DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and rg

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001284879.1	Gene:	rg / 44531	FlyBaseID:	FBgn0266098	Length:	3785	Species:	Drosophila melanogaster

Alignment Length:	687	Identity:	158/687 - (22%)
Similarity:	253/687 - (36%)	Gaps:	194/687 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 TPSAPSTKPPSGQ--GQLQPHDVVL---KELIQRVYRCPVLHCQLDRDG-VSDSSNATSCSAGSC 195
            |..|.|...||||  |:|.....:|   :||            .||..| |:.|:.|...:.|.
  Fly  2952 TQIAVSRTHPSGQHNGELLDDAELLIEDREL------------DLDLTGPVNISTKARLIAPGL- 3003

  Fly   196 HANVLPALVAIETSTHISVFFYPPALECSLYDCITFSPALLGKNYNKTLFVIYQILQLAKHLQGQ 260
               |.|..|:| |||  .:||.                  :.:.:.:...:..::|:...||.|:
  Fly  3004 ---VAPGTVSI-TST--EMFFE------------------VDEEHPEFQKIDGEVLKYCDHLHGK 3044

  Fly   261 GLFLGDLR--------LQDIVL------RENLW------------LQVLPRLQCNLLDDDPAGED 299
            ..| .::|        ||::.|      |.::.            ::.|||:...:....|....
  Fly  3045 WYF-SEVRAIFSRRYLLQNVALEIFLASRTSILFAFPDQHTVKKVIKALPRVGVGIKYGIPQTRR 3108

  Fly   300 MSPLTPLVSEDLGEAREAQQALPSSSTMFDLRFAYDPAHFNLREYTEMWCNGQLSNFDYLTILNN 364
            .|.::|             :.|..:|.|                 |:.|...::|||:||..||.
  Fly  3109 ASMMSP-------------RQLMRNSNM-----------------TQKWQRREISNFEYLMFLNT 3143

  Fly   365 ACGRSLTNAAYHHIMPWV-TDFSGRG-----GGAWRDLTKSKYRLNKGDVHLDLMYAHASQHGSA 423
            ..||:..:...:.|.||| |::..:.     ...:|||:|....||            .|:....
  Fly  3144 IAGRTYNDLNQYPIFPWVLTNYESKDLDLSLPSNYRDLSKPIGALN------------PSRRAYF 3196

  Fly   424 DGSYQAIGDQA--PHHVSDFLSEITYFV-YMARRTPQSILCAHVR------PIWVPAEYPVSIQR 479
            :..|::.....  |.|.....|...:.: ::.|..|.:.:...::      |..:.:...:|.:.
  Fly  3197 EERYESWDSDTIPPFHYGTHYSTAAFTLNWLVRVEPFTTMFLALQGGKFDYPDRLFSSVSLSWKN 3261

  Fly   480 LQEWTPD--ECIPEFYSDPMIFKSI-------HED---LPDLELPAWATCPEDFICKHREALESQ 532
            .|..|.|  |.|||:|..|.:|.:.       .||   :.|:|||.||..||:|:..:|.||||:
  Fly  3262 CQRDTSDVKELIPEWYFLPEMFYNSSGYRLGHREDGALVDDIELPPWAKSPEEFVRINRMALESE 3326

  Fly   533 YVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLV--------------------DQHRNLSQRGI 577
            :||.:||.||||.||||..|..|:::.||...|.                    :|.||..|..
  Fly  3327 FVSCQLHQWIDLIFGYKQRGPEAIRATNVFYYLTYEGSVDLDGVLDPVMREAVENQIRNFGQTP- 3390

  Fly   578 VQLFASAHPPRRYATPWFSRTAPRLSQLYASPAKRLAKSTENLQAESATGSSHLSLRLGDDGSSG 642
            .||....||||..|    ...:|.:.........::.|..:|......:.:::..|.|
  Fly  3391 SQLLMEPHPPRSSA----MHLSPMMFSAMPEDLCQMLKFYQNSPVIHISANTYPQLSL------- 3444

  Fly   643 SVHSSSASASASNFYAITNFIELPENYNPALLLHNLETLEAFYARTFPQQRASANPEEKMISSDL 707
               .|..:.:|.:.:|:..:     |.|     :........||.: ||...|..|        |
  Fly  3445 ---PSVVTVTAGHQFAVNRW-----NCN-----YTASVQSPSYAES-PQSPGSNQP--------L 3487

  Fly   708 MFEQNSAEHSFTNQL-FASGDELPPKSKNLLREKRNC 743
            ..:...|.|...|.. .||...|......:|:.:.||
  Fly  3488 TIDPVLAVHGTNNNSNAASRRHLGDNFSQMLKIRSNC 3524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	82/289 (28%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
rg	NP_001284879.1	LamG	210..358	CDD:304605
		DUF4704	634..918	CDD:292415
		MARCKS	1434..1751	CDD:280269
		DUF1088	2791..2972	CDD:284000	9/19 (47%)
		PH_BEACH	2996..3093	CDD:291510	21/122 (17%)
		Beach	3125..3401	CDD:280327	81/288 (28%)
		WD40 repeat	3524..3560	CDD:293791	1/1 (100%)
		WD40	<3526..3729	CDD:295369
		WD40	<3530..3773	CDD:225201
		WD40 repeat	3566..3617	CDD:293791
		WD40 repeat	3622..3657	CDD:293791
		WD40 repeat	3669..3699	CDD:293791
		WD40 repeat	3704..3739	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910