DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and Nsmaf

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_852054.2	Gene:	Nsmaf / 353233	RGDID:	727868	Length:	920	Species:	Rattus norvegicus

Alignment Length:	995	Identity:	217/995 - (21%)
Similarity:	330/995 - (33%)	Gaps:	358/995 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 SVFFYP-----PALECSLYDC------------------------ITFSPALLGKNYNKTLFVIY 248
            ||.|.|     |.|:..|.||                        :.||.....|.:|  :...|
  Rat    62 SVIFEPDAISQPILKIPLRDCLKIGKHGENGANKHFAKAKSLGISLIFSQVYFIKEHN--IVAPY 124

  Fly   249 QI----LQLAKHLQGQGLFLGDLRLQDIVLRENLWLQVLPRLQCNLLDDDPAGEDMSPLTPL--- 306
            :|    ::....|:..|      :::|:|  |.| || |.|..|.    |..|:.|:.:|.:
  Rat   125 KIERGKMEYVFQLEVSG------KVEDVV--ETL-LQ-LHRASCL----DKLGDQMAMITAILQS 175

  Fly   307 --------------VSEDLGEAREAQQALPSSS---------------------------TMFDL 330
                          |||.|....:|:...|..:                           |:.|:
  Rat   176 RLARTSFDKNRFQSVSEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDV 240

  Fly   331 RFAY----------------------------------DPAHFNLREYTE-------------MW 348
            |..|                                  |..:|.:..|.|             .|
  Rat   241 RRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQW 305

  Fly   349 CNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWV-TDFSG-----RGGGAWRDLTKSKYRLNKGD 407
            ..|.|||:.||..|||...||..:.:.:.:.||| :|:|.     .....:|||:|....||  .
  Rat   306 QRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWVISDYSSPELDLSNPATFRDLSKPVGALN--P 368

  Fly   408 VHLDLMYAHASQHGSADGSYQAIGDQAPHHVSDFLSEITYFVYMARRTPQSILCAH--------- 463
            ..|:.:...          ||.:.:....:.|.:.|......|:.|..|:.:||..
  Rat   369 ERLERLLTR----------YQEMPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADR 423

  Fly   464 ----VRPIWVPAEYPVSIQRLQEWTPD--ECIPEFYSDPMIF--KSIHEDL---------PDLEL 511
                :...|         :...:...|  |.|||||.:...|  .|:..||         .|:||
  Rat   424 MFNSIAETW---------KNCLDGATDFKELIPEFYDEDASFLINSLKLDLGKRQGGQMVDDVEL 479

  Fly   512 PAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLV---------- 566
            ||||:.|:||:.|:::||||.||||.||.||||.||||..|..|:.:.||...|.
  Rat   480 PAWASSPQDFLQKNKDALESSYVSEHLHEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSI 544

  Fly   567 ----DQHRNLSQ-----RGIVQLFASAHPPRRYATPWF---SRTAPRLSQLYASPAKRLAKSTEN 619
                |:...|:|     :...|||.:.||  |..||.|   |:.:...:.:..||.....:|.|:
  Rat   545 EDPDDKVAMLTQILEFGQTPKQLFVTPHP--RRITPKFKSLSQASSYNASMTDSPVSPGEESFED 607

  Fly   620 LQAESAT--GSSHLSLRLGDDGSSGSVHSSSASASASNFYAITNFIELPENYNPALLLHNLETLE 682
            |..||.|  .::...|:|.:   ...:|..:.:..|.:....:.|....::           ||:
  Rat   608 LTEESKTLAWNNITKLQLHE---QYKIHKEAVTGIAVSCNGSSVFTTSQDS-----------TLK 658

  Fly   683 AFYARTFPQQRASANPEEKMISSDLMFEQNSAEHSFTNQLFASGDELPPKSKNLLREKRNCLQHL 747
            .|            :.|.||:...:         ||:|...:|...||..:..:.....|
  Rat   659 MF------------SKESKMLQRSI---------SFSNMALSSCLLLPGDTTVISSSWDN----- 697

  Fly   748 LNVRKERDLHVLGCLIIELFAMQRLRPLLMGNG-------------LTATFDSRLSACRTVAQLH 799
             ||            .....|..|.:..|||:.             .:|::||.:.....|.
  Rat   698 -NV------------YFYSIAFGRRQDTLMGHDDAVSKICWHNDRLYSASWDSTVKVWSGVP--- 746

  Fly   800 RQELPKPVRRVVRLLLQLEQPGEEDQGLPQPPNPAQLLEPMFSNLLLPFPSHYMAVYALVRSLHA 864
             .|:|...|....||.:||                                |.::|..:  :|:|
  Rat   747 -AEMPGTKRHQFDLLAELE--------------------------------HDVSVNTI--NLNA 776

  Fly   865 FEANAV---------LLELQT-----HFSCKGGRECERYTEMDRQRVLFERKIAECKVMSCCAHV 915
            .....|         :.:|.|     ..||..|..|:.....|.:.||       ...:..|.:|
  Rat   777 VSTLLVSGTKEGLVNIWDLTTATLLHQISCHSGTVCDAAFSPDSRHVL-------STGVDGCLNV 834

  Fly   916 KRLLEPM---SFAYEQFTPVELLLPHIIDLLRDERTSILTAWNLFDPIAQALG--VSQTQQHLLQ 975
            ..:...|   |.|.|:  |....:.....:|...||..|..|:|       ||  ||:..|....
  Rat   835 IDVQTGMLISSMASEE--PQRCFVWDGNSVLSGSRTGELLVWDL-------LGAKVSERIQGHTG 890

  Fly   976 PLLKLYDVESVSSPDDGGSN 995
            .:..::..|..||...||.:
  Rat   891 AVTCIWMNEQCSSIITGGED 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	88/306 (29%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
Nsmaf	NP_852054.2	PH-like	192..285	CDD:418428	10/92 (11%)
		Beach	304..575	CDD:396627	87/293 (30%)
		WD40	625..917	CDD:238121	72/393 (18%)
		WD40 repeat	636..673	CDD:293791	8/68 (12%)
		WD40 repeat	679..715	CDD:293791	9/53 (17%)
		WD40 repeat	720..764	CDD:293791	9/47 (19%)
		WD40 repeat	770..805	CDD:293791	5/36 (14%)
		WD40 repeat	811..848	CDD:293791	8/43 (19%)
		WD40 repeat	892..916	CDD:293791	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910