Protein Alignment Wdr81 and sorf-2

DIOPT Version :10

• Sequence 1: NP_609535.1
• Gene: Wdr81 / 34616
• FlyBaseID: FBgn0032395
• Length: 1953
• Species: Drosophila melanogaster
• Sequence 2: NP_001367877.1
• Gene: sorf-2 / 3565037
• WormBaseID: WBGene00018672
• Length: 1382
• Species: Caenorhabditis elegans
• Alignment Length: 1772
• Identity: 384/1772 - (21%)
• Similarity: 615/1772 - (34%)
• Gaps: 658/1772 - (37%)

  Fly   280 LQVLPRLQCNLLDDDPAGEDMSPLTPLVSEDLGEAREAQ------QALPSSSTMFDL------RF 332
            ||.:..|..||||             |.|:.......|:      :.|||....:|:      :|
 Worm   171 LQTIHFLTKNLLD-------------LYSQLFSRKITAEFKTRHFRCLPSFWLQYDVLAPIFEQF 222

  Fly   333 AYDPA-HFNLREYTEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVTDFSGRGGGAWRDL 396
            ....| ...|.|.|..|.|.:..|:.|||.||:..||.......|.|.|||.|||...|| :|.|
 Worm   223 RAPRAPRIPLDEATSNWANRKWENYQYLTYLNDITGRVRGEVHNHPIFPWVCDFSEENGG-FRQL 286

  Fly   397 TKSKYRLNKGDVHLDLMYAHASQHGSADGSYQAIGDQAPHHVSDFLSEITYFVYMARRTPQSILC 461
            .::||||.|||..|..||:.                :..|||.:.||:|.|.||.||..|:..||
 Worm   287 NRTKYRLCKGDDQLREMYSR----------------EPSHHVPELLSDIGYMVYRARVEPKDNLC 335

  Fly   462 AHVRPIWVPAEYPVSIQRLQEWTPDECIPEFYSDPMIFKSIHEDLPDLELPAWATCPEDFICKHR 526
            .|||..|||.|||.::.|:.:|||||||||||.||.||.|.|.|:.||..|.:.:.|::||..||
 Worm   336 RHVRRKWVPEEYPSTMSRMYQWTPDECIPEFYDDPSIFNSCHPDMADLRFPEFVSSPQEFIEWHR 400

  Fly   527 EALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVDQH-RNLSQRGIVQLFASAHPPRRY 590
            :.||.:.||..||.||||.||:.|:...:..:.|:.|..|::: |.|...|:||||...||
 Worm   401 KMLEHEEVSMNLHRWIDLVFGFNLAIDNSKNALNLHLCFVEKNRRGLRTTGMVQLFNRPHP---- 461

  Fly   591 ATPWFSRTAPRLSQLYASPAKRLAKSTENLQAESATGSSHLSLRLGDDGSSGSVHSSSASASASN 655
                                                                             
 Worm   462 ----------------------------------------------------------------- 461

  Fly   656 FYAITNFIELPENYNPALLLHNLETLEAF-YARTFPQQRASANPEEKMISSDLMFEQNSAEHSFT 719
                   |.:|.||:|.|..::|: :|:| :..|...::   .||         .|.:...|
 Worm   462 -------IRMPLNYDPKLDNYHLK-MESFGFGMTSEHRK---EPE---------VEPDEDSH--- 503

  Fly   720 NQLFASGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIELFAMQRLRPLLMGNGLTAT 784
            .|::                     |.:..||:.|.......::   .||:.:..:::...|...
 Worm   504 YQIY---------------------QKIKKVRRLRHNTYFSSMV---SAMEVMAQIVLAPHLAGR 544

  Fly   785 FDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLEQ--PGEEDQGLPQPPNPAQLLEPMFSNLLLP 847
            ||.. ...|...||:...:|...||:...|...||  |..::..             .|.::.|.
 Worm   545 FDDP-DHIRRCIQLYSYRIPANYRRLFDFLFNTEQDFPDCDEFS-------------FFVSVRLN 595

  Fly   848 FPS---HYMAVYALVRSLHAFEANAVLLELQTHFSCKGGRECERYTEMDRQRVLFERKIAEC-KV 908
            .|:   ::...:....|||....    |::...||             .|.:::..:::... |.
 Worm   596 IPTKILNFSEEFGKCVSLHILRK----LDVIPPFS-------------KRSQLIILKEVESLKKS 643

  Fly   909 MSCCAHVKRLLEPMSFAYEQFTPVELLLPHIIDLLRDERTSILTAWNLFDPIAQALGVSQTQQHL 973
            :..|.|:::.:..   |::|             ||.||...|.:...|...|.::|..|..:. |
 Worm   644 IRLCDHMEQCVVA---AFQQ-------------LLEDEEACIQSVHRLMPVITRSLSQSALED-L 691

  Fly   974 LQPLLKLYDVESVSSPDDGGSNGSTNSGGHLRFSASSSFKSRKSVKLYHHSFLLRLIVRFGLRCF 1038
            :.|:::|...|:                               ||||....||:.:.:.:|...|
 Worm   692 INPMIELIQCET-------------------------------SVKLLDRRFLMHVSICYGTHTF 725

  Fly  1039 LHHFIAPLIEAVGGYKEPEQGNGYHYHSGGSRRTSKNLNFASENEVHQTEVAPEMKPDIEELFTF 1103
            |..|:.|::||
 Worm   726 LDLFLPPIVEA------------------------------------------------------ 736

  Fly  1104 EDDHDRASTQDSKSIDSFDMRPSTSAASAEEARESDGSPDKLVINELIYGARISPDKLSLKESQT 1168
                                                                             
 Worm   737 ----------------------------------------------------------------- 736

  Fly  1169 PPALVPPPIGPRSPTIEIPMGPTAGGIRRSFQLSAIDCDIGSRKSVDSFDLISQAVEQLPPPAEE 1233
                                            .::::||
 Worm   737 --------------------------------CASMNCD-------------------------- 743

  Fly  1234 SEAEASDSLQASVISRLSEAKAVQNNRISEMSAESLVWLSHRLGPVLTSRFITRNLLKLLSLCYV 1298
                      .||:::                 ||::||:.|.|||:.::||:.|:|::::.||.
 Worm   744 ----------RSVVAK-----------------ESIMWLAKRYGPVICAKFISSNVLRIMASCYE 781

  Fly  1299 GQENLLPEVDDGGSSFNSSPDAANLNYFSIANARVVGDRSAARVLECLMSIAALYGENFLLLQYF 1363
            ..|.:         .....|.|       :.|..:.||.:.:|:...|..|...|...|:.:|:.
 Worm   782 AFEMV---------GLEQQPKA-------VFNVVLQGDETCSRIESLLSEIVLTYSVTFITVQFL 830

  Fly  1364 PHISELISLCSKRITGSLEGAIISSLQLLKYMVPCLTDASIMEHLQHIMLDAILLPILRLLSSTN 1428
            |...:||....||.:..||..::|..::::..:..::|..:|.:|:..::..::..:|.:|...:
 Worm   831 PFCVDLIEQFHKRSSVQLEPGLVSVFRIVELSIRSMSDHQLMNYLEEFIIQKVIYRVLTILLDAS 895

  Fly  1429 LVMPSGYLGRSLLARKFLDAIYALSVRLGSDMTREHLCQPL------------------LN---- 1471
            ....|..: |.::..|....:::::.::|::.||.:..||.                  :|
 Worm   896 FQFSSMRV-RIIIICKVCQLLHSITQKIGTENTRIYANQPFKLMFSTFSEIYETDEELRINLRKR 959

  Fly  1472 ---------PFFLI------FNKAFGLP--NDFACDLANL----SLVGGASQPERALEELRDVFG 1515
                     |.:::      |.|.:|:|  :.|..|.|.|    |....:|.|..::     ...
 Worm   960 PSENTLFEVPLWMVEDVVDKFAKEWGVPFLSSFCDDPAFLIPFVSNSSSSSSPPASI-----AHS 1019

  Fly  1516 PELAHTAYLTFLRFLGEANMKRTLSNLDFVLTLCHEHEQPNGQSKIQLATNVSSGQDVDSVDASC 1580
            |..|.|||     .||                                  .:|||..:.|:.||.
 Worm  1020 PPSAFTAY-----SLG----------------------------------GMSSGNRLFSLSASS 1045

  Fly  1581 EL-AANSFGTQIVGNRLQVARNNVELIDMVAYKLDQMPKTRHLKGNWLAYWRNETTRNEKDTQTL 1644
            .: :.||.|             .:...|               .|:..|.|....:.........
 Worm  1046 PVNSVNSLG-------------GLSFCD---------------SGSLSAVWCARVSAAVCGVDNY 1082

  Fly  1645 NLKQIRLQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLRSEGDGRKTSACQFTYTAHKKS 1709
            ....:.|.::.||...:|.:.|:.|||||:|||.||||||||::.|.|   ...||:||..|.:.
 Worm  1083 RFDHLSLCNYTGHQEKIRKLAAISNENSFVSASSDKTVKLWSIKPELD---EIGCQWTYQKHTRP 1144

  Fly  1710 INSLGFLESLRYVVSCDSGIHLWDPFI----------------GRPLSVLDAPRH--SAVTVVKC 1756
            ::.:..|.. ..:.|.|..:|:||||.                |..:.|.:..||  ||:    |
 Worm  1145 VHDITILAD-NSIASTDGVLHVWDPFRTTLLAQMEWDSKEGSGGNIMRVENVDRHILSAI----C 1204

  Fly  1757 LPSHSPLVIAGTAESTVKMVDARSCEYVNEWRVCNASL---PNATVRCLAVAPSGNWLAAGLSSG 1818
                       :..||||:.|:|    |..| .|...:   |..| |.:.|...||.:|..||:|
 Worm  1205 -----------SLHSTVKLFDSR----VGGW-TCELKVSPGPGLT-RAITVRDKGNKMAVALSNG 1252

  Fly  1819 CIVQLDTRTGMV-----INSWRPMECDLLQ----LAAPSDQ---FLVSSALDHSLAVWHALDGIM 1871
            .:..||.|.|.:     .||...:..:.|.    |...:|:   ||.::...|.:.
 Worm  1253 TLAILDARNGKINALAQTNSTHTVSVNWLSDTRLLVCDADECGIFLETNPRAHIVR--------- 1308

  Fly  1872 HYQLKPPPEPAHFLQSVGPSLVYATTGNRVGVYADVAHSHAFSTITKLRSETFRGVLTSLAVLPL 1936
              :|:.|...|....:   |||....|..:.||   .:|......||:|.:...|..|::..|||
 Worm  1309 --KLQDPVSAACLTDN---SLVTLQNGTILRVY---RNSGELQIETKIRPDELPGTPTAVLPLPL 1365

  Fly  1937 NRAFLAGNESGNIALLC 1953
            |.::|.|:..|.|.|:|
 Worm  1366 NCSYLIGSSHGAIRLMC 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	108/243 (44%)
		WD40	1651..1876	CDD:475233	74/257 (29%)
		WD40 repeat	1662..1705	CDD:293791	24/42 (57%)
		WD40 repeat	1710..1744	CDD:293791	10/49 (20%)
		WD40 repeat	1752..1788	CDD:293791	8/35 (23%)
		WD40 repeat	1799..1836	CDD:293791	14/41 (34%)
sorf-2	NP_001367877.1	Beach	236..463	CDD:214982	108/319 (34%)
		WD40	1062..1292	CDD:475233	73/254 (29%)
		WD40 repeat	1099..1139	CDD:293791	23/42 (55%)
		WD40 repeat	1163..1226	CDD:293791	21/82 (26%)
		WD40 repeat	1233..1269	CDD:293791	13/36 (36%)