DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and SPI

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_171805.1	Gene:	SPI / 839323	AraportID:	AT1G03060	Length:	3601	Species:	Arabidopsis thaliana

Alignment Length:	631	Identity:	149/631 - (23%)
Similarity:	217/631 - (34%)	Gaps:	222/631 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 ENLWLQVLPRLQCNLLDDDPAGEDMSPLTPLVSEDLGEAREAQQALPSSSTMFDLRFAYDPAHFN 340
            :||....|||  .::||...:|                  .|:|.......:|.|.
plant  2924 KNLVAMNLPR--NSMLDTTISG------------------SAKQESNEGGRLFKLM--------- 2959

  Fly   341 LREYTEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWV--------TDFSGRGGGAWRDLT 397
            .:.:::.|.||::|||.||..||...||..::...:.:.|||        .|||.         .
plant  2960 AKSFSKRWQNGEISNFQYLMHLNTLAGRGYSDLTQYPVFPWVLADYDSESLDFSD---------P 3015

  Fly   398 KSKYRLNKGDVHLDLMYAHASQHGSADGSYQAIGDQAPHHVSDFLS--------EITYFVYMARR 454
            |:..:|:|                       .:|.|.|....:|..        |:..|.|.:..
plant  3016 KTFRKLHK-----------------------PMGCQTPEGEEEFRKRYESWDDPEVPKFHYGSHY 3057

  Fly   455 TPQSILCAHVRPIWVPAEYPVSI--QRLQ----------------EW--------TPD--ECIPE 491
            :...|:..::  |.:|   |.|.  |:||                .|        |.|  |.|||
plant  3058 SSAGIVLFYL--IRLP---PFSSENQKLQGGQFDHADRLFNSIKDTWLSAAGKGNTSDVKELIPE 3117

  Fly   492 FYSDPMIF----------KSIHEDLPDLELPAWAT-CPEDFICKHREALESQYVSERLHHWIDLN 545
            |:..|...          |...|.:.|:.||.||. ...:||.||||||||.||||.|||||||.
plant  3118 FFYMPEFLENRFSLDLGEKQSGEKVGDVFLPPWARGSVREFILKHREALESDYVSENLHHWIDLI 3182

  Fly   546 FGYKLSGKAAVKSKNVC--------------------LTLVDQHRNLSQRGIVQLFASAHPPRRY 590
            ||||..||||.::.||.                    .:::.|..:..|.. .|||..||..|
plant  3183 FGYKQRGKAAEEAVNVFYHYTYEGNVDIDAVTDPAMKASILAQINHFGQTP-KQLFPKAHVKR-- 3244

  Fly   591 ATPWFSRTAPRLSQLYASPAKRLAKSTENLQAESATGSSHLSLRLGDDGSSGSVHSSSASASASN 655
                  ||..::      |...|..|...:..|....||.:|..:       :.|.....|.|:.
plant  3245 ------RTDRKI------PLHPLKHSMHLVPHEIRKCSSSISQII-------TFHDKVLVAGANC 3290

  Fly   656 FYAITNFIELPENYNPALLLHNLETLEAFYARTFPQQ--RASANPEEKMISS-DLMFEQNS---A 714
            |..       |..|.            .:....||.:  |..:..::|::|: :.:.|.|.   |
plant  3291 FLK-------PRGYT------------KYITWGFPDRSLRFMSYDQDKLLSTHENLHESNQIQCA 3336

  Fly   715 EHSFTNQLFASGDE------------LPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIELF 767
            ..|...::..:|.|            .|..|:.|..||..| .|...|.         ||.:.
plant  3337 GVSHDGRIVVTGAEDGLVCVWRVSKDGPRGSRRLRLEKALC-AHTAKVT---------CLRVS-- 3389

  Fly   768 AMQRLRPLLM---GNGLTATFDSRLSACRTVAQLHRQELPKPVRRV 810
                 :|.:|   |:.........||:...|.||  .:.|.|:..:
plant  3390 -----QPYMMIASGSDDCTVIIWDLSSLSFVRQL--PDFPVPISAI 3428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	90/317 (28%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
SPI	NP_171805.1	LamG	1120..>1224	CDD:304605
		PH_BEACH	2763..2929	CDD:275391	2/4 (50%)
		Beach	2965..3244	CDD:280327	90/316 (28%)
		WD40	<3304..3560	CDD:295369	31/144 (22%)
		WD40	<3307..3579	CDD:225201	29/141 (21%)
		WD40 repeat	3333..3378	CDD:293791	10/45 (22%)
		WD40 repeat	3384..3420	CDD:293791	10/53 (19%)
		WD40 repeat	3425..3461	CDD:293791	0/4 (0%)
		WD40 repeat	3545..3571	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820