DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and Nsmaf

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_006537725.1	Gene:	Nsmaf / 18201	MGIID:	1341864	Length:	956	Species:	Mus musculus

Alignment Length:	949	Identity:	198/949 - (20%)
Similarity:	311/949 - (32%)	Gaps:	356/949 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 GVSDSSNATSCSAGSCHANVLPALVAIETSTHI--------------------SVFFYP-----P 219
            |.|::..|..|.......|:........|:.|:                    ||.|.|     |
Mouse    38 GSSEAGYARKCRFSLLLLNLEEYYFEQHTAFHVQHQGSQEERKIRGSLKICSKSVIFEPDAISQP 102

  Fly   220 ALECSLYDCITFSPALLGKN----YNKTL---------FVIYQILQLAKH--------LQGQGLF 263
            .|:..|.||:.     :||:    .||..         .:..||..:.:|        .:|:..:
Mouse   103 ILKIPLRDCLK-----IGKHGENGANKHFAKAKSWGISLIFSQIYFIKEHNIVAPYKIERGKMEY 162

  Fly   264 LGDL----RLQDIVLRENLWLQVLPRLQCNLLDDDPAGEDMSPLTPL-----------------V 307
            :.:|    :::|:|  |.| || |.|..|.    |..|:.|:.:|.:                 |
Mouse   163 VFELEVSGKVEDVV--ETL-LQ-LHRASCL----DKLGDQMAMITAILQSRLARTSFDKNRFQSV 219

  Fly   308 SEDLGEAREAQQALPSSS---------------------------TMFDLRFAY----------- 334
            ||.|....:|:...|..:                           |:.|:|..|
Mouse   220 SEKLHMECKAEMVTPLVTNPGHVCITDTSLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGL 284

  Fly   335 -----------------------DPAHFNLREYTE-------------MWCNGQLSNFDYLTILN 363
                                   |..:|.:..|.|             .|..|.|||:.||..||
Mouse   285 EVFCTDDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHAAEHTAESYMLQWQRGHLSNYQYLLHLN 349

  Fly   364 NACGRSLTNAAYHHIMPW-VTDFSG-----RGGGAWRDLTKSKYRLNKGDVHLDLMYAHASQHGS 422
            |...||..:.:.:.:.|| ::|:|.     .....:|||:|....||.  ..|:.:...
Mouse   350 NLADRSCNDLSQYPVFPWIISDYSSPELDLSNPATFRDLSKPVGALNA--ERLERLLTR------ 406

  Fly   423 ADGSYQAIGDQAPHHVSDFLSEITYFVYMARRTPQSILCAH-------------VRPIWVPAEYP 474
                ||.:.:....:.|.:.|......|:.|..|:.:||..             :...|
Mouse   407 ----YQEMPEPRFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETW------ 461

  Fly   475 VSIQRLQEWTPD--ECIPEFYSDPMIF--KSIHEDL---------PDLELPAWATCPEDFICKHR 526
               :...:...|  |.|||||.:.:.|  .|:..||         .|::|||||:.|:||:.|::
Mouse   462 ---KNCLDGATDFKELIPEFYDEDVSFLVNSLKLDLGKRQGGQMVDDVDLPAWASSPQDFLQKNK 523

  Fly   527 EALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVC--------------------LTLVDQHRN 571
            :||||.||||.||.||||.||||..|..|:.:.||.                    :.::.|...
Mouse   524 DALESGYVSEHLHEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDEKVAMLTQILE 588

  Fly   572 LSQRGIVQLFASAHPPRRYATPWF---SRTAPRLSQLYASPAKRLAKSTENLQAESAT--GSSHL 631
            ..|.. .|||.:.||  |..||.|   |:.:...:.|..||.....:|.|:|..||.|  .|:..
Mouse   589 FGQTP-KQLFVTPHP--RRITPKFKSLSQASSYNASLTDSPVSPGEESFEDLTEESRTLAWSNIA 650

  Fly   632 SLRLGDDGSSGSVHSSSASASASNFYAITNFIELPENYNPALLLHNLETLEAFYARTFPQQRASA 696
            .|:|.:   ...:|..:.:..|.:....:.|....::           ||:.|
Mouse   651 KLQLHE---QYKIHKEAVTGIAVSCNGSSVFTTSQDS-----------TLKMF------------ 689

  Fly   697 NPEEKMISSDLMFEQNSAEHSFTNQLFASGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGC 761
            :.|.||:...:         ||:|...:|...||..:..:.....|      ||
Mouse   690 SKESKMLQRSI---------SFSNMALSSCLLLPGDTTVISSSWDN------NV----------- 728

  Fly   762 LIIELFAMQRLRPLLMGNG-------------LTATFDSRLSACRTVAQLHRQELPKPVRRVVRL 813
             .....|..|.:..|||:.             .:.::||.:.....|.    .|:|...|....|
Mouse   729 -YFYSIAFGRRQDTLMGHDDAVSKICWHNDRLYSGSWDSTVKVWSGVP----AEMPGTKRHQFDL 788

  Fly   814 LLQLEQPGEEDQGLPQPPNPAQLLEPMFSNLLLPFPSHYMAVYALVRSLHAFEANAV-------- 870
            |.:||                                |.:::..|:..::....|||
Mouse   789 LAELE--------------------------------HDVSMTYLLEKVNTINLNAVSTLLVSGT 821

  Fly   871 ------LLELQT-----HFSCKGGRECERYTEMDRQRVL 898
                  :.:|.|     ..||..|..|:.....|.:.:|
Mouse   822 KEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHIL 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	84/307 (27%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
Nsmaf	XP_006537725.1	PH_BEACH	221..314	CDD:275391	10/92 (11%)
		Beach	333..604	CDD:366934	83/294 (28%)
		WD40	654..953	CDD:238121	47/296 (16%)
		WD40 repeat	665..702	CDD:293791	8/68 (12%)
		WD40 repeat	708..744	CDD:293791	9/53 (17%)
		WD40 repeat	749..793	CDD:293791	8/47 (17%)
		WD40 repeat	806..841	CDD:293791	5/34 (15%)
		WD40 repeat	847..884	CDD:293791	3/14 (21%)
		WD40 repeat	928..952	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910