DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and NSMAF

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001138244.1	Gene:	NSMAF / 8439	HGNCID:	8017	Length:	948	Species:	Homo sapiens

Alignment Length:	895	Identity:	203/895 - (22%)
Similarity:	307/895 - (34%)	Gaps:	308/895 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 RKYNGAH----VRMCRS-TPSA--PSTKPPSGQGQLQPHDVV-----------LKELIQRVYRC- 169
            |.:.||.    :|.||| .|.|  |..:..||:|.......|           |:|.....:|.
Human     6 RFHRGAEACRAIRQCRSRRPRAAHPEGRAGSGRGSRHASPGVRRGGFSLLLLNLEEYYFEQHRAN 70

  Fly   170 PVLHCQLDRDGVSDSSNATSCSAGSCHANVLPALVAIETSTHISVFFYP-----PALECSLYDCI 229
            .:||                  .||.|...:...:.|.:.   ||.|.|     |.::..|.|||
Human    71 HILH------------------KGSHHERKIRGSLKICSK---SVIFEPDSISQPIIKIPLRDCI 114

  Fly   230 TFSPALLGKN--------------------YNKTLFV-IYQILQLAKHLQGQGLFLGDL----RL 269
            .     :||:                    :::..|: .:.::...|..:|:..::.:|    ::
Human   115 K-----IGKHGENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVPGKV 174

  Fly   270 QDIVLRENLWLQVLPRLQCNLLDDDPAGEDMSPLTPL-----------------VSEDLGEAREA 317
            :|:|  |.| || |.|..|.    |..|:..:.:|.:                 :||.|....:|
Human   175 EDVV--ETL-LQ-LHRASCL----DKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKA 231

  Fly   318 QQALPSSS---------------------------TMFDLRFAY--------------------- 334
            :...|..:                           |:.|:|..|
Human   232 EMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLC 296

  Fly   335 -------------DPAHFNLREYTE-------------MWCNGQLSNFDYLTILNNACGRSLTNA 373
                         |..:|.:..|.|             .|..|.|||:.||..|||...||..:.
Human   297 SDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDL 361

  Fly   374 AYHHIMPWVT-DFSG-----RGGGAWRDLTKSKYRLNKGDVHLDLMYAHASQHGSADGSYQAIGD 432
            :.:.:.||:. |:|.     ...|.:|||:|....|||  ..|:.:...          ||.:.:
Human   362 SQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNK--ERLERLLTR----------YQEMPE 414

  Fly   433 QAPHHVSDFLSEITYFVYMARRTPQSILCAH-------------VRPIWVPAEYPVSIQRLQEWT 484
            ....:.|.:.|......|:.|..|:.:||..             :...|         :...:..
Human   415 PKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETW---------KNCLDGA 470

  Fly   485 PD--ECIPEFYSDPMIF--KSIHEDL---------PDLELPAWATCPEDFICKHREALESQYVSE 536
            .|  |.|||||.|.:.|  .|:..||         .|:|||.||:.||||:.|.::||||.||||
Human   471 TDFKELIPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSE 535

  Fly   537 RLHHWIDLNFGYKLSGKAAVKSKNVCLTLVDQHRNLSQRGIVQLFASAHPPRRYA---------- 591
            .||.||||.||||..|..||.:.||       ...|:..|.|.|.:...|..:.|
Human   536 HLHEWIDLIFGYKQKGSDAVGAHNV-------FHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQ 593

  Fly   592 TPWFSRTAPRLSQLYASPAKRLAKSTENLQAESATGSSHLSLRLGDDGSSGSVHSSSASASASNF 656
            ||         .||:.:|..|  :.|...::.|.|.|.:.|  :.|.....|....:..:....:
Human   594 TP---------KQLFVTPHPR--RITPKFKSLSQTSSYNAS--MADSPGEESFEDLTEESKTLAW 645

  Fly   657 YAITNFIELPENYNPALLLHNLETLEAFYARTFPQQRASA-----NPEEKMISSDLMFEQNSAEH 716
            ..||. ::|.|:|.    :|.    ||....|..:..:|.     :...||.|.:....|.|.
Human   646 NNITK-LQLHEHYK----IHK----EAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSI-- 699

  Fly   717 SFTNQLFASGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIELFAMQRLRPLLMGNG- 780
            ||:|...:|...||..:..:.....|      ||            .....|..|.:..|||:.
Human   700 SFSNMALSSCLLLPGDATVITSSWDN------NV------------YFYSIAFGRRQDTLMGHDD 746

  Fly   781 ------------LTATFDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLE 818
                        .:|::||.:.....|.    .|:|...|....||.:||
Human   747 AVSKICWHDNRLYSASWDSTVKVWSGVP----AEMPGTKRHHFDLLAELE 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	87/287 (30%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
NSMAF	NP_001138244.1	PH-like	223..316	CDD:302622	10/92 (11%)
		Beach	335..606	CDD:280327	93/309 (30%)
		WD40	<645..947	CDD:225201	40/181 (22%)
		WD40	653..945	CDD:238121	38/172 (22%)
		WD40 repeat	664..701	CDD:293791	7/38 (18%)
		WD40 repeat	707..743	CDD:293791	9/53 (17%)
		WD40 repeat	748..782	CDD:293791	6/37 (16%)
		WD40 repeat	798..833	CDD:293791
		WD40 repeat	839..875	CDD:293791
		WD40 repeat	882..914	CDD:293791
		WD40 repeat	920..944	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820