DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tom70 and tomm70

DIOPT Version :9

Sequence 1:	NP_609536.1	Gene:	Tom70 / 34618	FlyBaseID:	FBgn0032397	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001096527.1	Gene:	tomm70 / 100125169	XenbaseID:	XB-GENE-1007952	Length:	577	Species:	Xenopus tropicalis

Alignment Length:	584	Identity:	238/584 - (40%)
Similarity:	353/584 - (60%)	Gaps:	43/584 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GSMKLTKWQLALILGTPLAIGLGTYAVKSWTAASKELDGEKKRPKA-KIEKQAISLDGTAPDQEL 71
            |...:..|:|||.:|.||.:|.|  ||..|           :|.|| |.:||..:.:|.|.....
Frog    11 GGPGIPHWKLALAIGAPLLVGAG--AVYLW-----------RRHKAEKRDKQRRTPEGRASPVPA 62

  Fly    72 E----RNQKSAELGEKLSPLKEANNYKTEGNNCYRNGKYDEAIKFYDKAIDKCPKEHRTDMAIFY 132
            |    .|.:.|.  ::||||::|...|.:||..::..||::||:.|.:||..||.:.::|::.||
Frog    63 EGSSTNNPQDAP--QELSPLEKAQAAKNKGNKYFKASKYEQAIQCYTEAISLCPVDTKSDLSTFY 125

  Fly   133 QNRAASYEMLKKWSNVKEDCTASLEFNPRYAKAYYRRARAHEATKDMNECLDDVTATCILEMFQN 197
            |||||::|.|:.|..|.:|||.::|.||||.||.:|||:|||...:..|||:||||.||||.|||
Frog   126 QNRAAAHEQLQNWKEVVQDCTKAVELNPRYVKALFRRAKAHERLDNKKECLEDVTAVCILEGFQN 190

  Fly   198 NQTIMFADRVLKETGRLDAEKGMRNRVPVVPSACFVNTYTRSF----IADPLQTMKVPAPKSD-- 256
            .|::..||:|||..|:..|:...:||.|::||..|:.:|..||    |:.|||    ...|||
Frog   191 QQSMFLADKVLKLLGKEKAKDKYKNREPLMPSPQFIKSYFSSFTDDIISQPLQ----KGEKSDED 251

  Fly   257 ----------APPKGFLRAHLAFLEEKYEEIIPACTEEIESSEAEAQYKVEALLMRGTFHLLCGS 311
                      ....|:|:|.....||.|::||..||:|:||   ..:|..||||:|.||:||.|:
Frog   252 KDKEGEAAVVKEKSGYLKAKKYMEEENYDKIISECTKEVES---VGKYVAEALLLRATFYLLIGN 313

  Fly   312 YVESQQDFDAIIANDYADPNLRAYAYIKRAALYIQLDQREKGIADFAEAERLNPENPDVYHQRAQ 376
            ...::.|.|.:|:.:..:..|||.|.|||.::|:|.........||..|..::|:|.||||.|.|
Frog   314 AAAAKPDLDQVISMEECNVKLRANALIKRGSMYMQQQLPALSTQDFNMAADIDPQNADVYHHRGQ 378

  Fly   377 ILLLLEQIEPALAEFEKAVSIAPNHAIAFVQKCYAEYRLSLLAGDQRRLESVMHTFQNAIERFPS 441
            :.:||:|:|.|:.:|::.:.:.|:.|:|..|||:|.||.:....:..:::..|..|::.|.:||.
Frog   379 LKILLDQVEDAVEDFDECIRLRPDSALAQAQKCFALYRKAYTGSNPLQIKEAMQGFEDVITKFPK 443

  Fly   442 CVECYSLTAQVLADQQQFTQAEEYYKKAMVLAPTNPALIVHQAIMVLQWRGDINLAVQLLNKAIE 506
            |.|.|:|.||.|.|||||.:|:|.|.|.:.|.|.|....||:.::.|||:.|:...:.|::||||
Frog   444 CAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLEKGLDLISKAIE 508

  Fly   507 VDPKCELAYETLGTVEVQRAQLTRAVELFEKALLYAKSQAELVHVYSLRNAAVAQINVTKKLGI 570
            :|.||:.||||:||:||||..|.:|:|:|.||:..|||:.|:.|:|||.:||.||..|.:|.|:
Frog   509 IDNKCDFAYETMGTIEVQRGNLDKAIEMFNKAINLAKSEMEMAHLYSLCDAAYAQTEVARKYGL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom70	NP_609536.1	TPR_11	89..160	CDD:290150	29/70 (41%)
		TPR repeat	90..118	CDD:276809	10/27 (37%)
		TPR repeat	123..158	CDD:276809	15/34 (44%)
		TPR repeat	296..324	CDD:276809	12/27 (44%)
		TPR_11	333..399	CDD:290150	25/65 (38%)
		TPR repeat	334..362	CDD:276809	10/27 (37%)
		TPR repeat	367..397	CDD:276809	13/29 (45%)
		TPR repeat	402..437	CDD:276809	10/34 (29%)
		TPR_16	413..477	CDD:290168	25/63 (40%)
		TPR repeat	443..471	CDD:276809	15/27 (56%)
		TPR repeat	476..507	CDD:276809	11/30 (37%)
		TPR_11	486..539	CDD:290150	27/52 (52%)
		TPR repeat	512..539	CDD:276809	15/26 (58%)
tomm70	NP_001096527.1	3a0801s09	20..570	CDD:273380	234/571 (41%)
		TPR repeat	83..111	CDD:276809	10/27 (37%)
		TPR repeat	116..151	CDD:276809	15/34 (44%)
		TPR repeat	298..326	CDD:276809	12/27 (44%)
		TPR repeat	331..365	CDD:276809	12/33 (36%)
		TPR repeat	370..398	CDD:276809	12/27 (44%)
		TPR repeat	404..438	CDD:276809	10/33 (30%)
		TPR repeat	445..473	CDD:276809	15/27 (56%)
		TPR repeat	478..509	CDD:276809	11/30 (37%)
		TPR repeat	514..541	CDD:276809	15/26 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40112
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1661
OMA	1	1.010	-	-		QHG59169
OrthoDB	1	1.010	-	-		D303136at2759
OrthoFinder	1	1.000	-	-		FOG0004725
OrthoInspector	1	1.000	-	-		oto105340
Panther	1	1.100	-	-	LDO	PTHR46208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	1	1.000	-	-		X5061
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110