TPR repeat 50..80 CDD:276809 11/32 (34%)
TPR 2 51..84 12/35 (34%)
TPR repeat 85..113 CDD:276809 8/27 (30%)
TPR 3 86..118 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..189 4/27 (15%)
TPR 4 193..226 9/66 (14%)
TPR repeat 193..221 CDD:276809 8/56 (14%)
TPR repeat 226..256 CDD:276809 9/29 (31%)
TPR 5 227..260 10/32 (31%)
TPR repeat 261..289 CDD:276809 5/27 (19%)
TPR 6 262..294 7/31 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1535
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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